Improved growth response of antibody/receptor chimera attained by the engineering of transmembrane domain

Structure-based design of antibody/cytokine receptor chimeras has permitted a growth signal transduction in response to non-natural ligands such as fluorescein-conjugated BSA as mimicry of cytokine–cytokine receptor systems. However, while tight on/off regulation is observed in the natural cytokine...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2004-10, Vol.17 (10), p.715-719
Hauptverfasser:	Kawahara, Masahiro, Ogo, Yuko, Ueda, Hiroshi, Nagamune, Teruyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - chemistry Antibodies - genetics Antibodies - metabolism antibody Cell Division - drug effects Cell Line chimeric receptor cytokine receptor Humans In Vitro Techniques Mice Mutation Protein Engineering Protein Structure, Tertiary Receptors, Cytokine - chemistry Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology transmembrane domain
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