Immune regulation by 4-1BB and 4-1BBL: complexities and challenges

The tumor necrosis factor receptor family member 4-1BB plays a key role in the survival of activated and memory CD8⁺ T cells. Depending on the disease model, 4-1BB can participate at different stages and influence different aspects of the immune response, likely due to the differential expression of...

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Veröffentlicht in:	Immunological reviews 2009-05, Vol.229 (1), p.192-215
Hauptverfasser:	Wang, Chao, Lin, Gloria H.Y, McPherson, Ann J, Watts, Tania H
Format:	Artikel
Sprache:	eng
Schlagworte:	4-1BB Ligand - genetics 4-1BB Ligand - immunology 4-1BB Ligand - metabolism agonistic antibody therapy Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism bidirectional signaling costimulation Cytokines - immunology Cytokines - metabolism Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Humans Immunologic Memory Infection - immunology regulatory T cells Signal Transduction - immunology T-cell memory T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumor Necrosis Factor Ligand Superfamily Member 14 - immunology Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - immunology Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism
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