Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor
To determine the effect of diabetes on reproductive performance, two kinds of diabetes mice, i.e., KK/TaJcl mice with Type-II diabetes and Streptozotocin-induced diabetes mice with Type-I diabetes, were used in this study. Particular attention was paid to uterine natural killer (uNK) cells and place...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2009, Vol.71(4), pp.519-523 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | PHICHITRASILP, Thanmaporn HONDO, Eiichi RERKAMNUAYCHOKE, Worawut WAKITANI, Shoichi SUGIYAMA, Makoto TERAKAWA, Jumpei KISO, Yasuo |
| description | To determine the effect of diabetes on reproductive performance, two kinds of diabetes mice, i.e., KK/TaJcl mice with Type-II diabetes and Streptozotocin-induced diabetes mice with Type-I diabetes, were used in this study. Particular attention was paid to uterine natural killer (uNK) cells and placental growth factor (PlGF). The number of fetuses, the fetal and placental weights in both diabetes mice were significantly decreased when compared to controls. Surprisingly, uNK cells in both diabetes mice persisted in the metrial gland even at the term of pregnancy. Although PlGF expression in both diabetes mice was significantly decreased, PlGF protein did not change. These results show that diabetes condition affects reproductive performance, particularly uNK cell behavior, but not PlGF production. |
| doi_str_mv | 10.1292/jvms.71.519 |
| format | Article |
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Particular attention was paid to uterine natural killer (uNK) cells and placental growth factor (PlGF). The number of fetuses, the fetal and placental weights in both diabetes mice were significantly decreased when compared to controls. Surprisingly, uNK cells in both diabetes mice persisted in the metrial gland even at the term of pregnancy. Although PlGF expression in both diabetes mice was significantly decreased, PlGF protein did not change. These results show that diabetes condition affects reproductive performance, particularly uNK cell behavior, but not PlGF production.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.71.519</identifier><identifier>PMID: 19420861</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; Blotting, Western ; Body Weight - physiology ; diabetes ; Diabetes Mellitus, Experimental - immunology ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes Mellitus, Type 1 - immunology ; Diabetes Mellitus, Type 1 - physiopathology ; Diabetes Mellitus, Type 2 - immunology ; Disease Models, Animal ; Female ; Killer Cells, Natural - pathology ; Mice ; Mice, Inbred ICR ; Placenta - cytology ; Placenta - immunology ; Placenta Growth Factor ; placental growth factor ; Pregnancy ; Pregnancy Proteins - genetics ; Pregnancy Proteins - immunology ; Pregnancy Proteins - physiology ; Reproduction - immunology ; Reproduction - physiology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA - chemistry ; RNA - genetics ; uterine natural killer cell</subject><ispartof>Journal of Veterinary Medical Science, 2009, Vol.71(4), pp.519-523</ispartof><rights>2009 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-4770bd5466d05ba3a2e532caf88de90ebb5b1acd0eac9ced6fd667f99178c7fd3</citedby><cites>FETCH-LOGICAL-c464t-4770bd5466d05ba3a2e532caf88de90ebb5b1acd0eac9ced6fd667f99178c7fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19420861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PHICHITRASILP, Thanmaporn</creatorcontrib><creatorcontrib>HONDO, Eiichi</creatorcontrib><creatorcontrib>RERKAMNUAYCHOKE, Worawut</creatorcontrib><creatorcontrib>WAKITANI, Shoichi</creatorcontrib><creatorcontrib>SUGIYAMA, Makoto</creatorcontrib><creatorcontrib>TERAKAWA, Jumpei</creatorcontrib><creatorcontrib>KISO, Yasuo</creatorcontrib><title>Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>To determine the effect of diabetes on reproductive performance, two kinds of diabetes mice, i.e., KK/TaJcl mice with Type-II diabetes and Streptozotocin-induced diabetes mice with Type-I diabetes, were used in this study. Particular attention was paid to uterine natural killer (uNK) cells and placental growth factor (PlGF). The number of fetuses, the fetal and placental weights in both diabetes mice were significantly decreased when compared to controls. Surprisingly, uNK cells in both diabetes mice persisted in the metrial gland even at the term of pregnancy. Although PlGF expression in both diabetes mice was significantly decreased, PlGF protein did not change. These results show that diabetes condition affects reproductive performance, particularly uNK cell behavior, but not PlGF production.