Hickman catheter site infections after allogeneic stem cell transplantation: Single-center experience
Hickman catheter site infections are known to increase transplant-related mortality (TRM). A retrospective analysis of 103 patients who received allogeneic SCT (stem cell transplants) was performed to define the incidence and outcomes of Hickman infections. Seventy-six patients received peripheral b...
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| Veröffentlicht in: | Transplantation proceedings 2004-12, Vol.36 (10), p.3203-3207 |
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| creator | Kim, D.H. Bae, N.Y. Sung, W.J. Kim, J.G. Kim, S.W. Sohn, S.K. Lee, K.B. |
| description | Hickman catheter site infections are known to increase transplant-related mortality (TRM). A retrospective analysis of 103 patients who received allogeneic SCT (stem cell transplants) was performed to define the incidence and outcomes of Hickman infections. Seventy-six patients received peripheral blood stem cells (PBSCs) (73.8%) and 29 patients (28.2%), nonmyeloablative conditioning. During the median follow-up of 9 months, Hickman infections were observed in 10 patients (9.7%) at a median onset of 32 days posttransplantation (range, 2–102 days). The causative organisms were identified in 5 cases, including
Staphylococcus species (n = 4) and
Pseudomonas aeruginosa (n = 1). Six events were successfully resolved with antibiotic treatment, whereas the other 4 events required the removal of the Hickman catheters with subsequent death in 2 cases. The survival duration for the Hickman infection group was shorter than that for the Hickman no infection group (83 days vs 366 days, respectively;
P < .001). Myeloid engraftment was delayed in the Hickman infection group (18.0 days vs 15.0 days, respectively;
P = .038), plus Hickman infections were more frequent among BMT compared with PBSCT group (22.2% vs 5.3%, respectively,
P = .019). Hickman infections were associated with TRM, especially during the first 3 months posttransplantation. As such, the current results emphasize both the importance of Hickman catheter care and the need for surveillance cultures after SCT. |
| doi_str_mv | 10.1016/j.transproceed.2004.10.089 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67246533</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0041134504012886</els_id><sourcerecordid>67246533</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-3fd6c1833a6be9cf4fd6b99a232442fce27e8a2e4acc4f77c0166c8e8b7f4f0a3</originalsourceid><addsrcrecordid>eNqNkE1vEzEQhi0EoqHlL1SrSnDb4K94vb2h8lGkShygZ8uZjFunu97UdhD8e2ZJRDlyssbvM-Pxw9iF4EvBhXm3XdbsU9nlCRA3S8m5pmDJbf-MLYTtVCuNVM_ZggLRCqVXJ-xVKVtOtdTqJTsRK2NNJ_sFw-sID6NPDfh6jxVzU2LFJqaAUOOUSuPDfOuHYbrDhBGaUnFsAIehOawx-FT9zF4232K6G7AFTHMP_txhjpgAz9iL4IeCr4_nKbv99PH71XV78_Xzl6v3Ny1obmurwsaAsEp5s8YegqZ63fdeKqm1DICyQ-slag-gQ9cB2TBg0a47YrlXp-ztYS65edxjqW6MZV7VJ5z2xdGftVkpReDlAYQ8lZIxuF2Oo8-_nOBuluy27l_JbpY8ZySZms-Pr-zXI2V_W49WCXhzBHwBPwQaBLE8cUZb1QtN3IcDh-TkR8TsCvzxtYmZ9LvNFP9nn98v7aTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67246533</pqid></control><display><type>article</type><title>Hickman catheter site infections after allogeneic stem cell transplantation: Single-center experience</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kim, D.H. ; Bae, N.Y. ; Sung, W.J. ; Kim, J.G. ; Kim, S.W. ; Sohn, S.K. ; Lee, K.B.</creator><creatorcontrib>Kim, D.H. ; Bae, N.Y. ; Sung, W.J. ; Kim, J.G. ; Kim, S.W. ; Sohn, S.K. ; Lee, K.B.</creatorcontrib><description>Hickman catheter site infections are known to increase transplant-related mortality (TRM). A retrospective analysis of 103 patients who received allogeneic SCT (stem cell transplants) was performed to define the incidence and outcomes of Hickman infections. Seventy-six patients received peripheral blood stem cells (PBSCs) (73.8%) and 29 patients (28.2%), nonmyeloablative conditioning. During the median follow-up of 9 months, Hickman infections were observed in 10 patients (9.7%) at a median onset of 32 days posttransplantation (range, 2–102 days). The causative organisms were identified in 5 cases, including
Staphylococcus species (n = 4) and
Pseudomonas aeruginosa (n = 1). Six events were successfully resolved with antibiotic treatment, whereas the other 4 events required the removal of the Hickman catheters with subsequent death in 2 cases. The survival duration for the Hickman infection group was shorter than that for the Hickman no infection group (83 days vs 366 days, respectively;
P < .001). Myeloid engraftment was delayed in the Hickman infection group (18.0 days vs 15.0 days, respectively;
