Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer

Aim: Investigation of possible effects of aqueous extract of urtica dioica leaves on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Methods: Ten prostate tissues from patients with pathologically proven localized prostate cancer (Gleason scores 4 to 7) were used...

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Veröffentlicht in:Cancer biology & therapy 2004-09, Vol.3 (9), p.855-857
Hauptverfasser: Durak, Ilker, Biri, Hasan, Devrim, Erdinç, Sözen, Sinan, Avcı, Aslıhan
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container_end_page 857
container_issue 9
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container_title Cancer biology & therapy
container_volume 3
creator Durak, Ilker
Biri, Hasan
Devrim, Erdinç
Sözen, Sinan
Avcı, Aslıhan
description Aim: Investigation of possible effects of aqueous extract of urtica dioica leaves on adenosine deaminase activity in prostate tissue from patients with prostate cancer. Methods: Ten prostate tissues from patients with pathologically proven localized prostate cancer (Gleason scores 4 to 7) were used in the study. In the tissues, ADA activities with and without preincubation with different amounts of urtica dioica extracts were performed. Results: Aqueous extract of urtica dioica results in significant inhibition on adenosine deaminase (ADA) activity of prostate tissue. Conclusion: ADA inhibition by urtica dioica extract might be one of the mechanisms in the observed beneficial effect of urtica dioica in prostate cancer.
doi_str_mv 10.4161/cbt.3.9.1038
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subjects Adenosine Deaminase - drug effects
Adenosine Deaminase - pharmacology
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
DNA - metabolism
Enzyme Inhibitors - pharmacology
Humans
Landes
Male
Organogenesis
Plant Extracts - pharmacology
Plant Leaves - chemistry
Prostatic Neoplasms - enzymology
Proteins
Tumor Cells, Cultured
Urtica dioica - chemistry
title Aqueous extract of urtica dioica makes significant inhibition on adenosine deaminase activity in prostate tissue from patients with prostate cancer
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