Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development
Primary central nervous system (CNS) lymphoma is an aggressive B-cell tumor that is defined clinically by the absence of systemic disease. We have used immunoglobulin variable (V)–gene analysis to identify tumor cells at the CNS site in 12 cases and to probe the involvement of peripheral tissues in...
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| Veröffentlicht in: | Blood 2009-05, Vol.113 (19), p.4677-4680 |
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| creator | McCann, Katy J. Ashton-Key, Margaret Smith, KellyAnn Stevenson, Freda K. Ottensmeier, Christian H. |
| description | Primary central nervous system (CNS) lymphoma is an aggressive B-cell tumor that is defined clinically by the absence of systemic disease. We have used immunoglobulin variable (V)–gene analysis to identify tumor cells at the CNS site in 12 cases and to probe the involvement of peripheral tissues in 3 patients. Clonal tracking revealed tumor cells in the bone marrow and/or blood for 3 of 3 cases, with evidence for increased V-gene mutational activity at peripheral sites. In 2 of 3 cases, intraclonal variant analysis revealed identity with the brain biopsy but detected additional variants unique to extracerebral sites. These findings suggest that peripheral tumor cells can undergo separate development locally with no reentry into the brain. Primary CNS lymphoma appears to have both CNS-specific and systemic components with limited interchange. The more malignant behavior of tumor cells in the CNS suggests either a local environmental influence or a less malignant phenotype of the peripheral clone. |
| doi_str_mv | 10.1182/blood-2008-09-179366 |
| format | Article |
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We have used immunoglobulin variable (V)–gene analysis to identify tumor cells at the CNS site in 12 cases and to probe the involvement of peripheral tissues in 3 patients. Clonal tracking revealed tumor cells in the bone marrow and/or blood for 3 of 3 cases, with evidence for increased V-gene mutational activity at peripheral sites. In 2 of 3 cases, intraclonal variant analysis revealed identity with the brain biopsy but detected additional variants unique to extracerebral sites. These findings suggest that peripheral tumor cells can undergo separate development locally with no reentry into the brain. Primary CNS lymphoma appears to have both CNS-specific and systemic components with limited interchange. The more malignant behavior of tumor cells in the CNS suggests either a local environmental influence or a less malignant phenotype of the peripheral clone.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2008-09-179366</identifier><identifier>PMID: 19096008</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Base Sequence ; Biological and medical sciences ; Bone Marrow - pathology ; Brain Neoplasms - blood ; Brain Neoplasms - diagnosis ; Brain Neoplasms - genetics ; Central Nervous System Neoplasms - blood ; Central Nervous System Neoplasms - diagnosis ; Central Nervous System Neoplasms - genetics ; Clone Cells - immunology ; Clone Cells - pathology ; Cytidine Deaminase - genetics ; Cytidine Deaminase - metabolism ; Gene Rearrangement ; Hematologic and hematopoietic diseases ; Humans ; Immunoenzyme Techniques ; Immunoglobulin Variable Region - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Large B-Cell, Diffuse - blood ; Lymphoma, Large B-Cell, Diffuse - diagnosis ; Lymphoma, Large B-Cell, Diffuse - genetics ; Medical sciences ; Molecular Sequence Data ; Mutation ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Homology, Nucleic Acid</subject><ispartof>Blood, 2009-05, Vol.113 (19), p.4677-4680</ispartof><rights>2009 American Society of Hematology</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-62ed17b1e71009547da69ab3b7087e269266ffb22e54cde180aa55d3b83f2f63</citedby><cites>FETCH-LOGICAL-c436t-62ed17b1e71009547da69ab3b7087e269266ffb22e54cde180aa55d3b83f2f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21474090$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19096008$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCann, Katy J.</creatorcontrib><creatorcontrib>Ashton-Key, Margaret</creatorcontrib><creatorcontrib>Smith, KellyAnn</creatorcontrib><creatorcontrib>Stevenson, Freda K.</creatorcontrib><creatorcontrib>Ottensmeier, Christian H.</creatorcontrib><title>Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development</title><title>Blood</title><addtitle>Blood</addtitle><description>Primary central nervous system (CNS) lymphoma is an aggressive B-cell tumor that is defined clinically by the absence of systemic disease. We have used immunoglobulin variable (V)–gene analysis to identify tumor cells at the CNS site in 12 cases and to probe the involvement of peripheral tissues in 3 patients. Clonal tracking revealed tumor cells in the bone marrow and/or blood for 3 of 3 cases, with evidence for increased V-gene mutational activity at peripheral sites. In 2 of 3 cases, intraclonal variant analysis revealed identity with the brain biopsy but detected additional variants unique to extracerebral sites. These findings suggest that peripheral tumor cells can undergo separate development locally with no reentry into the brain. Primary CNS lymphoma appears to have both CNS-specific and systemic components with limited interchange. The more malignant behavior of tumor cells in the CNS suggests either a local environmental influence or a less malignant phenotype of the peripheral clone.