Prognostic impact of WT1 mutations in cytogenetically normal acute myeloid leukemia: a study of the German-Austrian AML Study Group

To evaluate the incidence and clinical impact of WT1 gene mutations in younger adult patients with cytogenetically normal acute myeloid leukemia (CN-AML), sequencing of the complete coding region was performed in diagnostic samples from 617 patients who were treated on 3 German-Austrian AML Study Gr...

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Veröffentlicht in:	Blood 2009-05, Vol.113 (19), p.4505-4511
Hauptverfasser:	Gaidzik, Verena Ingeborg, Schlenk, Richard Friedrich, Moschny, Simone, Becker, Annegret, Bullinger, Lars, Corbacioglu, Andrea, Krauter, Jürgen, Schlegelberger, Brigitte, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze, for the German-Austrian AML Study Group
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use Austria Biological and medical sciences Biomarkers, Tumor - genetics Cohort Studies Cytogenetic Analysis Female fms-Like Tyrosine Kinase 3 - genetics Germany Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Mutation - genetics Prognosis Survival Rate Tandem Repeat Sequences - genetics WT1 Proteins - genetics Young Adult
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