Fibrinogen stimulates in vitro angiogenesis by choroidal endothelial cells via autocrine VEGF

The purpose of this study is to investigate the effect of fibrinogen on angiogenesis in vitro formed by cultured bovine choroidal endothelial cells (BCECs) and the involvement of vascular endothelial growth factor (VEGF) in this mechanism. For in vitro tube formation assay, BCECs were seeded on coll...

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Veröffentlicht in:	Graefe's archive for clinical and experimental ophthalmology 2004-09, Vol.242 (9), p.777-783
Hauptverfasser:	Shiose, Satomi, Hata, Yasuaki, Noda, Yoshihiro, Sassa, Yukio, Takeda, Atsunobu, Yoshikawa, Hiroshi, Fujisawa, Kimihiko, Kubota, Toshiaki, Ishibashi, Tatsuro
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Blotting, Northern Blotting, Western Cattle Cells, Cultured Choroid - blood supply Choroidal Neovascularization - etiology Choroidal Neovascularization - metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Fibrinogen - pharmacology Gene Expression Hypoxia-Inducible Factor 1, alpha Subunit Indoles - pharmacology Ophthalmology Protein-Tyrosine Kinases - antagonists & inhibitors Pyrroles - pharmacology RNA, Messenger - metabolism Transcription Factors - metabolism Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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