Heat loss during exercise is related to serotonin activity in the preoptic area
To investigate the influence of the central cholinergic system on thermoregulation and brain serotonin concentration during exercise; 2 μl of physostigmine (5×10 M) or saline solution was injected into the lateral cerebral ventricle of running rats. At fatigue, brains were quickly removed and seroto...
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| Veröffentlicht in: | Neuroreport 2009-05, Vol.20 (8), p.804-808 |
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| creator | Rodrigues, Alex G Soares, Danusa D Marubayashi, Umeko Coimbra, Cândido Celso |
| description | To investigate the influence of the central cholinergic system on thermoregulation and brain serotonin concentration during exercise; 2 μl of physostigmine (5×10 M) or saline solution was injected into the lateral cerebral ventricle of running rats. At fatigue, brains were quickly removed and serotonin and 5-hydroxyindoleacetic acid were measured in the preoptic area, hypothalamus, frontal cortex, and hippocampus. Physostigmine injection attenuated hyperthermia and exercise-induced heat storage that was closely related to the serotonin content in the preoptic area. Physostigmine treatment also increased the heat dissipation by decreasing core temperature threshold for vasodilation. In conclusion, our data indicated that stimulation of the central cholinergic system promotes heat dissipation in running rats that is related to decreased serotonin content in the preoptic area. |
| doi_str_mv | 10.1097/WNR.0b013e32832b8c90 |
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At fatigue, brains were quickly removed and serotonin and 5-hydroxyindoleacetic acid were measured in the preoptic area, hypothalamus, frontal cortex, and hippocampus. Physostigmine injection attenuated hyperthermia and exercise-induced heat storage that was closely related to the serotonin content in the preoptic area. Physostigmine treatment also increased the heat dissipation by decreasing core temperature threshold for vasodilation. In conclusion, our data indicated that stimulation of the central cholinergic system promotes heat dissipation in running rats that is related to decreased serotonin content in the preoptic area.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/WNR.0b013e32832b8c90</identifier><identifier>PMID: 19369904</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Acetylcholine - metabolism ; Animals ; Biological and medical sciences ; Body Temperature - drug effects ; Body Temperature - physiology ; Body Temperature Regulation - drug effects ; Body Temperature Regulation - physiology ; Cholinesterase Inhibitors - pharmacology ; Fever - metabolism ; Fever - physiopathology ; Frontal Lobe - metabolism ; Fundamental and applied biological sciences. Psychology ; Hippocampus - metabolism ; Hypothalamus - metabolism ; Male ; Physical Conditioning, Animal - physiology ; Physostigmine - pharmacology ; Preoptic Area - metabolism ; Rats ; Rats, Wistar ; Serotonin - metabolism ; Thermoregulation. Hibernation. Estivation. 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At fatigue, brains were quickly removed and serotonin and 5-hydroxyindoleacetic acid were measured in the preoptic area, hypothalamus, frontal cortex, and hippocampus. Physostigmine injection attenuated hyperthermia and exercise-induced heat storage that was closely related to the serotonin content in the preoptic area. Physostigmine treatment also increased the heat dissipation by decreasing core temperature threshold for vasodilation. In conclusion, our data indicated that stimulation of the central cholinergic system promotes heat dissipation in running rats that is related to decreased serotonin content in the preoptic area.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Body Temperature - physiology</subject><subject>Body Temperature Regulation - drug effects</subject><subject>Body Temperature Regulation - physiology</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Fever - metabolism</subject><subject>Fever - physiopathology</subject><subject>Frontal Lobe - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - metabolism</subject><subject>Hypothalamus - metabolism</subject><subject>Male</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physostigmine - pharmacology</subject><subject>Preoptic Area - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serotonin - metabolism</subject><subject>Thermoregulation. Hibernation. Estivation. 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Psychology</topic><topic>Hippocampus - metabolism</topic><topic>Hypothalamus - metabolism</topic><topic>Male</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physostigmine - pharmacology</topic><topic>Preoptic Area - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Serotonin - metabolism</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - physiology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodrigues, Alex G</creatorcontrib><creatorcontrib>Soares, Danusa D</creatorcontrib><creatorcontrib>Marubayashi, Umeko</creatorcontrib><creatorcontrib>Coimbra, Cândido Celso</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodrigues, Alex G</au><au>Soares, Danusa D</au><au>Marubayashi, Umeko</au><au>Coimbra, Cândido Celso</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heat loss during exercise is related to serotonin activity in the preoptic area</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2009-05-27</date><risdate>2009</risdate><volume>20</volume><issue>8</issue><spage>804</spage><epage>808</epage><pages>804-808</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>To investigate the influence of the central cholinergic system on thermoregulation and brain serotonin concentration during exercise; 2 μl of physostigmine (5×10 M) or saline solution was injected into the lateral cerebral ventricle of running rats. At fatigue, brains were quickly removed and serotonin and 5-hydroxyindoleacetic acid were measured in the preoptic area, hypothalamus, frontal cortex, and hippocampus. Physostigmine injection attenuated hyperthermia and exercise-induced heat storage that was closely related to the serotonin content in the preoptic area. Physostigmine treatment also increased the heat dissipation by decreasing core temperature threshold for vasodilation. In conclusion, our data indicated that stimulation of the central cholinergic system promotes heat dissipation in running rats that is related to decreased serotonin content in the preoptic area.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19369904</pmid><doi>10.1097/WNR.0b013e32832b8c90</doi><tpages>5</tpages></addata></record> |
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| subjects | Acetylcholine - metabolism Animals Biological and medical sciences Body Temperature - drug effects Body Temperature - physiology Body Temperature Regulation - drug effects Body Temperature Regulation - physiology Cholinesterase Inhibitors - pharmacology Fever - metabolism Fever - physiopathology Frontal Lobe - metabolism Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Hypothalamus - metabolism Male Physical Conditioning, Animal - physiology Physostigmine - pharmacology Preoptic Area - metabolism Rats Rats, Wistar Serotonin - metabolism Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vasodilation - drug effects Vasodilation - physiology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Heat loss during exercise is related to serotonin activity in the preoptic area |
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