Serum pro-hepcidin levels in term and preterm newborns with sepsis
Background: An iron regulatory peptide hormone, hepcidin, is also part of the innate immune system and is strongly induced during infections and inflammation. The aim of the present study was to determine serum levels of the 60 aa pro‐hormone form of hepcidin (pro‐hepcidin) in full‐term and preterm...
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| Veröffentlicht in: | Pediatrics international 2009-04, Vol.51 (2), p.289-292 |
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| creator | Yapakçı, Ece Tarcan, Aylin Çelik, Banu Özbek, Namık Gürakan, Berkan |
| description | Background: An iron regulatory peptide hormone, hepcidin, is also part of the innate immune system and is strongly induced during infections and inflammation. The aim of the present study was to determine serum levels of the 60 aa pro‐hormone form of hepcidin (pro‐hepcidin) in full‐term and preterm newborns with sepsis and to determine the possible relationships between pro‐hepcidin levels and serum iron and complete blood count parameters.
Methods: Fifteen preterm newborns with sepsis, 17 healthy preterm, six full‐term newborns with sepsis and 16 healthy full‐term newborns were included the study. Blood samples were collected from patients with sepsis at the time of clinical diagnosis. Each blood sample was analyzed for complete blood count, serum iron and ferritin concentrations, iron‐binding capacity, and pro‐hepcidin level.
Results: The mean serum pro‐hepcidin level (mean ± SD) in preterm neonates with sepsis and in healthy preterm newborns was 565.4 ± 519.5 ng/mL and 279.8 ± 227.6 ng/mL, respectively (P |
| doi_str_mv | 10.1111/j.1442-200X.2008.02688.x |
| format | Article |
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Methods: Fifteen preterm newborns with sepsis, 17 healthy preterm, six full‐term newborns with sepsis and 16 healthy full‐term newborns were included the study. Blood samples were collected from patients with sepsis at the time of clinical diagnosis. Each blood sample was analyzed for complete blood count, serum iron and ferritin concentrations, iron‐binding capacity, and pro‐hepcidin level.
Results: The mean serum pro‐hepcidin level (mean ± SD) in preterm neonates with sepsis and in healthy preterm newborns was 565.4 ± 519.5 ng/mL and 279.8 ± 227.6 ng/mL, respectively (P < 0.05). The mean serum pro‐hepcidin level in full‐term newborns with sepsis and in healthy full‐term neonates was 981.4 ± 415.4 ng/mL and 482 ± 371.9 ng/mL, respectively (P < 0.05). Although the mean serum ferritin levels in the two groups with sepsis were higher when compared with the healthy groups, the difference was not statistically significant in full‐term newborns. No statistically significant correlations were found between serum pro‐hepcidin levels and any other parameters in each group.
Conclusions: Serum pro‐hepcidin levels were higher in newborns with sepsis (either premature or full‐term) than they were in healthy newborns at the time of clinical diagnosis.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/j.1442-200X.2008.02688.x</identifier><identifier>PMID: 19405934</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Antimicrobial Cationic Peptides - blood ; Babies ; Blood Cell Count ; Comparative studies ; Diagnostic tests ; Female ; Ferritins - blood ; hepcidin ; Hepcidins ; Hormones ; Humans ; Immune system ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - blood ; Iron - blood ; Male ; newborn ; Pediatrics ; Premature birth ; pro-hepcidin ; Sepsis ; Sepsis - blood</subject><ispartof>Pediatrics international, 2009-04, Vol.51 (2), p.289-292</ispartof><rights>2008 Japan Pediatric Society</rights><rights>2009 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5168-bc10a2c309a8526a572517ac7a044208fb168249ce92791bcf0b834b20f81a13</citedby><cites>FETCH-LOGICAL-c5168-bc10a2c309a8526a572517ac7a044208fb168249ce92791bcf0b834b20f81a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1442-200X.2008.02688.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1442-200X.2008.02688.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19405934$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yapakçı, Ece</creatorcontrib><creatorcontrib>Tarcan, Aylin</creatorcontrib><creatorcontrib>Çelik, Banu</creatorcontrib><creatorcontrib>Özbek, Namık</creatorcontrib><creatorcontrib>Gürakan, Berkan</creatorcontrib><title>Serum pro-hepcidin levels in term and preterm newborns with sepsis</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background: An iron regulatory peptide hormone, hepcidin, is also part of the innate immune system and is strongly induced during infections and inflammation. The aim of the present study was to determine serum levels of the 60 aa pro‐hormone form of hepcidin (pro‐hepcidin) in full‐term and preterm newborns with sepsis and to determine the possible relationships between pro‐hepcidin levels and serum iron and complete blood count parameters.
Methods: Fifteen preterm newborns with sepsis, 17 healthy preterm, six full‐term newborns with sepsis and 16 healthy full‐term newborns were included the study. Blood samples were collected from patients with sepsis at the time of clinical diagnosis. Each blood sample was analyzed for complete blood count, serum iron and ferritin concentrations, iron‐binding capacity, and pro‐hepcidin level.
Results: The mean serum pro‐hepcidin level (mean ± SD) in preterm neonates with sepsis and in healthy preterm newborns was 565.4 ± 519.5 ng/mL and 279.8 ± 227.6 ng/mL, respectively (P < 0.05). The mean serum pro‐hepcidin level in full‐term newborns with sepsis and in healthy full‐term neonates was 981.4 ± 415.4 ng/mL and 482 ± 371.9 ng/mL, respectively (P < 0.05). Although the mean serum ferritin levels in the two groups with sepsis were higher when compared with the healthy groups, the difference was not statistically significant in full‐term newborns. No statistically significant correlations were found between serum pro‐hepcidin levels and any other parameters in each group.
