α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

α-Synuclein (α-Syn) abnormality and mitochondrial deficiency are two major changes in the brain of patients with Parkinson's disease (PD). A link between α-Syn and mitochondria in PD has been demonstrated by a recent study showing that accumulation of α-Syn in the mitochondria from the PD-vulne...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience letters 2009-05, Vol.454 (3), p.187-192
Hauptverfasser:	Liu, Guangwei, Zhang, Chunyan, Yin, Juanjuan, Li, Xin, Cheng, Furong, Li, Yaohua, Yang, Hui, Uéda, Kenji, Chan, Piu, Yu, Shun
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - biosynthesis Animals Biological and medical sciences Blotting, Western Brain Brain - metabolism Complex I Cytoplasm - chemistry Cytoplasm - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Down-Regulation Electron Transport Complex I - metabolism Fundamental and applied biological sciences. Psychology Male Medical sciences Mitochondria - chemistry Mitochondria - metabolism Mitochondrion Neurology Parkinson's disease Protein Transport Rats Rats, Wistar Vertebrates: nervous system and sense organs α-Synuclein
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!