Opposite Changes in Glutamatergic and GABAergic Transmission Underlie the Diffuse Hyperexcitability of Synapsin I–Deficient Cortical Networks

Synapsins (Syns) are synaptic vesicle (SV) phosphoproteins that play a role in synaptic transmission and plasticity. Mutation of the SYN1 gene results in an epileptic phenotype in mouse and man, implicating SynI in the control of network excitability. We used microelectrode array and patch-clamp rec...

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Veröffentlicht in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2009-06, Vol.19 (6), p.1422-1439
Hauptverfasser: Chiappalone, Michela, Casagrande, Silvia, Tedesco, Mariateresa, Valtorta, Flavia, Baldelli, Pietro, Martinoia, Sergio, Benfenati, Fabio
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Sprache:eng
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