Activated liver dendritic cells generate strong acquired immunity in α-galactosylceramide treatment

Background/Aims α-Galactosylceramide (α-GalCer) presented by dendritic cells (DCs) activates NKT cells that in turn drive DC maturation. However, the potential of generating acquired immunity of liver DCs in α-GalCer treatment remains unclear. Methods We examined the activation of acquired immunity...

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Veröffentlicht in:	Journal of hepatology 2009-06, Vol.50 (6), p.1155-1162
Hauptverfasser:	Sasakawa, Akira, Tatsumi, Tomohide, Takehara, Tetsuo, Yamaguchi, Shinjiro, Yamamoto, Masashi, Ohkawa, Kazuyoshi, Miyagi, Takuya, Hayashi, Norio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired antitumor immunity Animals Antigen Presentation Biological and medical sciences Cell Line, Tumor Cytokines - biosynthesis Dendritic Cells - drug effects Dendritic Cells - immunology Female Galactosylceramides - immunology Galactosylceramides - pharmacology Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Immunotherapy Liver - cytology Liver - drug effects Liver - immunology Liver dendritic cells Liver Neoplasms, Experimental - immunology Liver Neoplasms, Experimental - pathology Liver Neoplasms, Experimental - therapy Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Sarcoma, Experimental - immunology Sarcoma, Experimental - pathology Sarcoma, Experimental - therapy Spleen - cytology Spleen - drug effects Spleen - immunology Splenic Neoplasms - immunology Splenic Neoplasms - pathology Splenic Neoplasms - therapy T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Tumor Suppressor Protein p53 - immunology α-Galactosylceramide
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