Molecular genetic alterations in endometrioid carcinomas of the ovary: Similar frequency of beta-catenin abnormalities but lower rate of microsatellite instability and PTEN alterations than in uterine endometrioid carcinomas

Endometrioid carcinomas of the ovary closely resemble their uterine counterparts. It has been suggested that the former tumors have the same molecular alterations (microsatellite instability [MSI], PTEN, and beta-catenin) described in endometrioid carcinomas of the uterus. We analyzed 55 ovarian car...

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Veröffentlicht in:	Human pathology 2004-11, Vol.35 (11), p.1360-1368
Hauptverfasser:	Catasús, Lluis, Bussaglia, Elena, Rodrı́guez, Ingrid, Gallardo, Alberto, Pons, Cristina, Irving, Julie A., Prat, Jaime
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Base Sequence beta Catenin Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Carcinoma, Endometrioid - genetics Carcinoma, Endometrioid - mortality Carcinoma, Endometrioid - pathology Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism DNA Mutational Analysis endometrioid carcinoma Female Female genital diseases Genomic Instability Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Loss of Heterozygosity Medical sciences microsatellite instability Microsatellite Repeats - genetics Middle Aged Molecular Sequence Data Mutation Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Proteins PTEN PTEN Phosphohydrolase Survival Rate Trans-Activators - genetics Trans-Activators - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Uterine Neoplasms - genetics Uterine Neoplasms - mortality Uterine Neoplasms - pathology
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