Aperistaltic effect of hyoscine N-butylbromide versus glucagon on the small bowel assessed by magnetic resonance imaging
The aim of this prospective study was to compare the intraindividual aperistaltic effect of 40 mg hyoscine N -butylbromide (HBB/Buscopan) with that of 1 mg glucagon on small bowel motility by using magnetic resonance imaging (MRI). Ten healthy volunteers underwent two separate 1.5-T MRI studies (HBB...
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| Veröffentlicht in: | European radiology 2009-06, Vol.19 (6), p.1387-1393 |
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| creator | Froehlich, Johannes M. Daenzer, Muriel von Weymarn, Constantin Erturk, S. Mehmet Zollikofer, Christoph L. Patak, Michael A. |
| description | The aim of this prospective study was to compare the intraindividual aperistaltic effect of 40 mg hyoscine
N
-butylbromide (HBB/Buscopan) with that of 1 mg glucagon on small bowel motility by using magnetic resonance imaging (MRI). Ten healthy volunteers underwent two separate 1.5-T MRI studies (HBB/glucagon) after a standardized oral preparation with an aqueous solution of Gd-DOTA and ispaghula (Metamucil). A 2D T1-w GRE sequence was acquired (TR 2.7 ms/TE 1.3 ms, temporal resolution 0.25 s) before and after intravenous (i.v.) drug administration and motility was followed over 1 h. On the resulting images the cross-sectional luminal diameters were assessed and plotted over time. Baseline motility frequency, onset of aperistalsis, duration of arrest, reappearance of motility and return to normal motility were analysed. Significant differences regarding reliability and duration of aperistalsis were observed. In the HBB group aperistalsis lasted a mean of 6.8 ± 5.3 min compared with 18.3 ± 7 min after glucagon (
p
|
| doi_str_mv | 10.1007/s00330-008-1293-2 |
| format | Article |
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N
-butylbromide (HBB/Buscopan) with that of 1 mg glucagon on small bowel motility by using magnetic resonance imaging (MRI). Ten healthy volunteers underwent two separate 1.5-T MRI studies (HBB/glucagon) after a standardized oral preparation with an aqueous solution of Gd-DOTA and ispaghula (Metamucil). A 2D T1-w GRE sequence was acquired (TR 2.7 ms/TE 1.3 ms, temporal resolution 0.25 s) before and after intravenous (i.v.) drug administration and motility was followed over 1 h. On the resulting images the cross-sectional luminal diameters were assessed and plotted over time. Baseline motility frequency, onset of aperistalsis, duration of arrest, reappearance of motility and return to normal motility were analysed. Significant differences regarding reliability and duration of aperistalsis were observed. In the HBB group aperistalsis lasted a mean of 6.8 ± 5.3 min compared with 18.3 ± 7 min after glucagon (
p
< 0.0001). In 50% of cases HBB did not accomplish aperistalsis, whereas glucagon always succeeded (
p
= 0.05). There were no significant differences in terms of baseline and end frequencies for the onset of aperistalsis (22.2 ± 37.5 s HBB/13.4 ± 9.2 s glucagon,
p
= 0.1), nor for the return to normal motility. Arrest of small bowel motion is achieved more reliably and lasts significantly longer after i.v. administration of 1 mg glucagon compared with 40 mg HBB.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-008-1293-2</identifier><identifier>PMID: 19190916</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject><![CDATA[Adult ; Butylscopolammonium Bromide - administration & dosage ; Contrast Media - administration & dosage ; Diagnostic Radiology ; Female ; Gastrointestinal ; Glucagon - administration & dosage ; Humans ; Image Enhancement - methods ; Imaging ; Internal Medicine ; Interventional Radiology ; Intestine, Small - anatomy & histology ; Intestine, Small - drug effects ; Intestine, Small - physiology ; Magnetic Resonance Imaging - methods ; Male ; Medicine ; Medicine & Public Health ; Neuroradiology ; Parasympatholytics - administration & dosage ; Peristalsis - drug effects ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Ultrasound]]></subject><ispartof>European radiology, 2009-06, Vol.19 (6), p.1387-1393</ispartof><rights>European Society of Radiology 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-9d1ee09cf6bfc70b3a4e1ef687ac831be462e76aced5bbbfcc2b413fcc6a5c843</citedby><cites>FETCH-LOGICAL-c478t-9d1ee09cf6bfc70b3a4e1ef687ac831be462e76aced5bbbfcc2b413fcc6a5c843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-008-1293-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-008-1293-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19190916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Froehlich, Johannes M.