Gonadotrophin Inhibitory Hormone Depresses Gonadotrophin α and Follicle-Stimulating Hormone β Subunit Expression in the Pituitary of the Domestic Chicken
Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest‐deprived incubatin...
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| Veröffentlicht in: | Journal of neuroendocrinology 2004-12, Vol.16 (12), p.999-1006 |
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| creator | Ciccone, N. A. Dunn, I. C. Boswell, T. Tsutsui, K. Ubuka, T. Ukena, K. Sharp, P. J. |
| description | Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest‐deprived incubating hens failed to depress the concentration of plasma luteinizing hormone (LH). Addition of GnIH to short‐term (120 min) cultures of diced pituitary glands from adult cockerels depressed follicle‐stimulating hormone (FSH) and LH release and depressed common α and FSHβ gonadotrophin subunit mRNAs, with no effect on LHβ subunit mRNA. Hypothalamic GnIH mRNA was higher in incubating (out‐of‐lay) than in laying hens, but there was no significant difference in the amount of hypothalamic GnIH mRNA in out‐of‐lay and laying broiler breeder hens at the end of a laying year. It is concluded that avian GnIH may play a role in controlling gonadotrophin synthesis and associated constitutive release in the domestic chicken. |
| doi_str_mv | 10.1111/j.1365-2826.2005.01260.x |
| format | Article |
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A. ; Dunn, I. C. ; Boswell, T. ; Tsutsui, K. ; Ubuka, T. ; Ukena, K. ; Sharp, P. J.</creator><creatorcontrib>Ciccone, N. A. ; Dunn, I. C. ; Boswell, T. ; Tsutsui, K. ; Ubuka, T. ; Ukena, K. ; Sharp, P. J.</creatorcontrib><description>Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest‐deprived incubating hens failed to depress the concentration of plasma luteinizing hormone (LH). Addition of GnIH to short‐term (120 min) cultures of diced pituitary glands from adult cockerels depressed follicle‐stimulating hormone (FSH) and LH release and depressed common α and FSHβ gonadotrophin subunit mRNAs, with no effect on LHβ subunit mRNA. Hypothalamic GnIH mRNA was higher in incubating (out‐of‐lay) than in laying hens, but there was no significant difference in the amount of hypothalamic GnIH mRNA in out‐of‐lay and laying broiler breeder hens at the end of a laying year. It is concluded that avian GnIH may play a role in controlling gonadotrophin synthesis and associated constitutive release in the domestic chicken.</description><identifier>ISSN: 0953-8194</identifier><identifier>EISSN: 1365-2826</identifier><identifier>DOI: 10.1111/j.1365-2826.2005.01260.x</identifier><identifier>PMID: 15667455</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Animals ; Avian Proteins - physiology ; Biological and medical sciences ; chicken ; Chickens ; Female ; Follicle Stimulating Hormone, beta Subunit - genetics ; Follicle Stimulating Hormone, beta Subunit - metabolism ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Glycoprotein Hormones, alpha Subunit - genetics ; Glycoprotein Hormones, alpha Subunit - metabolism ; GnIH ; gonadotrophin mRNAs ; Hypothalamic Hormones - physiology ; hypothalamus ; In Vitro Techniques ; Luteinizing Hormone - blood ; Male ; Nesting Behavior - physiology ; Ovary - metabolism ; Pituitary Gland, Anterior - metabolism ; reproduction ; Reproduction - physiology ; RNA, Messenger - analysis ; Sex Factors ; Vertebrates: endocrinology</subject><ispartof>Journal of neuroendocrinology, 2004-12, Vol.16 (12), p.999-1006</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4660-84f6d641633c3b33303d5c7366cb670637bb0aca8623acdc3cc8294a19c268ab3</citedby><cites>FETCH-LOGICAL-c4660-84f6d641633c3b33303d5c7366cb670637bb0aca8623acdc3cc8294a19c268ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2826.2005.01260.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2826.2005.01260.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16422981$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15667455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ciccone, N. A.