</description><subject>Animals</subject><subject>Blotting, Western</subject><subject>Body Weight - physiology</subject><subject>diabetes</subject><subject>Diabetes Mellitus, Experimental - immunology</subject><subject>Diabetes Mellitus, Experimental - physiopathology</subject><subject>Diabetes Mellitus, Type 1 - immunology</subject><subject>Diabetes Mellitus, Type 1 - physiopathology</subject><subject>Diabetes Mellitus, Type 2 - immunology</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Killer Cells, Natural - pathology</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Placenta - cytology</subject><subject>Placenta - immunology</subject><subject>Placenta Growth Factor</subject><subject>placental growth factor</subject><subject>Pregnancy</subject><subject>Pregnancy Proteins - genetics</subject><subject>Pregnancy Proteins - immunology</subject><subject>Pregnancy Proteins - physiology</subject><subject>Reproduction - immunology</subject><subject>Reproduction - physiology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA - chemistry</subject><subject>RNA - genetics</subject><subject>uterine natural killer cell</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEYhonR2LV68m5ITLyYWYFhYLjZrLYaqzbVnsk38I1lMzuzAtPGi79dNrtZEy9eIOF98sDHS8hzzpZcGPFmfbdJS82XDTcPyILXUlda1uYhWTDDVaVFw07Ik5TWjAkulXlMTriRgrWKL8jva9zGyc8uhzukVxj7KW5gdEjDSN8F6DBjop9DObgP-ZYC_bZFF2Cg19hjxB2ZJ3qTMYYR6RfIcyzhpzAMGOkKhyFRGD29GsDhmEt0Eaf7IjoHl6f4lDzqYUj47LCfkpvz999XH6rLrxcfV2eXlZNK5kpqzTrfSKU8azqoQWBTCwd923o0DLuu6Tg4zxCccehV75XSvTFct073vj4lr_beMuzPGVO2m5BceR2MOM3JKi0Eb0z7X1AwJZQ0dQFf_gOupzmOZQhbPrnV5WapC_V6T7k4pRSxt9sYNhB_Wc7srj27a89qbkt7hX5xcM7dBv1f9lBXAd7ugXXK8AOPAMQc3IBHmdwvxXmM3C1Ei2P9B0H3rs0</recordid><startdate>20090401</startdate><enddate>20090401</enddate><creator>PHICHITRASILP, Thanmaporn</creator><creator>HONDO, Eiichi</creator><creator>RERKAMNUAYCHOKE, Worawut</creator><creator>WAKITANI, Shoichi</creator><creator>SUGIYAMA, Makoto</creator><creator>TERAKAWA, Jumpei</creator><creator>KISO, Yasuo</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>20090401</creationdate><title>Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor</title><author>PHICHITRASILP, Thanmaporn ; HONDO, Eiichi ; RERKAMNUAYCHOKE, Worawut ; WAKITANI, Shoichi ; SUGIYAMA, Makoto ; TERAKAWA, Jumpei ; KISO, Yasuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-4770bd5466d05ba3a2e532caf88de90ebb5b1acd0eac9ced6fd667f99178c7fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Blotting, Western</topic><topic>Body Weight - physiology</topic><topic>diabetes</topic><topic>Diabetes Mellitus, Experimental - immunology</topic><topic>Diabetes Mellitus, Experimental - physiopathology</topic><topic>Diabetes Mellitus, Type 1 - immunology</topic><topic>Diabetes Mellitus, Type 1 - physiopathology</topic><topic>Diabetes Mellitus, Type 2 - immunology</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Killer Cells, Natural - pathology</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Placenta - cytology</topic><topic>Placenta - immunology</topic><topic>Placenta Growth Factor</topic><topic>placental growth factor</topic><topic>Pregnancy</topic><topic>Pregnancy Proteins - genetics</topic><topic>Pregnancy Proteins - immunology</topic><topic>Pregnancy Proteins - physiology</topic><topic>Reproduction - immunology</topic><topic>Reproduction - physiology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA - chemistry</topic><topic>RNA - genetics</topic><topic>uterine natural killer cell</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PHICHITRASILP, Thanmaporn</creatorcontrib><creatorcontrib>HONDO, Eiichi</creatorcontrib><creatorcontrib>RERKAMNUAYCHOKE, Worawut</creatorcontrib><creatorcontrib>WAKITANI, Shoichi</creatorcontrib><creatorcontrib>SUGIYAMA, Makoto</creatorcontrib><creatorcontrib>TERAKAWA, Jumpei</creatorcontrib><creatorcontrib>KISO, Yasuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Immunology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PHICHITRASILP, Thanmaporn</au><au>HONDO, Eiichi</au><au>RERKAMNUAYCHOKE, Worawut</au><au>WAKITANI, Shoichi</au><au>SUGIYAMA, Makoto</au><au>TERAKAWA, Jumpei</au><au>KISO, Yasuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2009-04-01</date><risdate>2009</risdate><volume>71</volume><issue>4</issue><spage>519</spage><epage>523</epage><pages>519-523</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>To determine the effect of diabetes on reproductive performance, two kinds of diabetes mice, i.e., KK/TaJcl mice with Type-II diabetes and Streptozotocin-induced diabetes mice with Type-I diabetes, were used in this study. Particular attention was paid to uterine natural killer (uNK) cells and placental growth factor (PlGF). The number of fetuses, the fetal and placental weights in both diabetes mice were significantly decreased when compared to controls. Surprisingly, uNK cells in both diabetes mice persisted in the metrial gland even at the term of pregnancy. Although PlGF expression in both diabetes mice was significantly decreased, PlGF protein did not change. 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| subjects | Animals Blotting, Western Body Weight - physiology diabetes Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - physiopathology Diabetes Mellitus, Type 2 - immunology Disease Models, Animal Female Killer Cells, Natural - pathology Mice Mice, Inbred ICR Placenta - cytology Placenta - immunology Placenta Growth Factor placental growth factor Pregnancy Pregnancy Proteins - genetics Pregnancy Proteins - immunology Pregnancy Proteins - physiology Reproduction - immunology Reproduction - physiology Reverse Transcriptase Polymerase Chain Reaction RNA - chemistry RNA - genetics uterine natural killer cell |
| title | Reproductive Performance in Diabetes Mice with a Special Reference to Uterine Natural Killer Cells and Placental Growth Factor |
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