</creatorcontrib><creatorcontrib>Daenzer, Muriel</creatorcontrib><creatorcontrib>von Weymarn, Constantin</creatorcontrib><creatorcontrib>Erturk, S. Mehmet</creatorcontrib><creatorcontrib>Zollikofer, Christoph L.</creatorcontrib><creatorcontrib>Patak, Michael A.</creatorcontrib><title>Aperistaltic effect of hyoscine N-butylbromide versus glucagon on the small bowel assessed by magnetic resonance imaging</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>The aim of this prospective study was to compare the intraindividual aperistaltic effect of 40 mg hyoscine
N
-butylbromide (HBB/Buscopan) with that of 1 mg glucagon on small bowel motility by using magnetic resonance imaging (MRI). Ten healthy volunteers underwent two separate 1.5-T MRI studies (HBB/glucagon) after a standardized oral preparation with an aqueous solution of Gd-DOTA and ispaghula (Metamucil). A 2D T1-w GRE sequence was acquired (TR 2.7 ms/TE 1.3 ms, temporal resolution 0.25 s) before and after intravenous (i.v.) drug administration and motility was followed over 1 h. On the resulting images the cross-sectional luminal diameters were assessed and plotted over time. Baseline motility frequency, onset of aperistalsis, duration of arrest, reappearance of motility and return to normal motility were analysed. Significant differences regarding reliability and duration of aperistalsis were observed. In the HBB group aperistalsis lasted a mean of 6.8 ± 5.3 min compared with 18.3 ± 7 min after glucagon (
p
< 0.0001). In 50% of cases HBB did not accomplish aperistalsis, whereas glucagon always succeeded (
p
= 0.05). There were no significant differences in terms of baseline and end frequencies for the onset of aperistalsis (22.2 ± 37.5 s HBB/13.4 ± 9.2 s glucagon,
p
= 0.1), nor for the return to normal motility. Arrest of small bowel motion is achieved more reliably and lasts significantly longer after i.v. administration of 1 mg glucagon compared with 40 mg HBB.</description><subject>Adult</subject><subject>Butylscopolammonium Bromide - administration & dosage</subject><subject>Contrast Media - administration & dosage</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Gastrointestinal</subject><subject>Glucagon - administration & dosage</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Intestine, Small - anatomy & histology</subject><subject>Intestine, Small - drug effects</subject><subject>Intestine, Small - physiology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuroradiology</subject><subject>Parasympatholytics - administration & dosage</subject><subject>Peristalsis - drug effects</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasound</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU2LFDEQhoMo7uzqD_AiwYO3aL6m0zkuy6oLi170HJJ0dW8v3cmY6lbn35tmBhYEoaBC8tSbhIeQN4J_EJybj8i5Upxx3jIhrWLyGdkJrSQTvNXPyY5b1TJjrb4gl4iPnHMrtHlJLoQVtq6bHflzfYAy4uKnZYwU-h7iQnNPH44Z45iAfmVhXY5TKHkeO6C_oOCKdJjW6IecaK3lASjOfppoyL9hoh4RanU0HOnshwRbcgHMyacIdKx7YxpekRe9nxBen_sV-fHp9vvNF3b_7fPdzfU9i9q0C7OdAOA29k3oo-FBeQ0C-qY1PrZKBNCNBNP4CN0-hMpEGbRQtTd-H1utrsj7U-6h5J8r4OLmESNMk0-QV3SNkUrspazgu3_Ax7yWVN_mpGitNkpvkDhBsWTEAr07lPqhcnSCu82JOzlx1YnbnLht5u05eA0zdE8TZwkVkCcA61EaoDzd_P_Uv4jWmjw</recordid><startdate>20090601</startdate><enddate>20090601</enddate><creator>Froehlich, Johannes M.</creator><creator>Daenzer, Muriel</creator><creator>von Weymarn, Constantin</creator><creator>Erturk, S. Mehmet</creator><creator>Zollikofer, Christoph L.</creator><creator>Patak, Michael A.