An Imaging-Based Rapid Evaluation Method for Complement-Dependent Cytotoxicity Discriminated Clinical Response to Rituximab-Containing Chemotherapy

Purpose: Rituximab has greatly improved the efficacy of chemotherapy regimens for CD20-positive non-Hodgkin's lymphoma. However, although several mechanisms of action of rituximab have been identified, the exact therapeutic functions of these mechanisms remains to be clarified. In addition, the...

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Veröffentlicht in:	Clinical cancer research 2009-05, Vol.15 (10), p.3624-3632
Hauptverfasser:	MISHIMA, Yuji, SUGIMURA, Natsuhiko, HATAKE, Kiyohiko, MATSUMOTO-MISHIMA, Yuko, TERUI, Yasuhito, TAKEUCHI, Kengo, ASAI, Suzuka, ENNISHI, Daisuke, ASAI, Hiroaki, YOKOYAMA, Masahiro, KOJIMA, Kiyotsugu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - immunology Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Complement System Proteins - immunology Complement-dependent cytotoxicity (CDC) Cytotoxicity, Immunologic - drug effects Cytotoxicity, Immunologic - immunology Female Fluorescent Antibody Technique - methods Humans live cell imaging Lymph Nodes - drug effects Lymph Nodes - immunology Lymph Nodes - pathology Lymphocytes - drug effects Lymphocytes - immunology Lymphocytes - pathology Lymphoma, Follicular - drug therapy Lymphoma, Follicular - immunology Lymphoma, Follicular - pathology Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - pathology Male Medical sciences Middle Aged Outcome Assessment (Health Care) - methods Pharmacology. Drug treatments Reproducibility of Results Rituximab ROC Curve Treatment Outcome
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