Detection of Overexpressed and Phosphorylated Wild-Type Kit Receptor in Surgical Specimens of Small Cell Lung Cancer

Purpose: The combinations of various chemotherapeutic drugs currently used to treat advanced small cell lung cancer (SCLC) led to similarly poor survival outcomes, which is why new molecular biology approaches are needed to design and select targeted therapies. Experimental Design: Thirteen stage I...

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Veröffentlicht in:	Clinical cancer research 2004-12, Vol.10 (24), p.8214-8219
Hauptverfasser:	TAMBORINI, Elena, BONADIMAN, Lorena, NEGRI, Tiziana, GRECO, Angela, STAURENGO, Samantha, BIDOLI, Paolo, PASTORINO, Ugo, PIEROTTI, Marco A, PILOTTI, Silvana
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Antineoplastic agents Biological and medical sciences Blotting, Western Carcinoma, Small Cell - diagnosis Carcinoma, Small Cell - genetics Carcinoma, Small Cell - surgery Case-Control Studies Humans Immunoenzyme Techniques Immunoprecipitation Lung - metabolism Lung - pathology Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - surgery Medical sciences Mutation - genetics Pharmacology. Drug treatments Phosphorylation Pneumology Protein Isoforms Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism RNA, Messenger - metabolism Stem Cell Factor - genetics Stem Cell Factor - metabolism Tumors of the respiratory system and mediastinum Up-Regulation
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