Long-Term Small Molecule and Protein Elution from TiO2 Nanotubes
In this study, TiO2 nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanot...
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| Veröffentlicht in: | Nano letters 2009-05, Vol.9 (5), p.1932-1936 |
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| container_end_page | 1936 |
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| container_issue | 5 |
| container_start_page | 1932 |
| container_title | Nano letters |
| container_volume | 9 |
| creator | Peng, Lily Mendelsohn, Adam D LaTempa, Thomas J Yoriya, Sorachon Grimes, Craig A Desai, Tejal A |
| description | In this study, TiO2 nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO2 nanotubes may be a promising candidate for a drug-eluting implant coating. |
| doi_str_mv | 10.1021/nl9001052 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1530-6984 |
| ispartof | Nano letters, 2009-05, Vol.9 (5), p.1932-1936 |
| issn | 1530-6984 1530-6992 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67231089 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Antineoplastic Agents - chemistry Cell Line Cell Proliferation Drug Implants - chemistry Mice Nanotubes - chemistry Paclitaxel - chemistry Pharmaceutical Preparations - chemistry Proteins - chemistry Serum Albumin, Bovine - chemistry Sirolimus - chemistry Titanium - chemistry |
| title | Long-Term Small Molecule and Protein Elution from TiO2 Nanotubes |
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