Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils

Amyloid fibrils are ordered polymers in which constituent polypeptides adopt a non-native fold. Despite their importance in degenerative human diseases, the overall structure of amyloid fibrils remains unknown. High-resolution studies of model peptide assemblies have identified residues forming cros...

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Veröffentlicht in:	Journal of molecular biology 2009-05, Vol.389 (1), p.48-57
Hauptverfasser:	White, Helen E, Hodgkinson, Julie L, Jahn, Thomas R, Cohen-Krausz, Sara, Gosal, Walraj S, Müller, Shirley, Orlova, Elena V, Radford, Sheena E, Saibil, Helen R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - chemistry beta 2-Microglobulin - chemistry beta 2-Microglobulin - metabolism beta 2-Microglobulin - ultrastructure Models, Molecular Protein Structure, Quaternary Protein Structure, Secondary Protein Subunits - chemistry
Online-Zugang:	Volltext
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