KGF-induced motility of breast cancer cells is dependent on Grb2 and Erk1,2

Breast cancer metastasis is directly associated with breast cancer cell motility. Using a cell culture wounding model, we have demonstrated that keratinocyte growth factor (KGF) enhanced the motility of estrogen receptor-positive breast cancer cells. However, the mechanisms by which KGF enhanced mot...

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Veröffentlicht in:	Clinical & experimental metastasis 2004-01, Vol.21 (5), p.437-443
Hauptverfasser:	Zang, Xiao-Ping, Siwak, Doris R, Nguyen, Thi X, Tari, Ana M, Pento, J Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Antifungal Agents - pharmacology Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Movement - drug effects Down-Regulation Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Female Fibroblast Growth Factor 7 Fibroblast Growth Factors - pharmacology Genistein - pharmacology GRB2 Adaptor Protein Humans Keratinocytes - drug effects Keratinocytes - metabolism Lovastatin - analogs & derivatives Lovastatin - pharmacology Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Cells, Cultured
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