Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet
To investigate the effects of centipede acidic protein (CAP) on atherosclerotic rats and the mechanisms involved. Male Sprague–Dawley rats were randomly divided into five groups: control, atherosclerotic, low-dose CAP (L-CAP), high-dose CAP (H-CAP) and simvastatin group ( n = 12 in each group). Athe...
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| Veröffentlicht in: | Journal of ethnopharmacology 2009-04, Vol.122 (3), p.509-516 |
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| creator | Wu, Yanling Li, Junyun Wang, Jusu Si, Qiuju Zhang, Jianping Jiang, Ye Chu, Li |
| description | To investigate the effects of centipede acidic protein (CAP) on atherosclerotic rats and the mechanisms involved.
Male Sprague–Dawley rats were randomly divided into five groups: control, atherosclerotic, low-dose CAP (L-CAP), high-dose CAP (H-CAP) and simvastatin group (
n
=
12 in each group). Atherosclerotic model was established by a single dose of vitamin D
3 and an atherogenic diet. Rats of H-CAP and simvastatin groups simultaneously received CAP or simvastatin daily for 6 weeks. At the completion of the experiment, the changes in lipid profile, hemorrheology, nitric oxide (NO), endothelin-1 (ET-1), malondialdehyde (MDA) and superoxide desmutase (SOD) were measured, and the histological changes in aorta and liver were observed.
Treatment of atherosclerotic rats with either low or high doses of CAP led not only to significant decreases in plasma total cholesterol, triglyceride, low density lipoprotein and increase in plasma high density lipoprotein, but also to improvement of the hemorrheologic abnormalities. On the other hand, CAP suppressed the lipid peroxidation, regulated the levels of ET-1 and NO. From the histopathological examination, treatment with CAP ameliorated the pathological changes in thoracic aorta and liver in atherosclerotic rats.
These results suggest that CAP significantly suppress the development of atherosclerosis, improves the hemorrheological disturbances and histopathological changes in the atherogenic diet fed rat model. These effects may partly attribute to reverse of dyslipidemia, inhibition of lipid peroxidation, regulation of NO and ET-1 system. |
| doi_str_mv | 10.1016/j.jep.2009.01.017 |
| format | Article |
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Male Sprague–Dawley rats were randomly divided into five groups: control, atherosclerotic, low-dose CAP (L-CAP), high-dose CAP (H-CAP) and simvastatin group (
n
=
12 in each group). Atherosclerotic model was established by a single dose of vitamin D
3 and an atherogenic diet. Rats of H-CAP and simvastatin groups simultaneously received CAP or simvastatin daily for 6 weeks. At the completion of the experiment, the changes in lipid profile, hemorrheology, nitric oxide (NO), endothelin-1 (ET-1), malondialdehyde (MDA) and superoxide desmutase (SOD) were measured, and the histological changes in aorta and liver were observed.
Treatment of atherosclerotic rats with either low or high doses of CAP led not only to significant decreases in plasma total cholesterol, triglyceride, low density lipoprotein and increase in plasma high density lipoprotein, but also to improvement of the hemorrheologic abnormalities. On the other hand, CAP suppressed the lipid peroxidation, regulated the levels of ET-1 and NO. From the histopathological examination, treatment with CAP ameliorated the pathological changes in thoracic aorta and liver in atherosclerotic rats.
These results suggest that CAP significantly suppress the development of atherosclerosis, improves the hemorrheological disturbances and histopathological changes in the atherogenic diet fed rat model. These effects may partly attribute to reverse of dyslipidemia, inhibition of lipid peroxidation, regulation of NO and ET-1 system.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2009.01.017</identifier><identifier>PMID: 19429321</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Acids ; animal disease models ; animal proteins ; Animals ; Anticholesteremic Agents - pharmacology ; aorta ; Aorta - drug effects ; Aorta - pathology ; Arthropods ; atherogenesis ; Atherosclerosis ; Atherosclerosis - pathology ; Atherosclerosis - prevention & control ; Biological and medical sciences ; Centipede acidic protein ; cholesterol ; diet ; Diet, Atherogenic ; Disease Models, Animal ; dose response ; Dyslipidemia ; Endothelin-1 - blood ; endothelins ; General pharmacology ; Hemorheology - drug effects ; Hemorrheology ; high density lipoprotein ; Hypolipidemic Agents - pharmacology ; lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids - blood ; liver ; low density lipoprotein ; Male ; malondialdehyde ; Malondialdehyde - blood ; Medical sciences ; medicinal properties ; Medicine, Chinese Traditional ; nitric oxide ; Nitric Oxide - blood ; Oriental traditional medicine ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Proteins ; Rats ; Rats, Sprague-Dawley ; rheological properties ; Scolopendra ; Scolopendra subspinipes ; Simvastatin - pharmacology ; superoxide dismutase ; Superoxide Dismutase - blood ; triacylglycerols</subject><ispartof>Journal of ethnopharmacology, 2009-04, Vol.122 (3), p.509-516</ispartof><rights>2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-4492da343273201a70ed7e0ba80fc63e04c89f70734956f4853b294de719d8ef3</citedby><cites>FETCH-LOGICAL-c502t-4492da343273201a70ed7e0ba80fc63e04c89f70734956f4853b294de719d8ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2009.01.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21399093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19429321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Yanling</creatorcontrib><creatorcontrib>Li, Junyun</creatorcontrib><creatorcontrib>Wang, Jusu</creatorcontrib><creatorcontrib>Si, Qiuju</creatorcontrib><creatorcontrib>Zhang, Jianping</creatorcontrib><creatorcontrib>Jiang, Ye</creatorcontrib><creatorcontrib>Chu, Li</creatorcontrib><title>Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>To investigate the effects of centipede acidic protein (CAP) on atherosclerotic rats and the mechanisms involved.
