Calcineurin inhibitor-free GVHD prophylaxis with sirolimus, mycophenolate mofetil and ATG in Allo-SCT for leukemia patients with high relapse risk: an observational cohort study

Certain leukemias have a high relapse risk even after allo-SCT, and GVHD prophylaxis with calcineurin inhibitors (CNIs) may interfere with a possible GVL effect. Therefore, we replaced CYA by sirolimus in patients with high relapse risk. In contrast to CNIs, sirolimus promotes the generation of regu...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2009-05, Vol.43 (9), p.717-723
Hauptverfasser:	Schleuning, M, Judith, D, Jedlickova, Z, Stübig, T, Heshmat, M, Baurmann, H, Schwerdtfeger, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute myeloid leukemia Adult Biological and medical sciences Blast crisis Calcineurin Calcineurin Inhibitors Care and treatment Cell Biology Cohort analysis Cohort Studies Complications and side effects Disease prevention Dosage and administration Female Flt3 protein Graft versus host reaction Graft vs Host Disease - drug therapy Graft vs Host Disease - prevention & control Health aspects Hematologic and hematopoietic diseases Hematology Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Humans Immunomodulators Immunosuppressive Agents - administration & dosage Internal Medicine Kinases Leukemia Leukemia - complications Leukemia - mortality Leukemia - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes T Male Medical sciences Medicine Medicine & Public Health Middle Aged Mycophenolate mofetil Mycophenolic acid Mycophenolic Acid - administration & dosage Mycophenolic Acid - analogs & derivatives Observational studies original-article Patient outcomes Pharmacology. Drug treatments Premedication - methods Prevention Prognosis Prophylaxis Protein-tyrosine kinase Public Health Rapamycin Remission Reproduction (copying) Risk Risk factors Salvage Therapy - methods Sirolimus - administration & dosage Stem cell transplantation Stem Cells Survival Rate Thrombotic microangiopathy Transplantation Transplantation, Homologous Tyrosine Young Adult
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