Aspartic acid scaffold in bradykinin B1 antagonists

Several novel bradykinin B1 receptor (B1R) antagonists were synthesized utilizing a new aspartic acid scaffold. This core is derived from the highly potent dihydroquinoxalinone scaffold published recently by researchers at Merck (Ha et al. Biochem. Biophys. Res. Commun. 2005, 331, 159–166). Despite...

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Veröffentlicht in:	Journal of peptide science 2009-06, Vol.15 (6), p.423-434
Hauptverfasser:	Huszár, József, Timár, Zoltán, Bogár, Ferenc, Penke, Botond, Kiss, Róbert, Szalai, Krisztina Katalin, Schmidt, Éva, Papp, Andrea, Keserű, György
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aspartic Acid - analogs & derivatives Aspartic Acid - chemistry B1 antagonists binding modes bradykinin Bradykinin B1 Receptor Antagonists Computer Simulation docking Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Molecular Structure peptidomimetic Protein Structure, Secondary Sequence Homology, Amino Acid
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