EFFECTS OF VITAMIN E AND SESAMIN ON HYPERTENSION AND CEREBRAL THROMBOGENESIS IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

SUMMARY The preventive effects of sesamin, a lignan from sesame oil and vitamin E on hypertension and thrombosis were examined using stroke‐prone spontaneously hypertensive rats (SHRSP). Animals at 5 weeks of age were separated into four groups: (i) control group; (ii) vitamin E group, which was giv...

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Veröffentlicht in:Clinical and experimental pharmacology & physiology 2004-12, Vol.31 (s2), p.S24-S26
Hauptverfasser: Noguchi, Takanori, Ikeda, Katsumi, Sasaki, Yasuto, Yamamoto, Junichiro, Yamori, Yukio
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creator Noguchi, Takanori
Ikeda, Katsumi
Sasaki, Yasuto
Yamamoto, Junichiro
Yamori, Yukio
description SUMMARY The preventive effects of sesamin, a lignan from sesame oil and vitamin E on hypertension and thrombosis were examined using stroke‐prone spontaneously hypertensive rats (SHRSP). Animals at 5 weeks of age were separated into four groups: (i) control group; (ii) vitamin E group, which was given 1000 mg alpha‐tocopherol/kg diet; (iii) sesamin group, given 1000 mg sesamin/kg diet; and (iv) vitamin E plus sesamin group, given 1000 mg alpha‐tocopherol plus 1000 mg sesamin/kg diet for 5 weeks from 5 to 10 weeks of age. Resting blood pressure was measured by the tail‐cuff method once weekly. A closed cranial window was created in the right parietal bone of the rat and platelet‐rich thrombi were induced in vivo using a helium‐neon laser technique. The number of laser pulses required for formation of an occlusive thrombus was used as an index of thrombotic tendency. In control rats, systolic blood pressure and the amount of urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) became significantly elevated with age. However, the elevation in blood pressure and 8‐OHdG were significantly suppressed in rats administered vitamin E, sesamin, or vitamin E plus sesamin. At 10 weeks, the number of laser pulses required to induce an occlusive thrombus in arterioles of the control group was significantly lower than in the other groups (P 
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Animals at 5 weeks of age were separated into four groups: (i) control group; (ii) vitamin E group, which was given 1000 mg alpha‐tocopherol/kg diet; (iii) sesamin group, given 1000 mg sesamin/kg diet; and (iv) vitamin E plus sesamin group, given 1000 mg alpha‐tocopherol plus 1000 mg sesamin/kg diet for 5 weeks from 5 to 10 weeks of age. Resting blood pressure was measured by the tail‐cuff method once weekly. A closed cranial window was created in the right parietal bone of the rat and platelet‐rich thrombi were induced in vivo using a helium‐neon laser technique. The number of laser pulses required for formation of an occlusive thrombus was used as an index of thrombotic tendency. In control rats, systolic blood pressure and the amount of urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) became significantly elevated with age. However, the elevation in blood pressure and 8‐OHdG were significantly suppressed in rats administered vitamin E, sesamin, or vitamin E plus sesamin. At 10 weeks, the number of laser pulses required to induce an occlusive thrombus in arterioles of the control group was significantly lower than in the other groups (P &lt; 0.05). 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Animals at 5 weeks of age were separated into four groups: (i) control group; (ii) vitamin E group, which was given 1000 mg alpha‐tocopherol/kg diet; (iii) sesamin group, given 1000 mg sesamin/kg diet; and (iv) vitamin E plus sesamin group, given 1000 mg alpha‐tocopherol plus 1000 mg sesamin/kg diet for 5 weeks from 5 to 10 weeks of age. Resting blood pressure was measured by the tail‐cuff method once weekly. A closed cranial window was created in the right parietal bone of the rat and platelet‐rich thrombi were induced in vivo using a helium‐neon laser technique. The number of laser pulses required for formation of an occlusive thrombus was used as an index of thrombotic tendency. In control rats, systolic blood pressure and the amount of urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) became significantly elevated with age. However, the elevation in blood pressure and 8‐OHdG were significantly suppressed in rats administered vitamin E, sesamin, or vitamin E plus sesamin. At 10 weeks, the number of laser pulses required to induce an occlusive thrombus in arterioles of the control group was significantly lower than in the other groups (P &lt; 0.05). These results indicate that chronic ingestion of vitamin E and sesamin attenuated both elevation in blood pressure, oxidative stress and thrombotic tendency, suggesting that these treatments might be beneficial in the prevention of hypertension and stroke.