BCL6: somatic mutations and expression in early-stage chronic lymphocytic leukemia

BCL6 somatic mutations affect normal and tumoral post germinal center B-lymphocytes. Our objective was to analyse expression, mutations and polymorphisms in the BCL6 gene and to correlate those variables with the clinical outcome in early-stage chronic lymphocytic leukemia (CLL). CLL samples were us...

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Veröffentlicht in:	Leukemia & lymphoma 2009-01, Vol.50 (5), p.773-780
Hauptverfasser:	Jantus Lewintre, Eloisa, Reinoso Martín, Cristina, García Ballesteros, Carlos, Pendas, Jehzabel, Benet Campos, Carmen, Mayans Ferrer, José Ramón, García-Conde, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over BCL6 CLL DNA-Binding Proteins - analysis DNA-Binding Proteins - genetics expression Female Genes, Immunoglobulin Humans IGHV Immunoglobulin Heavy Chains - genetics Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - genetics Male Middle Aged Mutation Point Mutation Polymorphism, Genetic polymorphisms Predictive Value of Tests Prognosis Proto-Oncogene Proteins c-bcl-6 somatic mutations Treatment Outcome
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