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Brain Neoplasms - blood</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - genetics</subject><subject>Central Nervous System Neoplasms - blood</subject><subject>Central Nervous System Neoplasms - diagnosis</subject><subject>Central Nervous System Neoplasms - genetics</subject><subject>Clone Cells - immunology</subject><subject>Clone Cells - pathology</subject><subject>Cytidine Deaminase - genetics</subject><subject>Cytidine Deaminase - metabolism</subject><subject>Gene Rearrangement</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunoglobulin Variable Region - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Large B-Cell, Diffuse - blood</subject><subject>Lymphoma, Large B-Cell, Diffuse - diagnosis</subject><subject>Lymphoma, Large B-Cell, Diffuse - genetics</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Mutation</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Sequence Homology, Nucleic Acid</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAURS0EotPCHyDkDexCn53EiVkgVVVbKlWCRfeWY79ojJw42J4p8wX8Np5mBDtWluxzr987hLxj8Imxnl8OPgRbcYC-AlmxTtZCvCAb1vJyARxekg0AiKqRHTsj5yn9AGBNzdvX5IxJkKIkN-T39-gmHQ_U4Jyj9nTGuA-7RNMhZZyoP0zLNkz6M827KcQqotcZLTU-zJgo_nIpUzfTvEX6PBHVs6VDeaSlNoYn-uTyluLeWZwN0jFEmnDRsbRQi3v0YZnK12_Iq1H7hG9P5wV5vL15vP5aPXy7u7--eqhMU4tcCY6WdQPDjgHItumsFlIP9dBB3yEXkgsxjgPn2DbGIutB67a19dDXIx9FfUE-rrVLDD93mLKaXDLovZ6xbK1ExzmDti1gs4ImhpQijmpZRSkG6uhfPW-rjv4VSLX6L7H3p_7dMKH9FzoJL8CHE6CT0X6MejYu_eU4a7oGJBTuy8phkbF3GFUy7mjQuogmKxvc_yf5A-gopwU</recordid><startdate>20090507</startdate><enddate>20090507</enddate><creator>McCann, Katy J.</creator><creator>Ashton-Key, Margaret</creator><creator>Smith, KellyAnn</creator><creator>Stevenson, Freda K.</creator><creator>Ottensmeier, Christian H.</creator><general>Elsevier Inc</general><general>Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090507</creationdate><title>Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development</title><author>McCann, Katy J. ; Ashton-Key, Margaret ; Smith, KellyAnn ; Stevenson, Freda K. ; Ottensmeier, Christian H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-62ed17b1e71009547da69ab3b7087e269266ffb22e54cde180aa55d3b83f2f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Brain Neoplasms - blood</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Brain Neoplasms - genetics</topic><topic>Central Nervous System Neoplasms - blood</topic><topic>Central Nervous System Neoplasms - diagnosis</topic><topic>Central Nervous System Neoplasms - genetics</topic><topic>Clone Cells - immunology</topic><topic>Clone Cells - pathology</topic><topic>Cytidine Deaminase - genetics</topic><topic>Cytidine Deaminase - metabolism</topic><topic>Gene Rearrangement</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunoglobulin Variable Region - genetics</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Large B-Cell, Diffuse - blood</topic><topic>Lymphoma, Large B-Cell, Diffuse - diagnosis</topic><topic>Lymphoma, Large B-Cell, Diffuse - genetics</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Mutation</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Sequence Homology, Nucleic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCann, Katy J.</creatorcontrib><creatorcontrib>Ashton-Key, Margaret</creatorcontrib><creatorcontrib>Smith, KellyAnn</creatorcontrib><creatorcontrib>Stevenson, Freda K.</creatorcontrib><creatorcontrib>Ottensmeier, Christian H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCann, Katy J.</au><au>Ashton-Key, Margaret</au><au>Smith, KellyAnn</au><au>Stevenson, Freda K.</au><au>Ottensmeier, Christian H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2009-05-07</date><risdate>2009</risdate><volume>113</volume><issue>19</issue><spage>4677</spage><epage>4680</epage><pages>4677-4680</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Primary central nervous system (CNS) lymphoma is an aggressive B-cell tumor that is defined clinically by the absence of systemic disease. We have used immunoglobulin variable (V)–gene analysis to identify tumor cells at the CNS site in 12 cases and to probe the involvement of peripheral tissues in 3 patients. Clonal tracking revealed tumor cells in the bone marrow and/or blood for 3 of 3 cases, with evidence for increased V-gene mutational activity at peripheral sites. In 2 of 3 cases, intraclonal variant analysis revealed identity with the brain biopsy but detected additional variants unique to extracerebral sites. These findings suggest that peripheral tumor cells can undergo separate development locally with no reentry into the brain. Primary CNS lymphoma appears to have both CNS-specific and systemic components with limited interchange. The more malignant behavior of tumor cells in the CNS suggests either a local environmental influence or a less malignant phenotype of the peripheral clone.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>19096008</pmid><doi>10.1182/blood-2008-09-179366</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Base Sequence Biological and medical sciences Bone Marrow - pathology Brain Neoplasms - blood Brain Neoplasms - diagnosis Brain Neoplasms - genetics Central Nervous System Neoplasms - blood Central Nervous System Neoplasms - diagnosis Central Nervous System Neoplasms - genetics Clone Cells - immunology Clone Cells - pathology Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Gene Rearrangement Hematologic and hematopoietic diseases Humans Immunoenzyme Techniques Immunoglobulin Variable Region - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Large B-Cell, Diffuse - blood Lymphoma, Large B-Cell, Diffuse - diagnosis Lymphoma, Large B-Cell, Diffuse - genetics Medical sciences Molecular Sequence Data Mutation RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Homology, Nucleic Acid |
| title | Primary central nervous system lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development |
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