Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability

The thiazolidinediones (TZDs) rosiglitazone and pioglitazone are newer additions to the antidiabetic armamentarium and are indicated for the treatment of type 2 diabetes mellitus (T2DM) in the United States. The TZDs are peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists that pro...

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Veröffentlicht in:	Diabetes technology & therapeutics 2004-12, Vol.6 (6), p.850-863
Hauptverfasser:	Vasudevan, Abu R, Balasubramanyam, Ashok
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose - drug effects Blood Glucose - metabolism Diabetes Mellitus, Type 2 - drug therapy Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Lipids - blood PPAR gamma - agonists Thiazolidinediones - pharmacology Thiazolidinediones - therapeutic use
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