Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

Mitochondrial dysregulation is strongly implicated in Parkinson disease. Mutations in PTEN-induced kinase 1 (PINK1) are associated with familial parkinsonism and neuropsychiatric disorders. Although overexpressed PINK1 is neuroprotective, less is known about neuronal responses to loss of PINK1 funct...

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Veröffentlicht in:	The Journal of biological chemistry 2009-05, Vol.284 (20), p.13843-13855
Hauptverfasser:	Dagda, Ruben K., Cherra, Salvatore J., Kulich, Scott M., Tandon, Anurag, Park, David, Chu, Charleen T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - physiology Autophagy-Related Protein 7 Gene Knockdown Techniques Homeostasis - physiology Humans Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitochondria - genetics Mitochondria - metabolism Oxidative Stress - physiology Parkinson Disease - genetics Parkinson Disease - metabolism Protein Kinases - genetics Protein Kinases - metabolism Ubiquitin-Activating Enzymes - genetics Ubiquitin-Activating Enzymes - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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