The Weiss system for evaluating adrenocortical neoplasms: 25 years later

Summary The evaluation and categorization of adrenocortical neoplasms remain among the most challenging areas in adrenal pathology. The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered...

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Veröffentlicht in:Human pathology 2009-06, Vol.40 (6), p.757-768
Hauptverfasser: Lau, Sean K., MD, Weiss, Lawrence M., MD
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description Summary The evaluation and categorization of adrenocortical neoplasms remain among the most challenging areas in adrenal pathology. The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered the standard for determining malignancy in tumors of the adrenal cortex. Considerable advances in the understanding of the pathology of adrenocortical neoplasia have occurred since delineation of the Weiss system, offering alternative approaches to the contemporary assessment of adrenocortical tumors.
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The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered the standard for determining malignancy in tumors of the adrenal cortex. Considerable advances in the understanding of the pathology of adrenocortical neoplasia have occurred since delineation of the Weiss system, offering alternative approaches to the contemporary assessment of adrenocortical tumors.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2009.03.010</identifier><identifier>PMID: 19442788</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenal cortex ; Adrenal Cortex - pathology ; Adrenal Cortex Neoplasms - classification ; Adrenal Cortex Neoplasms - genetics ; Adrenal Cortex Neoplasms - pathology ; Adrenal glands ; Adrenals. Adrenal axis. 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The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered the standard for determining malignancy in tumors of the adrenal cortex. Considerable advances in the understanding of the pathology of adrenocortical neoplasia have occurred since delineation of the Weiss system, offering alternative approaches to the contemporary assessment of adrenocortical tumors.</description><subject>Adrenal cortex</subject><subject>Adrenal Cortex - pathology</subject><subject>Adrenal Cortex Neoplasms - classification</subject><subject>Adrenal Cortex Neoplasms - genetics</subject><subject>Adrenal Cortex Neoplasms - pathology</subject><subject>Adrenal glands</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adrenocortical adenoma</subject><subject>Adrenocortical Adenoma - pathology</subject><subject>Adrenocortical carcinoma</subject><subject>Adrenocortical Carcinoma - pathology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Fine-Needle</subject><subject>Cell Nucleus - pathology</subject><subject>Child</subject><subject>Clinical medicine</subject><subject>Cytoplasm</subject><subject>Endocrinopathies</subject><subject>Genes, Neoplasm</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Mitosis</subject><subject>Necrosis</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adrenocortical adenoma</topic><topic>Adrenocortical Adenoma - pathology</topic><topic>Adrenocortical carcinoma</topic><topic>Adrenocortical Carcinoma - pathology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Fine-Needle</topic><topic>Cell Nucleus - pathology</topic><topic>Child</topic><topic>Clinical medicine</topic><topic>Cytoplasm</topic><topic>Endocrinopathies</topic><topic>Genes, Neoplasm</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Mitosis</topic><topic>Necrosis</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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subjects Adrenal cortex
Adrenal Cortex - pathology
Adrenal Cortex Neoplasms - classification
Adrenal Cortex Neoplasms - genetics
Adrenal Cortex Neoplasms - pathology
Adrenal glands
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adrenocortical adenoma
Adrenocortical Adenoma - pathology
Adrenocortical carcinoma
Adrenocortical Carcinoma - pathology
Adult
Biological and medical sciences
Biopsy, Fine-Needle
Cell Nucleus - pathology
Child
Clinical medicine
Cytoplasm
Endocrinopathies
Genes, Neoplasm
Humans
Immunohistochemistry
Investigative techniques, diagnostic techniques (general aspects)
Malignant tumors
Medical sciences
Mitosis
Necrosis
Neoplasm Invasiveness - pathology
Pathology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pediatrics
Prognosis
Tumors
Weiss system
title The Weiss system for evaluating adrenocortical neoplasms: 25 years later
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