KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors
Killer immunoglobulin‐like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidenti...
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| Veröffentlicht in: | Pediatric Blood & Cancer 2009-07, Vol.53 (1), p.120-124 |
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| creator | Pérez-Martínez, Antonio Leung, Wing Muñoz, Evangelina Iyengar, Rekha Ramírez, Manuel Vicario, José Luis Lassaletta, Álvaro Sevilla, Julián González-Vicent, Marta Madero, Luis Díaz-Pérez, Miguel Ángel |
| description | Killer immunoglobulin‐like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR–HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity. Pediatr Blood Cancer 2009;53:120–124. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/pbc.21955 |
| format | Article |
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Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR–HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity. 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Blood Cancer</addtitle><description>Killer immunoglobulin‐like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR–HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity. Pediatr Blood Cancer 2009;53:120–124. © 2009 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>Bone Neoplasms - genetics</subject><subject>Bone Neoplasms - immunology</subject><subject>Bone Neoplasms - secondary</subject><subject>Bone Neoplasms - therapy</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Graft Rejection - immunology</subject><subject>haploidentical stem cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>HLA-B Antigens - genetics</subject><subject>HLA-C Antigens - genetics</subject><subject>Humans</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - transplantation</subject><subject>KIR-HLA mismatch</subject><subject>Lung Neoplasms - immunology</subject><subject>Lung Neoplasms - secondary</subject><subject>Male</subject><subject>Neuroblastoma - genetics</subject><subject>Neuroblastoma - immunology</subject><subject>Neuroblastoma - secondary</subject><subject>Neuroblastoma - therapy</subject><subject>NK cells</subject><subject>pediatric solid tumors</subject><subject>Receptors, KIR - genetics</subject><subject>Remission Induction</subject><subject>Rhabdomyosarcoma - genetics</subject><subject>Rhabdomyosarcoma - immunology</subject><subject>Rhabdomyosarcoma - secondary</subject><subject>Rhabdomyosarcoma - therapy</subject><subject>Sarcoma, Ewing - genetics</subject><subject>Sarcoma, Ewing - immunology</subject><subject>Sarcoma, Ewing - therapy</subject><subject>Testicular Neoplasms - genetics</subject><subject>Testicular Neoplasms - immunology</subject><subject>Testicular Neoplasms - therapy</subject><issn>1545-5009</issn><issn>1545-5017</issn><issn>1096-911X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhi0EoqWw4AWQV0gs3NpObE-WZQQzhRGXCtSl5TjHrSGJU9uh9GV4VjydoawQq-PLdz6dox-h54weM0r5ydTaY84aIR6gQyZqQQRl6uH9mTYH6ElK3woqqVg8Rges4ay880P06_3ZOVlvTnEEC1MOkfT-0owdHnwaTLZX2KQUrDcZOnzjc7njy2hcJj8gpjmRPA8hYnAObMZ-xFdm6oPvYMzemh6nDAO20Pc4RzOmqTdjNtmHEbvSNkFXzNFbPEA2aftjcQq97_CdNz1Fj5zpEzzb1yP09e2bL8s12XxcnS1PN8RWDRekXTinlBI1U7wqs1jOHau7quVWtpI2C2g5SAHKtlw24GgpgrWyUVyBqWh1hF7uvFMM1zOkrMv-27HNCGFOWipeN7Su_gtySuWC17KAr3agjSGlCE5P0Q8m3mpG9TY1XVLTd6kV9sVeOrcDdH_JfUwFONkBN76H23-b9KfXyz9KsuvwJYGf9x0mfi-7VEroiw8rrS7ena_Wn5VeV78BrpizqQ</recordid><startdate>20090715</startdate><enddate>20090715</enddate><creator>Pérez-Martínez, Antonio</creator><creator>Leung, Wing</creator><creator>Muñoz, Evangelina</creator><creator>Iyengar, Rekha</creator><creator>Ramírez, Manuel</creator><creator>Vicario, José Luis</creator><creator>Lassaletta, Álvaro</creator><creator>Sevilla, Julián</creator><creator>González-Vicent, Marta</creator><creator>Madero, Luis</creator><creator>Díaz-Pérez, Miguel Ángel</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20090715</creationdate><title>KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors</title><author>Pérez-Martínez, Antonio ; Leung, Wing ; Muñoz, Evangelina ; Iyengar, Rekha ; Ramírez, Manuel ; Vicario, José Luis ; Lassaletta, Álvaro ; Sevilla, Julián ; González-Vicent, Marta ; Madero, Luis ; Díaz-Pérez, Miguel Ángel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3925-b8ff777541723effc22f14d3b2c6b6098eb2e65e7cb269ef0b2651b69727ea303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Bone Neoplasms - genetics</topic><topic>Bone Neoplasms - immunology</topic><topic>Bone Neoplasms - secondary</topic><topic>Bone Neoplasms - therapy</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Fatal