Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats
The metabolic changes in hippocampus, temporal cortex and prefrontal cortex in SD rats along with aging were explored using a metabonomic approach, which based on high resolution “magic angle spinning” 1H NMR spectroscopy. The metabolite profiles were analyzed by partial least squares-discriminant a...
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| Veröffentlicht in: | Neurochemistry international 2009-07, Vol.54 (8), p.481-487 |
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| creator | Zhang, Xianrong Liu, Huilang Wu, Junfang Zhang, Xu Liu, Maili Wang, Yong |
| description | The metabolic changes in hippocampus, temporal cortex and prefrontal cortex in SD rats along with aging were explored using a metabonomic approach, which based on high resolution “magic angle spinning”
1H NMR spectroscopy. The metabolite profiles were analyzed by partial least squares-discriminant analysis, and the results showed that the metabolites of the above three brain regions in old rats were dramatically different from that in the adult and young rats. The old rats showed increased myo-inositol and lactate in all of the three brain regions, and decreased N-acetylaspartate in temporal and frontal cortex, Glutamate–GABA level became imbalance in temporal cortex of old rats. In addition, compared with the adult female rats, male rats had higher levels of N-acetylaspartate, taurine, and creatine in temporal or frontal cortex. The age-related metabolic changes may indicate the early functional alterations of neural cells in these brain regions, especially the temporal cortex. The gender-related metabolic changes suggest the significance of the hormonal regulation in brain metabolism. Our work highlights the potential of metabolic profiling to enhance our understanding of biological mechanisms of brain aging. |
| doi_str_mv | 10.1016/j.neuint.2009.02.004 |
| format | Article |
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1H NMR spectroscopy. The metabolite profiles were analyzed by partial least squares-discriminant analysis, and the results showed that the metabolites of the above three brain regions in old rats were dramatically different from that in the adult and young rats. The old rats showed increased myo-inositol and lactate in all of the three brain regions, and decreased N-acetylaspartate in temporal and frontal cortex, Glutamate–GABA level became imbalance in temporal cortex of old rats. In addition, compared with the adult female rats, male rats had higher levels of N-acetylaspartate, taurine, and creatine in temporal or frontal cortex. The age-related metabolic changes may indicate the early functional alterations of neural cells in these brain regions, especially the temporal cortex. The gender-related metabolic changes suggest the significance of the hormonal regulation in brain metabolism. Our work highlights the potential of metabolic profiling to enhance our understanding of biological mechanisms of brain aging.</description><identifier>ISSN: 0197-0186</identifier><identifier>EISSN: 1872-9754</identifier><identifier>DOI: 10.1016/j.neuint.2009.02.004</identifier><identifier>PMID: 19428792</identifier><identifier>CODEN: NEUIDS</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Age ; Aging - metabolism ; Amino Acids - metabolism ; Animals ; Biological and medical sciences ; Brain Chemistry ; Female ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus - growth & development ; Hippocampus - metabolism ; Least-Squares Analysis ; Magnetic Resonance Spectroscopy ; Male ; Memory - physiology ; Metabolomics ; Metabonomic ; Multivariate Analysis ; NMR ; Partial least squares-discriminant analysis ; Prefrontal cortex ; Prefrontal Cortex - growth & development ; Prefrontal Cortex - metabolism ; Rats ; Rats, Sprague-Dawley ; Sex Characteristics ; Temporal cortex ; Temporal Lobe - growth & development ; Temporal Lobe - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Neurochemistry international, 2009-07, Vol.54 (8), p.481-487</ispartof><rights>2009 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-1b9f426f23e113658009753fc3499cb871f9806dcc3aad75138dcd7684cf9a9c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S019701860900059X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21464672$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19428792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xianrong</creatorcontrib><creatorcontrib>Liu, Huilang</creatorcontrib><creatorcontrib>Wu, Junfang</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Liu, Maili</creatorcontrib><creatorcontrib>Wang, Yong</creatorcontrib><title>Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats</title><title>Neurochemistry international</title><addtitle>Neurochem Int</addtitle><description>The metabolic changes in hippocampus, temporal cortex and prefrontal cortex in SD rats along with aging were explored using a metabonomic approach, which based on high resolution “magic angle spinning”