</creatorcontrib><creatorcontrib>Dunn, I. C.</creatorcontrib><creatorcontrib>Boswell, T.</creatorcontrib><creatorcontrib>Tsutsui, K.</creatorcontrib><creatorcontrib>Ubuka, T.</creatorcontrib><creatorcontrib>Ukena, K.</creatorcontrib><creatorcontrib>Sharp, P. J.</creatorcontrib><title>Gonadotrophin Inhibitory Hormone Depresses Gonadotrophin α and Follicle-Stimulating Hormone β Subunit Expression in the Pituitary of the Domestic Chicken</title><title>Journal of neuroendocrinology</title><addtitle>J Neuroendocrinol</addtitle><description>Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest‐deprived incubating hens failed to depress the concentration of plasma luteinizing hormone (LH). Addition of GnIH to short‐term (120 min) cultures of diced pituitary glands from adult cockerels depressed follicle‐stimulating hormone (FSH) and LH release and depressed common α and FSHβ gonadotrophin subunit mRNAs, with no effect on LHβ subunit mRNA. Hypothalamic GnIH mRNA was higher in incubating (out‐of‐lay) than in laying hens, but there was no significant difference in the amount of hypothalamic GnIH mRNA in out‐of‐lay and laying broiler breeder hens at the end of a laying year. It is concluded that avian GnIH may play a role in controlling gonadotrophin synthesis and associated constitutive release in the domestic chicken.</description><subject>Animals</subject><subject>Avian Proteins - physiology</subject><subject>Biological and medical sciences</subject><subject>chicken</subject><subject>Chickens</subject><subject>Female</subject><subject>Follicle Stimulating Hormone, beta Subunit - genetics</subject><subject>Follicle Stimulating Hormone, beta Subunit - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Glycoprotein Hormones, alpha Subunit - genetics</subject><subject>Glycoprotein Hormones, alpha Subunit - metabolism</subject><subject>GnIH</subject><subject>gonadotrophin mRNAs</subject><subject>Hypothalamic Hormones - physiology</subject><subject>hypothalamus</subject><subject>In Vitro Techniques</subject><subject>Luteinizing Hormone - blood</subject><subject>Male</subject><subject>Nesting Behavior - physiology</subject><subject>Ovary - metabolism</subject><subject>Pituitary Gland, Anterior - metabolism</subject><subject>reproduction</subject><subject>Reproduction - physiology</subject><subject>RNA, Messenger - analysis</subject><subject>Sex Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0953-8194</issn><issn>1365-2826</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u0zAcxyMEYmXwCsgXuCX4T-wkBw6oa7tVUxkMxNFyHJe6S-zOdkT3LHuK8SB7Jpy26sQJfLFlfz6_n-1vkgAEMxTHh3WGCKMpLjHLMIQ0gwgzmG2fJaPjwfNkBCtK0hJV-Unyyvs1hKigBL5MThBlrMgpHSX3M2tEY4Ozm5U24MKsdK2DdXfg3LrOGgXO1MYp75UHf6OPD0CYBkxt22rZqvQ66K5vRdDm59F9_A2u-7o3OoDJdldGWwOiHFYKXOnQ6yBiK7vcbZzZTvmgJRivtLxR5nXyYilar94c5tPk-3TybXyeXn6eXYw_XaYyZwymZb5kDcsRI0SSmhACSUNlQRiTNSsgI0VdQyFFyTARspFEyhJXuUCVxKwUNTlN3u_rbpy97eMVeKe9VG0rjLK956zApKI5_SeICkIQRjiC5R6Uznrv1JJvnO7iUzmCfEiQr_kQFB-C4kOCfJcg30b17aFHX3eqeRIPkUXg3QEQXop26YSR2j9xLMe4KlHkPu65X7pVd_99AT5fTIZV9NO9r31Q26Mv3E38EFJQ_mMx41-vpvl8vkD8C_kDTvvJ6w</recordid><startdate>200412</startdate><enddate>200412</enddate><creator>Ciccone, N. A.</creator><creator>Dunn, I. C.</creator><creator>Boswell, T.</creator><creator>Tsutsui, K.</creator><creator>Ubuka, T.</creator><creator>Ukena, K.</creator><creator>Sharp, P. J.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200412</creationdate><title>Gonadotrophin Inhibitory Hormone Depresses Gonadotrophin α and Follicle-Stimulating Hormone β Subunit Expression in the Pituitary of the Domestic Chicken</title><author>Ciccone, N. A. ; Dunn, I. C. ; Boswell, T. ; Tsutsui, K. ; Ubuka, T. ; Ukena, K. ; Sharp, P. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4660-84f6d641633c3b33303d5c7366cb670637bb0aca8623acdc3cc8294a19c268ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Avian Proteins - physiology</topic><topic>Biological and medical sciences</topic><topic>chicken</topic><topic>Chickens</topic><topic>Female</topic><topic>Follicle Stimulating Hormone, beta Subunit - genetics</topic><topic>Follicle Stimulating Hormone, beta Subunit - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>Glycoprotein Hormones, alpha Subunit - genetics</topic><topic>Glycoprotein Hormones, alpha Subunit - metabolism</topic><topic>GnIH</topic><topic>gonadotrophin mRNAs</topic><topic>Hypothalamic Hormones - physiology</topic><topic>hypothalamus</topic><topic>In Vitro Techniques</topic><topic>Luteinizing Hormone - blood</topic><topic>Male</topic><topic>Nesting Behavior - physiology</topic><topic>Ovary - metabolism</topic><topic>Pituitary Gland, Anterior - metabolism</topic><topic>reproduction</topic><topic>Reproduction - physiology</topic><topic>RNA, Messenger - analysis</topic><topic>Sex Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ciccone, N. A.</creatorcontrib><creatorcontrib>Dunn, I. C.</creatorcontrib><creatorcontrib>Boswell, T.</creatorcontrib><creatorcontrib>Tsutsui, K.</creatorcontrib><creatorcontrib>Ubuka, T.</creatorcontrib><creatorcontrib>Ukena, K.</creatorcontrib><creatorcontrib>Sharp, P. J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroendocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ciccone, N. A.</au><au>Dunn, I. C.</au><au>Boswell, T.</au><au>Tsutsui, K.</au><au>Ubuka, T.</au><au>Ukena, K.</au><au>Sharp, P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gonadotrophin Inhibitory Hormone Depresses Gonadotrophin α and Follicle-Stimulating Hormone β Subunit Expression in the Pituitary of the Domestic Chicken</atitle><jtitle>Journal of neuroendocrinology</jtitle><addtitle>J Neuroendocrinol</addtitle><date>2004-12</date><risdate>2004</risdate><volume>16</volume><issue>12</issue><spage>999</spage><epage>1006</epage><pages>999-1006</pages><issn>0953-8194</issn><eissn>1365-2826</eissn><abstract>Studies performed in vitro suggest that a novel 12 amino acid RF amide peptide, isolated from the quail hypothalamus, is a gonadotrophin inhibitory hormone (GnIH). The aim of the present study was to investigate this hypothesis in the domestic chicken. Injections of GnIH into nest‐deprived incubating hens failed to depress the concentration of plasma luteinizing hormone (LH). Addition of GnIH to short‐term (120 min) cultures of diced pituitary glands from adult cockerels depressed follicle‐stimulating hormone (FSH) and LH release and depressed common α and FSHβ gonadotrophin subunit mRNAs, with no effect on LHβ subunit mRNA. Hypothalamic GnIH mRNA was higher in incubating (out‐of‐lay) than in laying hens, but there was no significant difference in the amount of hypothalamic GnIH mRNA in out‐of‐lay and laying broiler breeder hens at the end of a laying year. It is concluded that avian GnIH may play a role in controlling gonadotrophin synthesis and associated constitutive release in the domestic chicken.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15667455</pmid><doi>10.1111/j.1365-2826.2005.01260.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of neuroendocrinology, 2004-12, Vol.16 (12), p.999-1006 |
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| subjects | Animals Avian Proteins - physiology Biological and medical sciences chicken Chickens Female Follicle Stimulating Hormone, beta Subunit - genetics Follicle Stimulating Hormone, beta Subunit - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation Glycoprotein Hormones, alpha Subunit - genetics Glycoprotein Hormones, alpha Subunit - metabolism GnIH gonadotrophin mRNAs Hypothalamic Hormones - physiology hypothalamus In Vitro Techniques Luteinizing Hormone - blood Male Nesting Behavior - physiology Ovary - metabolism Pituitary Gland, Anterior - metabolism reproduction Reproduction - physiology RNA, Messenger - analysis Sex Factors Vertebrates: endocrinology |
| title | Gonadotrophin Inhibitory Hormone Depresses Gonadotrophin α and Follicle-Stimulating Hormone β Subunit Expression in the Pituitary of the Domestic Chicken |
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