P = .038), plus Hickman infections were more frequent among BMT compared with PBSCT group (22.2% vs 5.3%, respectively,
P = .019). Hickman infections were associated with TRM, especially during the first 3 months posttransplantation. As such, the current results emphasize both the importance of Hickman catheter care and the need for surveillance cultures after SCT.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2004.10.089</identifier><identifier>PMID: 15686729</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Bacterial Infections - epidemiology ; Biological and medical sciences ; Catheterization, Central Venous - adverse effects ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Leukemia, Myeloid - therapy ; Male ; Medical sciences ; Middle Aged ; Multiple Myeloma - therapy ; Myelodysplastic Syndromes - therapy ; Pseudomonas aeruginosa ; Pseudomonas Infections - epidemiology ; Retrospective Studies ; Staphylococcal Infections - epidemiology ; Stem Cell Transplantation - adverse effects ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Transplantation, Homologous</subject><ispartof>Transplantation proceedings, 2004-12, Vol.36 (10), p.3203-3207</ispartof><rights>2004 Elsevier Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-3fd6c1833a6be9cf4fd6b99a232442fce27e8a2e4acc4f77c0166c8e8b7f4f0a3</citedby><cites>FETCH-LOGICAL-c408t-3fd6c1833a6be9cf4fd6b99a232442fce27e8a2e4acc4f77c0166c8e8b7f4f0a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2004.10.089$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16483914$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15686729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, D.H.</creatorcontrib><creatorcontrib>Bae, N.Y.</creatorcontrib><creatorcontrib>Sung, W.J.</creatorcontrib><creatorcontrib>Kim, J.G.</creatorcontrib><creatorcontrib>Kim, S.W.</creatorcontrib><creatorcontrib>Sohn, S.K.</creatorcontrib><creatorcontrib>Lee, K.B.</creatorcontrib><title>Hickman catheter site infections after allogeneic stem cell transplantation: Single-center experience</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Hickman catheter site infections are known to increase transplant-related mortality (TRM). A retrospective analysis of 103 patients who received allogeneic SCT (stem cell transplants) was performed to define the incidence and outcomes of Hickman infections. Seventy-six patients received peripheral blood stem cells (PBSCs) (73.8%) and 29 patients (28.2%), nonmyeloablative conditioning. During the median follow-up of 9 months, Hickman infections were observed in 10 patients (9.7%) at a median onset of 32 days posttransplantation (range, 2–102 days). The causative organisms were identified in 5 cases, including
Staphylococcus species (n = 4) and
Pseudomonas aeruginosa (n = 1). Six events were successfully resolved with antibiotic treatment, whereas the other 4 events required the removal of the Hickman catheters with subsequent death in 2 cases. The survival duration for the Hickman infection group was shorter than that for the Hickman no infection group (83 days vs 366 days, respectively;
P < .001). Myeloid engraftment was delayed in the Hickman infection group (18.0 days vs 15.0 days, respectively;
P = .038), plus Hickman infections were more frequent among BMT compared with PBSCT group (22.2% vs 5.3%, respectively,
P = .019). Hickman infections were associated with TRM, especially during the first 3 months posttransplantation. As such, the current results emphasize both the importance of Hickman catheter care and the need for surveillance cultures after SCT.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bacterial Infections - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Leukemia, Myeloid - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Myeloma - therapy</subject><subject>Myelodysplastic Syndromes - therapy</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas Infections - epidemiology</subject><subject>Retrospective Studies</subject><subject>Staphylococcal Infections - epidemiology</subject><subject>Stem Cell Transplantation - adverse effects</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1vEzEQhi0EoqHlL1SrSnDb4K94vb2h8lGkShygZ8uZjFunu97UdhD8e2ZJRDlyssbvM-Pxw9iF4EvBhXm3XdbsU9nlCRA3S8m5pmDJbf-MLYTtVCuNVM_ZggLRCqVXJ-xVKVtOtdTqJTsRK2NNJ_sFw-sID6NPDfh6jxVzU2LFJqaAUOOUSuPDfOuHYbrDhBGaUnFsAIehOawx-FT9zF4232K6G7AFTHMP_txhjpgAz9iL4IeCr4_nKbv99PH71XV78_Xzl6v3Ny1obmurwsaAsEp5s8YegqZ63fdeKqm1DICyQ-slag-gQ9cB2TBg0a47YrlXp-ztYS65edxjqW6MZV7VJ5z2xdGftVkpReDlAYQ8lZIxuF2Oo8-_nOBuluy27l_JbpY8ZySZms-Pr-zXI2V_W49WCXhzBHwBPwQaBLE8cUZb1QtN3IcDh-TkR8TsCvzxtYmZ9LvNFP9nn98v7aTg</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Kim, D.H.