The Weiss system for evaluating adrenocortical neoplasms: 25 years later
Summary The evaluation and categorization of adrenocortical neoplasms remain among the most challenging areas in adrenal pathology. The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered...
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Veröffentlicht in: | Human pathology 2009-06, Vol.40 (6), p.757-768 |
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description | Summary The evaluation and categorization of adrenocortical neoplasms remain among the most challenging areas in adrenal pathology. The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered the standard for determining malignancy in tumors of the adrenal cortex. Considerable advances in the understanding of the pathology of adrenocortical neoplasia have occurred since delineation of the Weiss system, offering alternative approaches to the contemporary assessment of adrenocortical tumors. |
doi_str_mv | 10.1016/j.humpath.2009.03.010 |
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The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered the standard for determining malignancy in tumors of the adrenal cortex. Considerable advances in the understanding of the pathology of adrenocortical neoplasia have occurred since delineation of the Weiss system, offering alternative approaches to the contemporary assessment of adrenocortical tumors.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2009.03.010</identifier><identifier>PMID: 19442788</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenal cortex ; Adrenal Cortex - pathology ; Adrenal Cortex Neoplasms - classification ; Adrenal Cortex Neoplasms - genetics ; Adrenal Cortex Neoplasms - pathology ; Adrenal glands ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adrenocortical adenoma ; Adrenocortical Adenoma - pathology ; Adrenocortical carcinoma ; Adrenocortical Carcinoma - pathology ; Adult ; Biological and medical sciences ; Biopsy, Fine-Needle ; Cell Nucleus - pathology ; Child ; Clinical medicine ; Cytoplasm ; Endocrinopathies ; Genes, Neoplasm ; Humans ; Immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Malignant tumors ; Medical sciences ; Mitosis ; Necrosis ; Neoplasm Invasiveness - pathology ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pediatrics ; Prognosis ; Tumors ; Weiss system</subject><ispartof>Human pathology, 2009-06, Vol.40 (6), p.757-768</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-fa1dd5a5e5676a2d718d90b4e120e85e1e42f8e5eb05308fc2e17f5970e8d50a3</citedby><cites>FETCH-LOGICAL-c476t-fa1dd5a5e5676a2d718d90b4e120e85e1e42f8e5eb05308fc2e17f5970e8d50a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.humpath.2009.03.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21549506$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19442788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lau, Sean K., MD</creatorcontrib><creatorcontrib>Weiss, Lawrence M., MD</creatorcontrib><title>The Weiss system for evaluating adrenocortical neoplasms: 25 years later</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary The evaluation and categorization of adrenocortical neoplasms remain among the most challenging areas in adrenal pathology. The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered the standard for determining malignancy in tumors of the adrenal cortex. Considerable advances in the understanding of the pathology of adrenocortical neoplasia have occurred since delineation of the Weiss system, offering alternative approaches to the contemporary assessment of adrenocortical tumors.</description><subject>Adrenal cortex</subject><subject>Adrenal Cortex - pathology</subject><subject>Adrenal Cortex Neoplasms - classification</subject><subject>Adrenal Cortex Neoplasms - genetics</subject><subject>Adrenal Cortex Neoplasms - pathology</subject><subject>Adrenal glands</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adrenocortical adenoma</subject><subject>Adrenocortical Adenoma - pathology</subject><subject>Adrenocortical carcinoma</subject><subject>Adrenocortical Carcinoma - pathology</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Fine-Needle</subject><subject>Cell Nucleus - pathology</subject><subject>Child</subject><subject>Clinical medicine</subject><subject>Cytoplasm</subject><subject>Endocrinopathies</subject><subject>Genes, Neoplasm</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Malignant