Neurochemical evidence that stimulation of CB1 cannabinoid receptors on GABAergic nerve terminals activates the dopaminergic reward system by increasing dopamine release in the rat nucleus accumbens

We examined the effect of cannabinoid receptor activation on basal and electrical field simulation-evoked (25 V, 2 Hz, 240 shocks) [ 3H]dopamine efflux in the isolated rat nucleus accumbens in a preparation, in which any effect on the dendrites or somata of ventral tegmental projection neurons was e...

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Veröffentlicht in:	Neurochemistry international 2009-06, Vol.54 (7), p.452-457
Hauptverfasser:	Sperlágh, Beáta, Windisch, Katalin, Andó, Rómeó D., Sylvester Vizi, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anandamide Animals Benzoxazines - pharmacology Bicuculline - pharmacology Biological and medical sciences Cannabinoid CB1 receptor Dopamine Dopamine - metabolism Dopamine - physiology Electric Stimulation Fundamental and applied biological sciences. Psychology GABA GABA Antagonists - pharmacology GABA-A Receptor Antagonists gamma-Aminobutyric Acid - physiology Male Morpholines - pharmacology Naphthalenes - pharmacology Nerve Endings - drug effects Nucleus accumbens Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Piperidines - pharmacology Pyrazoles - pharmacology Rats Rats, Wistar Receptor, Cannabinoid, CB1 - agonists Release Reward Vertebrates: nervous system and sense organs
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