Inhibition of caspase-3 blocks long-term potentiation in hippocampal slices
Incubation of rat hippocampal slices with the specific caspase-3 inhibitor Z-DEVD-FMK led to suppression of long-term potentiation (LTP), which developed over a period of time. Incubation of Z-DEVD-FMK for 4 h and more prevented tetanization from evoking LTP; Z-DEVD-FMK had no effect on baseline mea...
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| Veröffentlicht in: | Neuroscience and behavioral physiology 2004-11, Vol.34 (9), p.877-880 |
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| container_title | Neuroscience and behavioral physiology |
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| creator | Kudryashov, I E Yakovlev, A A Kudryashova, I V Gulyaeva, N V |
| description | Incubation of rat hippocampal slices with the specific caspase-3 inhibitor Z-DEVD-FMK led to suppression of long-term potentiation (LTP), which developed over a period of time. Incubation of Z-DEVD-FMK for 4 h and more prevented tetanization from evoking LTP; Z-DEVD-FMK had no effect on baseline measures of synaptic plasticity and short-term plasticity (population spike amplitude, level of facilitation in conditions of paired stimuli). These data provide the first evidence for the involvement of a mechanism mediated by caspase-3 in the phenomenon of LTP. |
| doi_str_mv | 10.1023/B:NEAB.0000042571.86110.28 |
| format | Article |
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| subjects | Analysis of Variance Animals Caspase 3 Caspase Inhibitors Caspases - physiology Electric Stimulation - methods Hippocampus - drug effects Hippocampus - physiology Hippocampus - radiation effects In Vitro Techniques Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Long-Term Potentiation - radiation effects Oligopeptides - pharmacology Rats Rats, Wistar Regression Analysis Time Factors |
| title | Inhibition of caspase-3 blocks long-term potentiation in hippocampal slices |
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