Risk factors for aortic valve calcification in patients on regular hemodialysis
Aortic valve calcification (AVC) accelerates development of aortic valve stenosis and cardiovascular complications. Hyperphosphatemia is one of the key risk factors for aortic valve calcification. The aim of this study was to evaluate the prevalence of AVC in patients on regular hemodialysis and to...
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| Veröffentlicht in: | International journal of artificial organs 2009-03, Vol.32 (3), p.173-179 |
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| creator | Petrovic, D Obrenovic, R Stojimirovic, B |
| description | Aortic valve calcification (AVC) accelerates development of aortic valve stenosis and cardiovascular complications. Hyperphosphatemia is one of the key risk factors for aortic valve calcification.
The aim of this study was to evaluate the prevalence of AVC in patients on regular hemodialysis and to assess the impact of different factors on its appearance.
The study investigated a total of 115 patients treated in the Hemodialysis Department of the Urology and Nephrology Clinic at the Kragujevac Clinical Center in Serbia. The variables investigated were: serum albumin, C-reactive protein (CRP), homocysteine, total cholesterol, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), Apolipoprotein A-I (Apo A-I), Apolipoprotein B (Apo B) and lipoprotein (a), calcium, phosphate and parathormone, and calcium-phosphorus product (Ca x P). Patients were evaluated by echocardiography for AVC. Statistical analysis included univariate and multivariate logistic regression analysis.
Univariate regression analysis showed that serum phosphate levels and Ca x P are the most important risk factors for AVC (p |
| doi_str_mv | 10.1177/039139880903200308 |
| format | Article |
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The aim of this study was to evaluate the prevalence of AVC in patients on regular hemodialysis and to assess the impact of different factors on its appearance.
The study investigated a total of 115 patients treated in the Hemodialysis Department of the Urology and Nephrology Clinic at the Kragujevac Clinical Center in Serbia. The variables investigated were: serum albumin, C-reactive protein (CRP), homocysteine, total cholesterol, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), Apolipoprotein A-I (Apo A-I), Apolipoprotein B (Apo B) and lipoprotein (a), calcium, phosphate and parathormone, and calcium-phosphorus product (Ca x P). Patients were evaluated by echocardiography for AVC. Statistical analysis included univariate and multivariate logistic regression analysis.
Univariate regression analysis showed that serum phosphate levels and Ca x P are the most important risk factors for AVC (p<0.001). Multivariate logistic regression analysis revealed that hyperphosphatemia is an independent risk factor for AVC (p<0.001).
Hyperphosphatemia is an independent risk factor for aortic valve calcification.</description><identifier>ISSN: 0391-3988</identifier><identifier>EISSN: 1724-6040</identifier><identifier>DOI: 10.1177/039139880903200308</identifier><identifier>PMID: 19440993</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aortic Valve - diagnostic imaging ; Biomarkers - blood ; Calcinosis - diagnostic imaging ; Calcinosis - epidemiology ; Calcinosis - etiology ; Calcium - blood ; Female ; Heart Valve Diseases - diagnostic imaging ; Heart Valve Diseases - epidemiology ; Heart Valve Diseases - etiology ; Humans ; Hyperphosphatemia - blood ; Hyperphosphatemia - complications ; Hyperphosphatemia - epidemiology ; Logistic Models ; Male ; Middle Aged ; Phosphates - blood ; Prevalence ; Renal Dialysis - adverse effects ; Risk Assessment ; Risk Factors ; Serbia - epidemiology ; Time Factors ; Ultrasonography</subject><ispartof>International journal of artificial organs, 2009-03, Vol.32 (3), p.173-179</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-6b1b6b07c5e1d339d4896991f26d4e21f35a457638f23b2abf372048bd5a48f93</citedby><cites>FETCH-LOGICAL-c332t-6b1b6b07c5e1d339d4896991f26d4e21f35a457638f23b2abf372048bd5a48f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19440993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petrovic, D</creatorcontrib><creatorcontrib>Obrenovic, R</creatorcontrib><creatorcontrib>Stojimirovic, B</creatorcontrib><title>Risk factors for aortic valve calcification in patients on regular hemodialysis</title><title>International journal of artificial organs</title><addtitle>Int J Artif Organs</addtitle><description>Aortic valve calcification (AVC) accelerates development of aortic valve stenosis and cardiovascular complications. Hyperphosphatemia is one of the key risk factors for aortic valve calcification.
The aim of this study was to evaluate the prevalence of AVC in patients on regular hemodialysis and to assess the impact of different factors on its appearance.
The study investigated a total of 115 patients treated in the Hemodialysis Department of the Urology and Nephrology Clinic at the Kragujevac Clinical Center in Serbia. The variables investigated were: serum albumin, C-reactive protein (CRP), homocysteine, total cholesterol, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), Apolipoprotein A-I (Apo A-I), Apolipoprotein B (Apo B) and lipoprotein (a), calcium, phosphate and parathormone, and calcium-phosphorus product (Ca x P). Patients were evaluated by echocardiography for AVC. Statistical analysis included univariate and multivariate logistic regression analysis.
Univariate regression analysis showed that serum phosphate levels and Ca x P are the most important risk factors for AVC (p<0.001). Multivariate logistic regression analysis revealed that hyperphosphatemia is an independent risk factor for AVC (p<0.001).
