Loss of hPot1 Function Leads to Telomere Instability and a cut-like Phenotype

The human telomere binding protein hPot1 binds to the most distal single-stranded extension of telomeric DNA in vitro, and probably in vivo [1, 2], as well as associating with the double-stranded telomeric DNA binding proteins TRF1 and TRF2 through the bridging proteins PTOP (also known as PIP1 or T...

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Veröffentlicht in:	Current biology 2004-12, Vol.14 (24), p.2264-2270
Hauptverfasser:	Veldman, Timothy, Etheridge, Katherine T., Counter, Christopher M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Chromosomal Instability - genetics Chromosomal Instability - physiology Chromosome Segregation - physiology DNA - metabolism DNA Primers HeLa Cells Humans Immunoblotting Micronuclei, Chromosome-Defective Phenotype Reverse Transcriptase Polymerase Chain Reaction Saccharomyces cerevisiae Schizosaccharomyces pombe Telomere - genetics Telomere - physiology Telomere-Binding Proteins - metabolism Telomere-Binding Proteins - physiology Telomeric Repeat Binding Protein 1 - metabolism Telomeric Repeat Binding Protein 2 - metabolism
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