Male Sprague–Dawley rats were randomly divided into five groups: control, atherosclerotic, low-dose CAP (L-CAP), high-dose CAP (H-CAP) and simvastatin group (
n
=
12 in each group). Atherosclerotic model was established by a single dose of vitamin D
3 and an atherogenic diet. Rats of H-CAP and simvastatin groups simultaneously received CAP or simvastatin daily for 6 weeks. At the completion of the experiment, the changes in lipid profile, hemorrheology, nitric oxide (NO), endothelin-1 (ET-1), malondialdehyde (MDA) and superoxide desmutase (SOD) were measured, and the histological changes in aorta and liver were observed.
Treatment of atherosclerotic rats with either low or high doses of CAP led not only to significant decreases in plasma total cholesterol, triglyceride, low density lipoprotein and increase in plasma high density lipoprotein, but also to improvement of the hemorrheologic abnormalities. On the other hand, CAP suppressed the lipid peroxidation, regulated the levels of ET-1 and NO. From the histopathological examination, treatment with CAP ameliorated the pathological changes in thoracic aorta and liver in atherosclerotic rats.
These results suggest that CAP significantly suppress the development of atherosclerosis, improves the hemorrheological disturbances and histopathological changes in the atherogenic diet fed rat model. These effects may partly attribute to reverse of dyslipidemia, inhibition of lipid peroxidation, regulation of NO and ET-1 system.</description><subject>Acids</subject><subject>animal disease models</subject><subject>animal proteins</subject><subject>Animals</subject><subject>Anticholesteremic Agents - pharmacology</subject><subject>aorta</subject><subject>Aorta - drug effects</subject><subject>Aorta - pathology</subject><subject>Arthropods</subject><subject>atherogenesis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - pathology</subject><subject>Atherosclerosis - prevention & control</subject><subject>Biological and medical sciences</subject><subject>Centipede acidic protein</subject><subject>cholesterol</subject><subject>diet</subject><subject>Diet, Atherogenic</subject><subject>Disease Models, Animal</subject><subject>dose response</subject><subject>Dyslipidemia</subject><subject>Endothelin-1 - blood</subject><subject>endothelins</subject><subject>General pharmacology</subject><subject>Hemorheology - drug effects</subject><subject>Hemorrheology</subject><subject>high density lipoprotein</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids - blood</subject><subject>liver</subject><subject>low density lipoprotein</subject><subject>Male</subject><subject>malondialdehyde</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>medicinal properties</subject><subject>Medicine, Chinese Traditional</subject><subject>nitric oxide</subject><subject>Nitric Oxide - blood</subject><subject>Oriental traditional medicine</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>rheological properties</subject><subject>Scolopendra</subject><subject>Scolopendra subspinipes</subject><subject>Simvastatin - pharmacology</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - blood</subject><subject>triacylglycerols</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9PGzEQxa2KqgTaD8AF9tLeNh3_2fVanKKopUhIPRDOlmOPwVGyG-wNUr89A4lKT0V6kg_ze8-jN4ydcZhy4O331XSF26kAMFPgJP2BTXinRa0bLY_YBKTu6k4rfsxOSlkBgOYKPrFjbpQwUvAJW8z6MdVufMA83GOffIUxoh9LNcTKIw23GLByPgWabfMwYuorUnbERAyV66t_7SHh-Jl9jG5d8MvhPWV3P38s5r_qm99X1_PZTe0bEGOtlBHBSSWFlgK404BBIyxdB9G3EkH5zkQNWirTtFF1jVwKowJqbkKHUZ6yb_tc2utxh2W0m1Q8rteux2FXbKuFaDTv3gVfKjStUQTyPejzUErGaLc5bVz-YznYl87tylLnrwYLnKTJc34I3y03GN4ch5IJ-HoAXPFuHbPrfSp_OSKMASOJu9hz0Q3W3Wdi7m6pGEn_UphpiLjcE0itPiXMtviEvceQMh3NhiH9Z9FnZVWmng</recordid><startdate>20090421</startdate><enddate>20090421</enddate><creator>Wu, Yanling</creator><creator>Li, Junyun</creator><creator>Wang, Jusu</creator><creator>Si, Qiuju</creator><creator>Zhang, Jianping</creator><creator>Jiang, Ye</creator><creator>Chu, Li</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>7X8</scope></search><sort><creationdate>20090421</creationdate><title>Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet</title><author>Wu, Yanling ; Li, Junyun ; Wang, Jusu ; Si, Qiuju ; Zhang, Jianping ; Jiang, Ye ; Chu, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-4492da343273201a70ed7e0ba80fc63e04c89f70734956f4853b294de719d8ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acids</topic><topic>animal disease models</topic><topic>animal proteins</topic><topic>Animals</topic><topic>Anticholesteremic Agents - pharmacology</topic><topic>aorta</topic><topic>Aorta - drug effects</topic><topic>Aorta - pathology</topic><topic>Arthropods</topic><topic>atherogenesis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - pathology</topic><topic>Atherosclerosis - prevention & control</topic><topic>Biological and medical