Humanization of a chicken anti-IL-12 monoclonal antibody

Chicken anti-IL-12 monoclonal antibodies were isolated by phage display using spleen cells from a chicken immunized with human and mouse IL-12 as a source for library construction. One of the chicken monoclonal antibodies, DD2, exhibited binding to both human and mouse IL-12 in the single-chain Fv f...

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Veröffentlicht in:	Journal of immunological methods 2004-12, Vol.295 (1), p.9-19
Hauptverfasser:	Tsurushita, Naoya, Park, Minha, Pakabunto, Kanokwan, Ong, Kelly, Avdalovic, Anamarija, Fu, Helen, Jia, Audrey, Vásquez, Max, Kumar, Shankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Antibodies, Monoclonal - isolation & purification Antibody Affinity - immunology Antibody engineering Antibody Specificity - immunology Biological and medical sciences Chickens - immunology Cross-reactive antibody Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunoglobulin Variable Region - chemistry Immunoglobulin Variable Region - genetics Immunoglobulin Variable Region - immunology Interleukin-12 - immunology Models, Molecular Molecular immunology Molecular Sequence Data Peptide Library Phage display Techniques Tolerance
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