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20090601</creationdate><title>Aperistaltic effect of hyoscine N-butylbromide versus glucagon on the small bowel assessed by magnetic resonance imaging</title><author>Froehlich, Johannes M. ; Daenzer, Muriel ; von Weymarn, Constantin ; Erturk, S. Mehmet ; Zollikofer, Christoph L. ; Patak, Michael A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-9d1ee09cf6bfc70b3a4e1ef687ac831be462e76aced5bbbfcc2b413fcc6a5c843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Butylscopolammonium Bromide - administration & dosage</topic><topic>Contrast Media - administration & dosage</topic><topic>Diagnostic Radiology</topic><topic>Female</topic><topic>Gastrointestinal</topic><topic>Glucagon - administration & dosage</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Intestine, Small - anatomy & histology</topic><topic>Intestine, Small - drug effects</topic><topic>Intestine, Small - physiology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuroradiology</topic><topic>Parasympatholytics - administration & dosage</topic><topic>Peristalsis - drug effects</topic><topic>Radiology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Froehlich, Johannes M.</creatorcontrib><creatorcontrib>Daenzer, Muriel</creatorcontrib><creatorcontrib>von Weymarn, Constantin</creatorcontrib><creatorcontrib>Erturk, S. Mehmet</creatorcontrib><creatorcontrib>Zollikofer, Christoph L.</creatorcontrib><creatorcontrib>Patak, Michael A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Froehlich, Johannes M.</au><au>Daenzer, Muriel</au><au>von Weymarn, Constantin</au><au>Erturk, S. Mehmet</au><au>Zollikofer, Christoph L.</au><au>Patak, Michael A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aperistaltic effect of hyoscine N-butylbromide versus glucagon on the small bowel assessed by magnetic resonance imaging</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2009-06-01</date><risdate>2009</risdate><volume>19</volume><issue>6</issue><spage>1387</spage><epage>1393</epage><pages>1387-1393</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>The aim of this prospective study was to compare the intraindividual aperistaltic effect of 40 mg hyoscine
N
-butylbromide (HBB/Buscopan) with that of 1 mg glucagon on small bowel motility by using magnetic resonance imaging (MRI). Ten healthy volunteers underwent two separate 1.5-T MRI studies (HBB/glucagon) after a standardized oral preparation with an aqueous solution of Gd-DOTA and ispaghula (Metamucil). A 2D T1-w GRE sequence was acquired (TR 2.7 ms/TE 1.3 ms, temporal resolution 0.25 s) before and after intravenous (i.v.) drug administration and motility was followed over 1 h. On the resulting images the cross-sectional luminal diameters were assessed and plotted over time. Baseline motility frequency, onset of aperistalsis, duration of arrest, reappearance of motility and return to normal motility were analysed. Significant differences regarding reliability and duration of aperistalsis were observed. In the HBB group aperistalsis lasted a mean of 6.8 ± 5.3 min compared with 18.3 ± 7 min after glucagon (
p
< 0.0001). In 50% of cases HBB did not accomplish aperistalsis, whereas glucagon always succeeded (
p
= 0.05). There were no significant differences in terms of baseline and end frequencies for the onset of aperistalsis (22.2 ± 37.5 s HBB/13.4 ± 9.2 s glucagon,
p
= 0.1), nor for the return to normal motility. Arrest of small bowel motion is achieved more reliably and lasts significantly longer after i.v. administration of 1 mg glucagon compared with 40 mg HBB.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19190916</pmid><doi>10.1007/s00330-008-1293-2</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2009-06, Vol.19 (6), p.1387-1393 |
| issn | 0938-7994 1432-1084 |
| language | eng |
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| source | MEDLINE; Springer journals |
| subjects | Adult Butylscopolammonium Bromide - administration & dosage Contrast Media - administration & dosage Diagnostic Radiology Female Gastrointestinal Glucagon - administration & dosage Humans Image Enhancement - methods Imaging Internal Medicine Interventional Radiology Intestine, Small - anatomy & histology Intestine, Small - drug effects Intestine, Small - physiology Magnetic Resonance Imaging - methods Male Medicine Medicine & Public Health Neuroradiology Parasympatholytics - administration & dosage Peristalsis - drug effects Radiology Reproducibility of Results Sensitivity and Specificity Ultrasound |
| title | Aperistaltic effect of hyoscine N-butylbromide versus glucagon on the small bowel assessed by magnetic resonance imaging |
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