Conclusions: Serum pro‐hepcidin levels were higher in newborns with sepsis (either premature or full‐term) than they were in healthy newborns at the time of clinical diagnosis.</description><subject>Antimicrobial Cationic Peptides - blood</subject><subject>Babies</subject><subject>Blood Cell Count</subject><subject>Comparative studies</subject><subject>Diagnostic tests</subject><subject>Female</subject><subject>Ferritins - blood</subject><subject>hepcidin</subject><subject>Hepcidins</subject><subject>Hormones</subject><subject>Humans</subject><subject>Immune system</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Iron - blood</subject><subject>Male</subject><subject>newborn</subject><subject>Pediatrics</subject><subject>Premature birth</subject><subject>pro-hepcidin</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUlP5DAQhS0EYv8LKJoDt4TyljgHDsCwCQRIIIG4WI67ItJk6bE7dPPvcegWSHMBH8pPqu-Vys-ERBQSGs7BOKFCsJgBPCWhqARYqlQyXyGbX43VoDlTsYI02yBb3o8hkJkS62SD5gJkzsUmOb5H1zfRxHXxC05sNaraqMY3rH0U1BRdE5l2FPr4qVucFZ1rfTSrpi-Rx4mv_A5ZK03tcXd5b5OHs9OHk4v4-vb88uToOraSpiouLAXDLIfcKMlSIzMmaWZsZiCsDKosAsVEbjFnWU4LW0KhuCgYlIoayrfJ_mJs2PVfj36qm8pbrGvTYtd7nWaMpsH_I8hAipQKFsA__4HjrndteINmlEnGAQZILSDrOu8dlnriqsa4d01BD5-hx3rIXA-ZD0Xpz8_Q82DdW87viwZH38Zl-gE4XACzqsb3Xw_Wd6d_BxX88cJf-SnOv_zGvYY0eCb14825vuIgzu6eQUv-AVyspSY</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Yapakçı, Ece</creator><creator>Tarcan, Aylin</creator><creator>Çelik, Banu</creator><creator>Özbek, Namık</creator><creator>Gürakan, Berkan</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200904</creationdate><title>Serum pro-hepcidin levels in term and preterm newborns with sepsis</title><author>Yapakçı, Ece ; Tarcan, Aylin ; Çelik, Banu ; Özbek, Namık ; Gürakan, Berkan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5168-bc10a2c309a8526a572517ac7a044208fb168249ce92791bcf0b834b20f81a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Antimicrobial Cationic Peptides - blood</topic><topic>Babies</topic><topic>Blood Cell Count</topic><topic>Comparative studies</topic><topic>Diagnostic tests</topic><topic>Female</topic><topic>Ferritins - blood</topic><topic>hepcidin</topic><topic>Hepcidins</topic><topic>Hormones</topic><topic>Humans</topic><topic>Immune system</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Iron - blood</topic><topic>Male</topic><topic>newborn</topic><topic>Pediatrics</topic><topic>Premature birth</topic><topic>pro-hepcidin</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yapakçı, Ece</creatorcontrib><creatorcontrib>Tarcan, Aylin</creatorcontrib><creatorcontrib>Çelik, Banu</creatorcontrib><creatorcontrib>Özbek, Namık</creatorcontrib><creatorcontrib>Gürakan, Berkan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yapakçı, Ece</au><au>Tarcan, Aylin</au><au>Çelik, Banu</au><au>Özbek, Namık</au><au>Gürakan, Berkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum pro-hepcidin levels in term and preterm newborns with sepsis</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2009-04</date><risdate>2009</risdate><volume>51</volume><issue>2</issue><spage>289</spage><epage>292</epage><pages>289-292</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background: An iron regulatory peptide hormone, hepcidin, is also part of the innate immune system and is strongly induced during infections and inflammation. The aim of the present study was to determine serum levels of the 60 aa pro‐hormone form of hepcidin (pro‐hepcidin) in full‐term and preterm newborns with sepsis and to determine the possible relationships between pro‐hepcidin levels and serum iron and complete blood count parameters.
Methods: Fifteen preterm newborns with sepsis, 17 healthy preterm, six full‐term newborns with sepsis and 16 healthy full‐term newborns were included the study. Blood samples were collected from patients with sepsis at the time of clinical diagnosis. Each blood sample was analyzed for complete blood count, serum iron and ferritin concentrations, iron‐binding capacity, and pro‐hepcidin level.
Results: The mean serum pro‐hepcidin level (mean ± SD) in preterm neonates with sepsis and in healthy preterm newborns was 565.4 ± 519.5 ng/mL and 279.8 ± 227.6 ng/mL, respectively (P < 0.05). The mean serum pro‐hepcidin level in full‐term newborns with sepsis and in healthy full‐term neonates was 981.4 ± 415.4 ng/mL and 482 ± 371.9 ng/mL, respectively (P < 0.05). Although the mean serum ferritin levels in the two groups with sepsis were higher when compared with the healthy groups, the difference was not statistically significant in full‐term newborns. No statistically significant correlations were found between serum pro‐hepcidin levels and any other parameters in each group.
Conclusions: Serum pro‐hepcidin levels were higher in newborns with sepsis (either premature or full‐term) than they were in healthy newborns at the time of clinical diagnosis.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19405934</pmid><doi>10.1111/j.1442-200X.2008.02688.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Antimicrobial Cationic Peptides - blood Babies Blood Cell Count Comparative studies Diagnostic tests Female Ferritins - blood hepcidin Hepcidins Hormones Humans Immune system Infant, Newborn Infant, Premature Infant, Premature, Diseases - blood Iron - blood Male newborn Pediatrics Premature birth pro-hepcidin Sepsis Sepsis - blood |
| title | Serum pro-hepcidin levels in term and preterm newborns with sepsis |
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