sciences</topic><topic>Centipede acidic protein</topic><topic>cholesterol</topic><topic>diet</topic><topic>Diet, Atherogenic</topic><topic>Disease Models, Animal</topic><topic>dose response</topic><topic>Dyslipidemia</topic><topic>Endothelin-1 - blood</topic><topic>endothelins</topic><topic>General pharmacology</topic><topic>Hemorheology - drug effects</topic><topic>Hemorrheology</topic><topic>high density lipoprotein</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids - blood</topic><topic>liver</topic><topic>low density lipoprotein</topic><topic>Male</topic><topic>malondialdehyde</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>medicinal properties</topic><topic>Medicine, Chinese Traditional</topic><topic>nitric oxide</topic><topic>Nitric Oxide - blood</topic><topic>Oriental traditional medicine</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>rheological properties</topic><topic>Scolopendra</topic><topic>Scolopendra subspinipes</topic><topic>Simvastatin - pharmacology</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - blood</topic><topic>triacylglycerols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yanling</creatorcontrib><creatorcontrib>Li, Junyun</creatorcontrib><creatorcontrib>Wang, Jusu</creatorcontrib><creatorcontrib>Si, Qiuju</creatorcontrib><creatorcontrib>Zhang, Jianping</creatorcontrib><creatorcontrib>Jiang, Ye</creatorcontrib><creatorcontrib>Chu, Li</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yanling</au><au>Li, Junyun</au><au>Wang, Jusu</au><au>Si, Qiuju</au><au>Zhang, Jianping</au><au>Jiang, Ye</au><au>Chu, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2009-04-21</date><risdate>2009</risdate><volume>122</volume><issue>3</issue><spage>509</spage><epage>516</epage><pages>509-516</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>To investigate the effects of centipede acidic protein (CAP) on atherosclerotic rats and the mechanisms involved.
Male Sprague–Dawley rats were randomly divided into five groups: control, atherosclerotic, low-dose CAP (L-CAP), high-dose CAP (H-CAP) and simvastatin group (
n
=
12 in each group). Atherosclerotic model was established by a single dose of vitamin D
3 and an atherogenic diet. Rats of H-CAP and simvastatin groups simultaneously received CAP or simvastatin daily for 6 weeks. At the completion of the experiment, the changes in lipid profile, hemorrheology, nitric oxide (NO), endothelin-1 (ET-1), malondialdehyde (MDA) and superoxide desmutase (SOD) were measured, and the histological changes in aorta and liver were observed.
Treatment of atherosclerotic rats with either low or high doses of CAP led not only to significant decreases in plasma total cholesterol, triglyceride, low density lipoprotein and increase in plasma high density lipoprotein, but also to improvement of the hemorrheologic abnormalities. On the other hand, CAP suppressed the lipid peroxidation, regulated the levels of ET-1 and NO. From the histopathological examination, treatment with CAP ameliorated the pathological changes in thoracic aorta and liver in atherosclerotic rats.
These results suggest that CAP significantly suppress the development of atherosclerosis, improves the hemorrheological disturbances and histopathological changes in the atherogenic diet fed rat model. These effects may partly attribute to reverse of dyslipidemia, inhibition of lipid peroxidation, regulation of NO and ET-1 system.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19429321</pmid><doi>10.1016/j.jep.2009.01.017</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of ethnopharmacology, 2009-04, Vol.122 (3), p.509-516 |
| issn | 0378-8741 1872-7573 |
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| subjects | Acids animal disease models animal proteins Animals Anticholesteremic Agents - pharmacology aorta Aorta - drug effects Aorta - pathology Arthropods atherogenesis Atherosclerosis Atherosclerosis - pathology Atherosclerosis - prevention & control Biological and medical sciences Centipede acidic protein cholesterol diet Diet, Atherogenic Disease Models, Animal dose response Dyslipidemia Endothelin-1 - blood endothelins General pharmacology Hemorheology - drug effects Hemorrheology high density lipoprotein Hypolipidemic Agents - pharmacology lipid peroxidation Lipid Peroxidation - drug effects Lipids - blood liver low density lipoprotein Male malondialdehyde Malondialdehyde - blood Medical sciences medicinal properties Medicine, Chinese Traditional nitric oxide Nitric Oxide - blood Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Proteins Rats Rats, Sprague-Dawley rheological properties Scolopendra Scolopendra subspinipes Simvastatin - pharmacology superoxide dismutase Superoxide Dismutase - blood triacylglycerols |
| title | Anti-atherogenic effects of centipede acidic protein in rats fed an atherogenic diet |
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