1H NMR spectroscopy. The metabolite profiles were analyzed by partial least squares-discriminant analysis, and the results showed that the metabolites of the above three brain regions in old rats were dramatically different from that in the adult and young rats. The old rats showed increased myo-inositol and lactate in all of the three brain regions, and decreased N-acetylaspartate in temporal and frontal cortex, Glutamate–GABA level became imbalance in temporal cortex of old rats. In addition, compared with the adult female rats, male rats had higher levels of N-acetylaspartate, taurine, and creatine in temporal or frontal cortex. The age-related metabolic changes may indicate the early functional alterations of neural cells in these brain regions, especially the temporal cortex. The gender-related metabolic changes suggest the significance of the hormonal regulation in brain metabolism. Our work highlights the potential of metabolic profiling to enhance our understanding of biological mechanisms of brain aging.</description><subject>Age</subject><subject>Aging - metabolism</subject><subject>Amino Acids - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus - growth & development</subject><subject>Hippocampus - metabolism</subject><subject>Least-Squares Analysis</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Metabolomics</subject><subject>Metabonomic</subject><subject>Multivariate Analysis</subject><subject>NMR</subject><subject>Partial least squares-discriminant analysis</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - growth & development</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sex Characteristics</subject><subject>Temporal cortex</subject><subject>Temporal Lobe - growth & development</subject><subject>Temporal Lobe - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0197-0186</issn><issn>1872-9754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvhH6AqFziRYDuOHV8qVVU_kIq4gDha3smEepXYqe3w8e_xsit6g9NopOd9NfMQ8prRhlEm3-8aj6vzueGU6obyhlLxhGxYr3itVSeekg1lWtWU9fKEvEhpRylVmnbPyQnTgvdK8w35-hGz3QYfZgeVnTJGm13wqXK-unfLEsDOy5reVRnnJUQ7VdYP1RJxjMHnskKIGX9WP1y-r-w33OdKRXpJno12SvjqOE_Jl-urz5e39d2nmw-XF3c1CM5yzbZ6FFyOvEXGWtn15RfVtSO0QmvY9oqNuqdyAGitHVTH2n6AQclewKithvaUvD30LjE8rJiymV0CnCbrMazJSMW5For_FywWpe6YKqA4gBBDSuVRs0Q32_jLMGr25s3OHMzvM9pQbor5Ejs79q_bGYfH0FF1Ad4cAZvATmO0Hlz6y3EmpJB_Dj0_cFi0fXcYTQKHHnBwESGbIbh_X_IbLwej6g</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Zhang, Xianrong</creator><creator>Liu, Huilang</creator><creator>Wu, Junfang</creator><creator>Zhang, Xu</creator><creator>Liu, Maili</creator><creator>Wang, Yong</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats</title><author>Zhang, Xianrong ; Liu, Huilang ; Wu, Junfang ; Zhang, Xu ; Liu, Maili ; Wang, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-1b9f426f23e113658009753fc3499cb871f9806dcc3aad75138dcd7684cf9a9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Age</topic><topic>Aging - metabolism</topic><topic>Amino Acids - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus</topic><topic>Hippocampus - growth & development</topic><topic>Hippocampus - metabolism</topic><topic>Least-Squares Analysis</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Metabolomics</topic><topic>Metabonomic</topic><topic>Multivariate Analysis</topic><topic>NMR</topic><topic>Partial least squares-discriminant analysis</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - growth & development</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sex Characteristics</topic><topic>Temporal cortex</topic><topic>Temporal Lobe - growth & development</topic><topic>Temporal Lobe - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xianrong</creatorcontrib><creatorcontrib>Liu, Huilang</creatorcontrib><creatorcontrib>Wu, Junfang</creatorcontrib><creatorcontrib>Zhang, Xu</creatorcontrib><creatorcontrib>Liu, Maili</creatorcontrib><creatorcontrib>Wang, Yong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemistry international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xianrong</au><au>Liu, Huilang</au><au>Wu, Junfang</au><au>Zhang, Xu</au><au>Liu, Maili</au><au>Wang, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats</atitle><jtitle>Neurochemistry international</jtitle><addtitle>Neurochem Int</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>54</volume><issue>8</issue><spage>481</spage><epage>487</epage><pages>481-487</pages><issn>0197-0186</issn><eissn>1872-9754</eissn><coden>NEUIDS</coden><abstract>The metabolic changes in hippocampus, temporal cortex and prefrontal cortex in SD rats along with aging were explored using a metabonomic approach, which based on high resolution “magic angle spinning”
1H NMR spectroscopy. The metabolite profiles were analyzed by partial least squares-discriminant analysis, and the results showed that the metabolites of the above three brain regions in old rats were dramatically different from that in the adult and young rats. The old rats showed increased myo-inositol and lactate in all of the three brain regions, and decreased N-acetylaspartate in temporal and frontal cortex, Glutamate–GABA level became imbalance in temporal cortex of old rats. In addition, compared with the adult female rats, male rats had higher levels of N-acetylaspartate, taurine, and creatine in temporal or frontal cortex. The age-related metabolic changes may indicate the early functional alterations of neural cells in these brain regions, especially the temporal cortex. The gender-related metabolic changes suggest the significance of the hormonal regulation in brain metabolism. Our work highlights the potential of metabolic profiling to enhance our understanding of biological mechanisms of brain aging.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19428792</pmid><doi>10.1016/j.neuint.2009.02.004</doi><tpages>7</tpages></addata></record> |
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| subjects | Age Aging - metabolism Amino Acids - metabolism Animals Biological and medical sciences Brain Chemistry Female Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus - growth & development Hippocampus - metabolism Least-Squares Analysis Magnetic Resonance Spectroscopy Male Memory - physiology Metabolomics Metabonomic Multivariate Analysis NMR Partial least squares-discriminant analysis Prefrontal cortex Prefrontal Cortex - growth & development Prefrontal Cortex - metabolism Rats Rats, Sprague-Dawley Sex Characteristics Temporal cortex Temporal Lobe - growth & development Temporal Lobe - metabolism Vertebrates: nervous system and sense organs |
| title | Metabonomic alterations in hippocampus, temporal and prefrontal cortex with age in rats |
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