Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation

The anterior cruciate ligament (ACL) is the major intraarticular ligamentous structure of the knee, which functions as a joint stabilizer. It is the most commonly injured ligament of the knee, with over 150,000 ACL surgeries performed annually in the United States. Due to limitations associated with...

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Veröffentlicht in:	Biomaterials 2005-05, Vol.26 (13), p.1523-1532
Hauptverfasser:	Cooper, James A., Lu, Helen H., Ko, Frank K., Freeman, Joseph W., Laurencin, Cato T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Animals Anterior cruciate ligament Anterior Cruciate Ligament - cytology Anterior Cruciate Ligament - growth & development Anterior Cruciate Ligament - surgery Biocompatible Materials - chemistry Bioprosthesis Cell Adhesion - physiology Cell Culture Techniques - methods Cell Movement - physiology Cell Proliferation Cells, Cultured Degradable Elasticity Fibroblasts - cytology Fibroblasts - physiology Lactic Acid - chemistry Ligament and ligament tissue engineering Ligament repair Materials Testing Mice Mice, Inbred BALB C Polyglycolic Acid - chemistry Polymer Polymers - chemistry Porosity Rabbits Surface Properties Tensile Strength Tissue engineering Tissue Engineering - methods
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