The brain entry of risperidone and 9-hydroxyrisperidone is greatly limited by P-glycoprotein

P-glycoprotein (P-gp) in the brain capillary endothelial cell limits the entry of many drugs into the brain. Our previous in-vitro study using ATPase as a marker of P-gp activity suggested that risperidone might be effectively transported by P-gp. In the present study, we compared the concentrations...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2004-12, Vol.7 (4), p.415-419
Hauptverfasser:	Wang, Jun-Sheng, Ruan, Ying, Taylor, Robin M., Donovan, Jennifer L., Markowitz, John S., DeVane, C. Lindsay
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Brain - metabolism Chromatography, High Pressure Liquid Injections, Intraperitoneal Isoxazoles - pharmacokinetics Male Mice Mice, Transgenic Paliperidone Palmitate Pyrimidines - pharmacokinetics Risperidone - pharmacokinetics Serotonin Antagonists - pharmacokinetics Tissue Distribution
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