</creator><creator>Bae, N.Y.</creator><creator>Sung, W.J.</creator><creator>Kim, J.G.</creator><creator>Kim, S.W.</creator><creator>Sohn, S.K.</creator><creator>Lee, K.B.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Hickman catheter site infections after allogeneic stem cell transplantation: Single-center experience</title><author>Kim, D.H. ; Bae, N.Y. ; Sung, W.J. ; Kim, J.G. ; Kim, S.W. ; Sohn, S.K. ; Lee, K.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-3fd6c1833a6be9cf4fd6b99a232442fce27e8a2e4acc4f77c0166c8e8b7f4f0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bacterial Infections - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Leukemia, Myeloid - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Myeloma - therapy</topic><topic>Myelodysplastic Syndromes - therapy</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas Infections - epidemiology</topic><topic>Retrospective Studies</topic><topic>Staphylococcal Infections - epidemiology</topic><topic>Stem Cell Transplantation - adverse effects</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, D.H.</creatorcontrib><creatorcontrib>Bae, N.Y.</creatorcontrib><creatorcontrib>Sung, W.J.</creatorcontrib><creatorcontrib>Kim, J.G.</creatorcontrib><creatorcontrib>Kim, S.W.</creatorcontrib><creatorcontrib>Sohn, S.K.</creatorcontrib><creatorcontrib>Lee, K.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, D.H.</au><au>Bae, N.Y.</au><au>Sung, W.J.</au><au>Kim, J.G.</au><au>Kim, S.W.</au><au>Sohn, S.K.</au><au>Lee, K.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hickman catheter site infections after allogeneic stem cell transplantation: Single-center experience</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>36</volume><issue>10</issue><spage>3203</spage><epage>3207</epage><pages>3203-3207</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Hickman catheter site infections are known to increase transplant-related mortality (TRM). A retrospective analysis of 103 patients who received allogeneic SCT (stem cell transplants) was performed to define the incidence and outcomes of Hickman infections. Seventy-six patients received peripheral blood stem cells (PBSCs) (73.8%) and 29 patients (28.2%), nonmyeloablative conditioning. During the median follow-up of 9 months, Hickman infections were observed in 10 patients (9.7%) at a median onset of 32 days posttransplantation (range, 2–102 days). The causative organisms were identified in 5 cases, including
Staphylococcus species (n = 4) and
Pseudomonas aeruginosa (n = 1). Six events were successfully resolved with antibiotic treatment, whereas the other 4 events required the removal of the Hickman catheters with subsequent death in 2 cases. The survival duration for the Hickman infection group was shorter than that for the Hickman no infection group (83 days vs 366 days, respectively;
P < .001). Myeloid engraftment was delayed in the Hickman infection group (18.0 days vs 15.0 days, respectively;
P = .038), plus Hickman infections were more frequent among BMT compared with PBSCT group (22.2% vs 5.3%, respectively,
P = .019). Hickman infections were associated with TRM, especially during the first 3 months posttransplantation. As such, the current results emphasize both the importance of Hickman catheter care and the need for surveillance cultures after SCT.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15686729</pmid><doi>10.1016/j.transproceed.2004.10.089</doi><tpages>5</tpages></addata></record> |
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| ispartof | Transplantation proceedings, 2004-12, Vol.36 (10), p.3203-3207 |
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| subjects | Adolescent Adult Bacterial Infections - epidemiology Biological and medical sciences Catheterization, Central Venous - adverse effects Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Leukemia, Myeloid - therapy Male Medical sciences Middle Aged Multiple Myeloma - therapy Myelodysplastic Syndromes - therapy Pseudomonas aeruginosa Pseudomonas Infections - epidemiology Retrospective Studies Staphylococcal Infections - epidemiology Stem Cell Transplantation - adverse effects Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Transplantation, Homologous |
| title | Hickman catheter site infections after allogeneic stem cell transplantation: Single-center experience |
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