Artemin is oncogenic for human mammary carcinoma cells

We report that artemin, a member of the glial cell line-derived neurotrophic factor family of ligands, is oncogenic for human mammary carcinoma. Artemin is expressed in numerous human mammary carcinoma cell lines. Forced expression of artemin in mammary carcinoma cells results in increased anchorage...

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Veröffentlicht in:	Oncogene 2009-05, Vol.28 (19), p.2034-2045
Hauptverfasser:	Kang, J, Perry, J K, Pandey, V, Fielder, G C, Mei, B, Qian, P X, Wu, Z S, Zhu, T, Liu, D X, Lobie, P E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - metabolism Cancer Carcinoma Care and treatment Cell Biology Cell Line, Tumor Cell migration Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Chemotherapy Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Glial cell line-derived neurotrophic factor Glial cells Health aspects Human Genetics Humans Internal Medicine Invasiveness Mammary gland Medicine Medicine & Public Health Metastases Mice Mice, Nude Molecular and cellular biology Molecular biology Neoplasm Invasiveness Neoplasm Transplantation Nerve Tissue Proteins - metabolism Neuronal-glial interactions Neurons Neurotrophic functions Oncology original-article Phenotypes Proteins siRNA Transplantation, Heterologous Tumor cell lines Tumors Xenografts
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