</description><subject>Animals</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Antioxidants - therapeutic use</subject><subject>blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>cerebral thrombus</subject><subject>Deoxyguanosine - analogs &amp; derivatives</subject><subject>Deoxyguanosine - urine</subject><subject>Dioxoles - therapeutic use</subject><subject>Fibrinolytic Agents - therapeutic use</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - urine</subject><subject>Intracranial Thrombosis - prevention &amp; control</subject><subject>Lignans - therapeutic use</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>sesamin</subject><subject>SHRSP</subject><subject>Stroke - prevention &amp; 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Ikeda, Katsumi ; Sasaki, Yasuto ; Yamamoto, Junichiro ; Yamori, Yukio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2933-d5a4689e3f3c47b3ee4452e469f79171e3a9d1f701a999ad4ad8e7944558fa383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Antioxidants - therapeutic use</topic><topic>blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>cerebral thrombus</topic><topic>Deoxyguanosine - analogs &amp; derivatives</topic><topic>Deoxyguanosine - urine</topic><topic>Dioxoles - therapeutic use</topic><topic>Fibrinolytic Agents - therapeutic use</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - urine</topic><topic>Intracranial Thrombosis - prevention &amp; control</topic><topic>Lignans - therapeutic use</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>sesamin</topic><topic>SHRSP</topic><topic>Stroke - prevention &amp; control</topic><topic>Vitamin E - therapeutic use</topic><topic>vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Noguchi, Takanori</creatorcontrib><creatorcontrib>Ikeda, Katsumi</creatorcontrib><creatorcontrib>Sasaki, Yasuto</creatorcontrib><creatorcontrib>Yamamoto, Junichiro</creatorcontrib><creatorcontrib>Yamori, Yukio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology &amp; physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Noguchi, Takanori</au><au>Ikeda, Katsumi</au><au>Sasaki, Yasuto</au><au>Yamamoto, Junichiro</au><au>Yamori, Yukio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF VITAMIN E AND SESAMIN ON HYPERTENSION AND CEREBRAL THROMBOGENESIS IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS</atitle><jtitle>Clinical and experimental pharmacology &amp; physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2004-12</date><risdate>2004</risdate><volume>31</volume><issue>s2</issue><spage>S24</spage><epage>S26</epage><pages>S24-S26</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY The preventive effects of sesamin, a lignan from sesame oil and vitamin E on hypertension and thrombosis were examined using stroke‐prone spontaneously hypertensive rats (SHRSP). Animals at 5 weeks of age were separated into four groups: (i) control group; (ii) vitamin E group, which was given 1000 mg alpha‐tocopherol/kg diet; (iii) sesamin group, given 1000 mg sesamin/kg diet; and (iv) vitamin E plus sesamin group, given 1000 mg alpha‐tocopherol plus 1000 mg sesamin/kg diet for 5 weeks from 5 to 10 weeks of age. Resting blood pressure was measured by the tail‐cuff method once weekly. A closed cranial window was created in the right parietal bone of the rat and platelet‐rich thrombi were induced in vivo using a helium‐neon laser technique. The number of laser pulses required for formation of an occlusive thrombus was used as an index of thrombotic tendency. In control rats, systolic blood pressure and the amount of urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) became significantly elevated with age. However, the elevation in blood pressure and 8‐OHdG were significantly suppressed in rats administered vitamin E, sesamin, or vitamin E plus sesamin. At 10 weeks, the number of laser pulses required to induce an occlusive thrombus in arterioles of the control group was significantly lower than in the other groups (P &lt; 0.05). These results indicate that chronic ingestion of vitamin E and sesamin attenuated both elevation in blood pressure, oxidative stress and thrombotic tendency, suggesting that these treatments might be beneficial in the prevention of hypertension and stroke.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Pty</pub><pmid>15649279</pmid><doi>10.1111/j.1440-1681.2004.04103.x</doi><tpages>3</tpages></addata></record>
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subjects Animals
Antihypertensive Agents - therapeutic use
Antioxidants - therapeutic use
blood pressure
Blood Pressure - drug effects
cerebral thrombus
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - urine
Dioxoles - therapeutic use
Fibrinolytic Agents - therapeutic use
Hypertension - drug therapy
Hypertension - physiopathology
Hypertension - urine
Intracranial Thrombosis - prevention & control
Lignans - therapeutic use
Rats
Rats, Inbred SHR
sesamin
SHRSP
Stroke - prevention & control
Vitamin E - therapeutic use
vitamin E
title EFFECTS OF VITAMIN E AND SESAMIN ON HYPERTENSION AND CEREBRAL THROMBOGENESIS IN STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS
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