tumors</subject><subject>Medical sciences</subject><subject>Mitosis</subject><subject>Necrosis</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Pediatrics</subject><subject>Prognosis</subject><subject>Tumors</subject><subject>Weiss system</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhi0EokvhJ4AiIXpLGDvxRziAUAUUqRIHijhaXmfCesnH1pNU2n9fRxtRqRdOPswzo9fPDGOvORQcuHq_L3Zzf3DTrhAAdQFlARyesA2XpchNWYunbANQqdxwrc_YC6I9AOeyks_ZGa-rSmhjNuzqZofZbwxEGR1pwj5rx5jhnetmN4XhT-aaiMPoxzgF77pswPHQOerpQyZkdkQXKevchPEle9a6jvDV-p6zX1-_3Fxe5dc_vn2__Hyd-0qrKW8dbxrpJEqllRON5qapYVshF4BGIsdKtAYlbkGWYFovkOtW1jpVGwmuPGcXp7mHON7OSJPtA3nsOpeizWSVFpXhSiTw7SNwP85xSNksh7Iy2iizUPJE-TgSRWztIYbexWOC7CLa7u0q2i6iLZQ2iU59b9bp87bH5qFrNZuAdyvgKIlroxt8oH-cSJuoJajEfTpxmKTdBYyWfMDBYxMi-sk2Y_hvlI-PJvguDMu2_uIR6eHXloQF-3O5iuUooAYAU8ryHmpvsmk</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Lau, Sean K., MD</creator><creator>Weiss, Lawrence M., MD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>The Weiss system for evaluating adrenocortical neoplasms: 25 years later</title><author>Lau, Sean K., MD ; Weiss, Lawrence M., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-fa1dd5a5e5676a2d718d90b4e120e85e1e42f8e5eb05308fc2e17f5970e8d50a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adrenal cortex</topic><topic>Adrenal Cortex - pathology</topic><topic>Adrenal Cortex Neoplasms - classification</topic><topic>Adrenal Cortex Neoplasms - genetics</topic><topic>Adrenal Cortex Neoplasms - pathology</topic><topic>Adrenal glands</topic><topic>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adrenocortical adenoma</topic><topic>Adrenocortical Adenoma - pathology</topic><topic>Adrenocortical carcinoma</topic><topic>Adrenocortical Carcinoma - pathology</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Fine-Needle</topic><topic>Cell Nucleus - pathology</topic><topic>Child</topic><topic>Clinical medicine</topic><topic>Cytoplasm</topic><topic>Endocrinopathies</topic><topic>Genes, Neoplasm</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Malignant tumors</topic><topic>Medical sciences</topic><topic>Mitosis</topic><topic>Necrosis</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Pediatrics</topic><topic>Prognosis</topic><topic>Tumors</topic><topic>Weiss system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lau, Sean K., MD</creatorcontrib><creatorcontrib>Weiss, Lawrence M., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lau, Sean K., MD</au><au>Weiss, Lawrence M., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Weiss system for evaluating adrenocortical neoplasms: 25 years later</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>40</volume><issue>6</issue><spage>757</spage><epage>768</epage><pages>757-768</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary The evaluation and categorization of adrenocortical neoplasms remain among the most challenging areas in adrenal pathology. The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered the standard for determining malignancy in tumors of the adrenal cortex. Considerable advances in the understanding of the pathology of adrenocortical neoplasia have occurred since delineation of the Weiss system, offering alternative approaches to the contemporary assessment of adrenocortical tumors.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19442788</pmid><doi>10.1016/j.humpath.2009.03.010</doi><tpages>12</tpages></addata></record> |
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subjects | Adrenal cortex Adrenal Cortex - pathology Adrenal Cortex Neoplasms - classification Adrenal Cortex Neoplasms - genetics Adrenal Cortex Neoplasms - pathology Adrenal glands Adrenals. Adrenal axis. Renin-angiotensin system (diseases) Adrenocortical adenoma Adrenocortical Adenoma - pathology Adrenocortical carcinoma Adrenocortical Carcinoma - pathology Adult Biological and medical sciences Biopsy, Fine-Needle Cell Nucleus - pathology Child Clinical medicine Cytoplasm Endocrinopathies Genes, Neoplasm Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Malignant tumors Medical sciences Mitosis Necrosis Neoplasm Invasiveness - pathology Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pediatrics Prognosis Tumors Weiss system |
title | The Weiss system for evaluating adrenocortical neoplasms: 25 years later |
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