Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver

In this study, we compared the regulation of CYP3A isozymes by the vitamin D receptor (VDR) ligand 1α,25-dihydroxyvitamin D 3 (1,25(OH) 2D 3) against ligands of the pregnane X receptor (PXR), the glucocorticoid receptor (GR) and the farnesoid X receptor (FXR) in precision-cut tissue slices of the ra...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2009-05, Vol.37 (2), p.115-125
Hauptverfasser:	Khan, Ansar A., Chow, Edwin C.Y., van Loenen-Weemaes, Anne-miek M.A., Porte, Robert J., Pang, K. Sandy, Groothuis, Geny M.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1α,25-Dihydroxyvitamin D 3 Animals Base Sequence Biological and medical sciences Cytochrome P-450 CYP3A - genetics Cytochrome P-450 CYP3A - metabolism Cytochrome P450 DNA Primers General pharmacology Humans In Vitro Techniques Induction Intestinal slices Intestines - enzymology Isoenzymes - genetics Isoenzymes - metabolism Ligands Liver - enzymology Liver slices Male Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymerase Chain Reaction Rats Rats, Wistar Receptors, Calcitriol - metabolism Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Glucocorticoid - metabolism Receptors, Steroid - metabolism
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