BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1
Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) activates NF-kappaB signaling pathways through the two C-terminal regions, CTAR1 and CTAR2. BS69 has previously been shown to be involved in LMP1-induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis fact...
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| Veröffentlicht in: | FEBS letters 2009-05, Vol.583 (10), p.1567-1574 |
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| container_title | FEBS letters |
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| creator | Ikeda, Osamu Sekine, Yuichi Mizushima, Akihiro Oritani, Kenji Yasui, Teruhito Fujimuro, Masahiro Muromoto, Ryuta Nanbo, Asuka Matsuda, Tadashi |
| description | Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) activates NF-kappaB signaling pathways through the two C-terminal regions, CTAR1 and CTAR2. BS69 has previously been shown to be involved in LMP1-induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis factor (TNFR) receptor-associated factor 6. In the present study, our manipulation of BS69 expression clearly indicates that BS69 negatively regulates LMP1-mediated NF-kappaB activation and up-regulates IL-6 mRNA expression and IkappaB degradation. Our immunoprecipitation experiments suggest that BS69 decreases complex formation between LMP1 and TNFR-associated death domain protein (TRADD). |
| doi_str_mv | 10.1016/j.febslet.2009.04.022 |
| format | Article |
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Our immunoprecipitation experiments suggest that BS69 decreases complex formation between LMP1 and TNFR-associated death domain protein (TRADD).</description><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2009.04.022</identifier><identifier>PMID: 19379743</identifier><language>eng</language><publisher>England</publisher><subject>Carrier Proteins - analysis ; Carrier Proteins - metabolism ; Cells, Cultured ; Gene Expression Regulation ; HeLa Cells ; Humans ; Interleukin-6 - genetics ; Interleukin-6 - metabolism ; Microscopy, Fluorescence ; Models, Biological ; NF-kappa B - analysis ; NF-kappa B - metabolism ; Signal Transduction ; TNF Receptor-Associated Death Domain Protein - metabolism ; Viral Matrix Proteins - analysis ; Viral Matrix Proteins - metabolism</subject><ispartof>FEBS letters, 2009-05, Vol.583 (10), p.1567-1574</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19379743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ikeda, Osamu</creatorcontrib><creatorcontrib>Sekine, Yuichi</creatorcontrib><creatorcontrib>Mizushima, Akihiro</creatorcontrib><creatorcontrib>Oritani, Kenji</creatorcontrib><creatorcontrib>Yasui, Teruhito</creatorcontrib><creatorcontrib>Fujimuro, Masahiro</creatorcontrib><creatorcontrib>Muromoto, Ryuta</creatorcontrib><creatorcontrib>Nanbo, Asuka</creatorcontrib><creatorcontrib>Matsuda, Tadashi</creatorcontrib><title>BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) activates NF-kappaB signaling pathways through the two C-terminal regions, CTAR1 and CTAR2. BS69 has previously been shown to be involved in LMP1-induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis factor (TNFR) receptor-associated factor 6. In the present study, our manipulation of BS69 expression clearly indicates that BS69 negatively regulates LMP1-mediated NF-kappaB activation and up-regulates IL-6 mRNA expression and IkappaB degradation. Our immunoprecipitation experiments suggest that BS69 decreases complex formation between LMP1 and TNFR-associated death domain protein (TRADD).</description><subject>Carrier Proteins - analysis</subject><subject>Carrier Proteins - metabolism</subject><subject>Cells, Cultured</subject><subject>Gene Expression Regulation</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Interleukin-6 - genetics</subject><subject>Interleukin-6 - metabolism</subject><subject>Microscopy, Fluorescence</subject><subject>Models, Biological</subject><subject>NF-kappa B - analysis</subject><subject>NF-kappa B - metabolism</subject><subject>Signal Transduction</subject><subject>TNF Receptor-Associated Death Domain Protein - metabolism</subject><subject>Viral Matrix Proteins - analysis</subject><subject>Viral Matrix Proteins - metabolism</subject><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10F1LwzAYBeAgiJvTn6DkyrvWpEnT5tKNTYX5Ae6-vEnezs6urUk72L9fwXl1bh4OnEPIHWcxZ1w97uISTaixjxPGdMxkzJLkgkx5nolISJVPyHUIO8YYz7m-IhOuRaYzKaZkO_9Smja4hb46YH2kHrdDDT0G2n8jtdC0TWWhpu-r6Ae6DuYU7EhH3ja0atxg0VFzpMsu9Fg10Ry8p4fKDyFy6MdOR9dvn_yGXJZQB7w954xsVsvN4iVafzy_Lp7WUZdKETlmNGhVKitkqqBMpXVJZrgz3OSJS0CpLNOWMyGMLJXOFUKaCqeEFSViKWbk4a-28-3vgKEv9lWwWNfQYDuEQmWJVOP6Ed6f4WD26IrOV3vwx-L_GXEC7OdmWw</recordid><startdate>20090519</startdate><enddate>20090519</enddate><creator>Ikeda, Osamu</creator><creator>Sekine, Yuichi</creator><creator>Mizushima, Akihiro</creator><creator>Oritani, Kenji</creator><creator>Yasui, Teruhito</creator><creator>Fujimuro, Masahiro</creator><creator>Muromoto, Ryuta</creator><creator>Nanbo, Asuka</creator><creator>Matsuda, Tadashi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20090519</creationdate><title>BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1</title><author>Ikeda, Osamu ; Sekine, Yuichi ; Mizushima, Akihiro ; Oritani, Kenji ; Yasui, Teruhito ; Fujimuro, Masahiro ; Muromoto, Ryuta ; Nanbo, Asuka ; Matsuda, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p543-d0b9a96f6c3456af54cd27b1db1b82d2a66779c1033b4f6986ea553d63c3feef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Carrier Proteins - analysis</topic><topic>Carrier Proteins - metabolism</topic><topic>Cells, Cultured</topic><topic>Gene Expression Regulation</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Interleukin-6 - genetics</topic><topic>Interleukin-6 - metabolism</topic><topic>Microscopy, Fluorescence</topic><topic>Models, Biological</topic><topic>NF-kappa B - analysis</topic><topic>NF-kappa B - metabolism</topic><topic>Signal Transduction</topic><topic>TNF Receptor-Associated Death Domain Protein - metabolism</topic><topic>Viral Matrix Proteins - analysis</topic><topic>Viral Matrix Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ikeda, Osamu</creatorcontrib><creatorcontrib>Sekine, Yuichi</creatorcontrib><creatorcontrib>Mizushima, Akihiro</creatorcontrib><creatorcontrib>Oritani, Kenji</creatorcontrib><creatorcontrib>Yasui, Teruhito</creatorcontrib><creatorcontrib>Fujimuro, Masahiro</creatorcontrib><creatorcontrib>Muromoto, Ryuta</creatorcontrib><creatorcontrib>Nanbo, Asuka</creatorcontrib><creatorcontrib>Matsuda, Tadashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ikeda, Osamu</au><au>Sekine, Yuichi</au><au>Mizushima, Akihiro</au><au>Oritani, Kenji</au><au>Yasui, Teruhito</au><au>Fujimuro, Masahiro</au><au>Muromoto, Ryuta</au><au>Nanbo, Asuka</au><au>Matsuda, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2009-05-19</date><risdate>2009</risdate><volume>583</volume><issue>10</issue><spage>1567</spage><epage>1574</epage><pages>1567-1574</pages><eissn>1873-3468</eissn><abstract>Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) activates NF-kappaB signaling pathways through the two C-terminal regions, CTAR1 and CTAR2. BS69 has previously been shown to be involved in LMP1-induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis factor (TNFR) receptor-associated factor 6. In the present study, our manipulation of BS69 expression clearly indicates that BS69 negatively regulates LMP1-mediated NF-kappaB activation and up-regulates IL-6 mRNA expression and IkappaB degradation. Our immunoprecipitation experiments suggest that BS69 decreases complex formation between LMP1 and TNFR-associated death domain protein (TRADD).</abstract><cop>England</cop><pmid>19379743</pmid><doi>10.1016/j.febslet.2009.04.022</doi><tpages>8</tpages></addata></record> |
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| ispartof | FEBS letters, 2009-05, Vol.583 (10), p.1567-1574 |
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| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Carrier Proteins - analysis Carrier Proteins - metabolism Cells, Cultured Gene Expression Regulation HeLa Cells Humans Interleukin-6 - genetics Interleukin-6 - metabolism Microscopy, Fluorescence Models, Biological NF-kappa B - analysis NF-kappa B - metabolism Signal Transduction TNF Receptor-Associated Death Domain Protein - metabolism Viral Matrix Proteins - analysis Viral Matrix Proteins - metabolism |
| title | BS69 negatively regulates the canonical NF-kappaB activation induced by Epstein-Barr virus-derived LMP1 |
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