Hyperphosphatemia is an independent risk factor for aortic valve calcification.</description><subject>Adult</subject><subject>Aged</subject><subject>Aortic Valve - diagnostic imaging</subject><subject>Biomarkers - blood</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - epidemiology</subject><subject>Calcinosis - etiology</subject><subject>Calcium - blood</subject><subject>Female</subject><subject>Heart Valve Diseases - diagnostic imaging</subject><subject>Heart Valve Diseases - epidemiology</subject><subject>Heart Valve Diseases - etiology</subject><subject>Humans</subject><subject>Hyperphosphatemia - blood</subject><subject>Hyperphosphatemia - complications</subject><subject>Hyperphosphatemia - epidemiology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phosphates - blood</subject><subject>Prevalence</subject><subject>Renal Dialysis - adverse effects</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Serbia - epidemiology</subject><subject>Time Factors</subject><subject>Ultrasonography</subject><issn>0391-3988</issn><issn>1724-6040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotlb_gAvJyt3ozWPyWErxBYWC6HrIZBKNzjQ1mSn03zulBRcuXN0H3zlwDkKXBG4IkfIWmCZMKwUaGAVgoI7QlEjKCwEcjtF0BxQ7YoLOcv4EIILz8hRNiOYctGZTtHwJ-Qt7Y_uYMvYxYRNTHyzemHbjsDWtDT5Y04e4wmGF1-PmVn3G45nc-9CahD9cF5tg2m0O-RydeNNmd3GYM_T2cP86fyoWy8fn-d2isIzRvhA1qUUN0paONIzphisttCaeioY7SjwrDS-lYMpTVlNTeyYpcFU34195zWboeu-7TvF7cLmvupCta1uzcnHIlZB0DK_-ByloJoWCEaR70KaYc3K-WqfQmbStCFS7vqu_fY-iq4P7UHeu-ZUcCmY_jMB6WQ</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Petrovic, D</creator><creator>Obrenovic, R</creator><creator>Stojimirovic, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Risk factors for aortic valve calcification in patients on regular hemodialysis</title><author>Petrovic, D ; Obrenovic, R ; Stojimirovic, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-6b1b6b07c5e1d339d4896991f26d4e21f35a457638f23b2abf372048bd5a48f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aortic Valve - diagnostic imaging</topic><topic>Biomarkers - blood</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - epidemiology</topic><topic>Calcinosis - etiology</topic><topic>Calcium - blood</topic><topic>Female</topic><topic>Heart Valve Diseases - diagnostic imaging</topic><topic>Heart Valve Diseases - epidemiology</topic><topic>Heart Valve Diseases - etiology</topic><topic>Humans</topic><topic>Hyperphosphatemia - blood</topic><topic>Hyperphosphatemia - complications</topic><topic>Hyperphosphatemia - epidemiology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phosphates - blood</topic><topic>Prevalence</topic><topic>Renal Dialysis - adverse effects</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Serbia - epidemiology</topic><topic>Time Factors</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrovic, D</creatorcontrib><creatorcontrib>Obrenovic, R</creatorcontrib><creatorcontrib>Stojimirovic, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrovic, D</au><au>Obrenovic, R</au><au>Stojimirovic, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for aortic valve calcification in patients on regular hemodialysis</atitle><jtitle>International journal of artificial organs</jtitle><addtitle>Int J Artif Organs</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>32</volume><issue>3</issue><spage>173</spage><epage>179</epage><pages>173-179</pages><issn>0391-3988</issn><eissn>1724-6040</eissn><abstract>Aortic valve calcification (AVC) accelerates development of aortic valve stenosis and cardiovascular complications. Hyperphosphatemia is one of the key risk factors for aortic valve calcification.
The aim of this study was to evaluate the prevalence of AVC in patients on regular hemodialysis and to assess the impact of different factors on its appearance.
The study investigated a total of 115 patients treated in the Hemodialysis Department of the Urology and Nephrology Clinic at the Kragujevac Clinical Center in Serbia. The variables investigated were: serum albumin, C-reactive protein (CRP), homocysteine, total cholesterol, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), Apolipoprotein A-I (Apo A-I), Apolipoprotein B (Apo B) and lipoprotein (a), calcium, phosphate and parathormone, and calcium-phosphorus product (Ca x P). Patients were evaluated by echocardiography for AVC. Statistical analysis included univariate and multivariate logistic regression analysis.
Univariate regression analysis showed that serum phosphate levels and Ca x P are the most important risk factors for AVC (p<0.001). Multivariate logistic regression analysis revealed that hyperphosphatemia is an independent risk factor for AVC (p<0.001).
Hyperphosphatemia is an independent risk factor for aortic valve calcification.</abstract><cop>United States</cop><pmid>19440993</pmid><doi>10.1177/039139880903200308</doi><tpages>7</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Adult Aged Aortic Valve - diagnostic imaging Biomarkers - blood Calcinosis - diagnostic imaging Calcinosis - epidemiology Calcinosis - etiology Calcium - blood Female Heart Valve Diseases - diagnostic imaging Heart Valve Diseases - epidemiology Heart Valve Diseases - etiology Humans Hyperphosphatemia - blood Hyperphosphatemia - complications Hyperphosphatemia - epidemiology Logistic Models Male Middle Aged Phosphates - blood Prevalence Renal Dialysis - adverse effects Risk Assessment Risk Factors Serbia - epidemiology Time Factors Ultrasonography |
| title | Risk factors for aortic valve calcification in patients on regular hemodialysis |
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