M1 and M2a Polarization of Human Monocyte-Derived Macrophages Inhibits HIV-1 Replication by Distinct Mechanisms

The capacity of macrophages to support productive HIV-1 infection is known to be modulated by cytokines and other extracellular stimuli. In this study, we demonstrate that cytokine-induced polarization of human monocyte-derived macrophage (MDM) into either classical (M1) or alternatively activated (...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-05, Vol.182 (10), p.6237-6246
Hauptverfasser:	Cassol, Edana, Cassetta, Luca, Rizzi, Chiara, