Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells

Angiogenesis involves multiple steps including proliferation and migration of endothelial cells. In the present study, we determined the effect of inostamycin (an inhibitor of phosphatidylinositol synthesis) on vascular endothelial growth factor (VEGF)-induced proliferation and migration of human um...

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Veröffentlicht in:	Clinical & experimental metastasis 2004-01, Vol.21 (5), p.419-425
Hauptverfasser:	Baba, Yuh, Kato, Yasumasa, Mochimatsu, Izumi, Nagashima, Yoji, Kurihara, Miki, Kawano, Toshiro, Taguchi, Takahide, Hata, Ryu-Ichiro, Tsukuda, Mamoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Cyclin D1 - pharmacology Endothelial Cells - drug effects Furans - pharmacology Humans Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Umbilical Veins - drug effects Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor A - pharmacology
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