Acute effects of glucose and insulin on vascular endothelium

Chronic exposure to high concentrations of glucose has consistently been demonstrated to impair endothelium-dependent, nitric oxide (NO)-mediated vasodilation. In contrast, several clinical investigations have reported that acute exposure to high glucose, alone or in combination with insulin, trigge...

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Veröffentlicht in:	Diabetologia 2004-12, Vol.47 (12), p.2059-2071
Hauptverfasser:	TAUBERT, D, ROSENKRANZ, A, BERKELS, R, ROESEN, R, SCHÖMIG, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiloride - analogs & derivatives Amiloride - pharmacology Animals Aorta Biological and medical sciences Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose Glucose - pharmacology Hyperglycemia Insulin - pharmacology Insulin resistance Kinetics Medical sciences Muscle Tonus - drug effects Muscle Tonus - physiology Nitric oxide Nitric Oxide - metabolism Phlorhizin - pharmacology Sucrose - pharmacology Superoxides - metabolism Swine
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