Outcome</topic><topic>Female</topic><topic>Graft Rejection - immunology</topic><topic>haploidentical stem cell transplantation</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>HLA-B Antigens - genetics</topic><topic>HLA-C Antigens - genetics</topic><topic>Humans</topic><topic>Killer Cells, Natural - immunology</topic><topic>Killer Cells, Natural - transplantation</topic><topic>KIR-HLA mismatch</topic><topic>Lung Neoplasms - immunology</topic><topic>Lung Neoplasms - secondary</topic><topic>Male</topic><topic>Neuroblastoma - genetics</topic><topic>Neuroblastoma - immunology</topic><topic>Neuroblastoma - secondary</topic><topic>Neuroblastoma - therapy</topic><topic>NK cells</topic><topic>pediatric solid tumors</topic><topic>Receptors, KIR - genetics</topic><topic>Remission Induction</topic><topic>Rhabdomyosarcoma - genetics</topic><topic>Rhabdomyosarcoma - immunology</topic><topic>Rhabdomyosarcoma - secondary</topic><topic>Rhabdomyosarcoma - therapy</topic><topic>Sarcoma, Ewing - genetics</topic><topic>Sarcoma, Ewing - immunology</topic><topic>Sarcoma, Ewing - therapy</topic><topic>Testicular Neoplasms - genetics</topic><topic>Testicular Neoplasms - immunology</topic><topic>Testicular Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pérez-Martínez, Antonio</creatorcontrib><creatorcontrib>Leung, Wing</creatorcontrib><creatorcontrib>Muñoz, Evangelina</creatorcontrib><creatorcontrib>Iyengar, Rekha</creatorcontrib><creatorcontrib>Ramírez, Manuel</creatorcontrib><creatorcontrib>Vicario, José Luis</creatorcontrib><creatorcontrib>Lassaletta, Álvaro</creatorcontrib><creatorcontrib>Sevilla, Julián</creatorcontrib><creatorcontrib>González-Vicent, Marta</creatorcontrib><creatorcontrib>Madero, Luis</creatorcontrib><creatorcontrib>Díaz-Pérez, Miguel Ángel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric Blood & Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pérez-Martínez, Antonio</au><au>Leung, Wing</au><au>Muñoz, Evangelina</au><au>Iyengar, Rekha</au><au>Ramírez, Manuel</au><au>Vicario, José Luis</au><au>Lassaletta, Álvaro</au><au>Sevilla, Julián</au><au>González-Vicent, Marta</au><au>Madero, Luis</au><au>Díaz-Pérez, Miguel Ángel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors</atitle><jtitle>Pediatric Blood & Cancer</jtitle><addtitle>Pediatr. Blood Cancer</addtitle><date>2009-07-15</date><risdate>2009</risdate><volume>53</volume><issue>1</issue><spage>120</spage><epage>124</epage><pages>120-124</pages><issn>1545-5009</issn><eissn>1545-5017</eissn><eissn>1096-911X</eissn><abstract>Killer immunoglobulin‐like receptors (KIRs) on natural killer cells (NKs) recognize groups of human leukocyte antigen (HLA) class I alleles. Cells without an inhibitory HLA ligand may trigger NK activation. Reduced risk of relapse has been reported in malignant hematologic diseases after haploidentical transplantation when HLA ligands against the inhibitory KIRs present in the donor were absent in the recipient. We performed haploidentical transplant in three children with refractory solid tumors. Our results showed that beneficial antitumor effects could be observed in the presence of inhibitory KIR–HLA mismatch. These preliminary results suggest a possible association between disease control and NK cell alloreactivity. Pediatr Blood Cancer 2009;53:120–124. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19215002</pmid><doi>10.1002/pbc.21955</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Bone Neoplasms - genetics Bone Neoplasms - immunology Bone Neoplasms - secondary Bone Neoplasms - therapy Child, Preschool Combined Modality Therapy Fatal Outcome Female Graft Rejection - immunology haploidentical stem cell transplantation Hematopoietic Stem Cell Transplantation HLA-B Antigens - genetics HLA-C Antigens - genetics Humans Killer Cells, Natural - immunology Killer Cells, Natural - transplantation KIR-HLA mismatch Lung Neoplasms - immunology Lung Neoplasms - secondary Male Neuroblastoma - genetics Neuroblastoma - immunology Neuroblastoma - secondary Neuroblastoma - therapy NK cells pediatric solid tumors Receptors, KIR - genetics Remission Induction Rhabdomyosarcoma - genetics Rhabdomyosarcoma - immunology Rhabdomyosarcoma - secondary Rhabdomyosarcoma - therapy Sarcoma, Ewing - genetics Sarcoma, Ewing - immunology Sarcoma, Ewing - therapy Testicular Neoplasms - genetics Testicular Neoplasms - immunology Testicular Neoplasms - therapy |
| title | KIR-HLA receptor-ligand mismatch associated with a graft-versus-tumor effect in haploidentical stem cell transplantation for pediatric metastatic solid tumors |
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