Development of Enteric-coated Timed-release Matrix Tablets for Colon Targeting

A new oral drug delivery system for colon targeting has been developed based on enteric-coated matrix tablets which suitably exploits both pH-sensitive and time-dependent functions. Matrix-tablets were prepared by direct compression of mixtures of hydroxyethylcellulose (HEC), a hydrophilic swellable...

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Veröffentlicht in:	Journal of drug targeting 2004, Vol.12 (9-10), p.607-612
Hauptverfasser:	Alvarez-Fuentes, J., Fernández-Arévalo, M., González-Rodríguez, M.L., Cirri, M., Mura, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry, Pharmaceutical Colon - metabolism Colon drug delivery Delayed-Action Preparations - chemical synthesis Delayed-Action Preparations - pharmacokinetics Drug Delivery Systems - methods Ethylcellulose Eudragit General pharmacology Hydroxyethylcellulose Medical sciences Microcrystalline cellulose Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Tablets, Enteric-Coated - chemical synthesis Tablets, Enteric-Coated - pharmacokinetics Theophylline
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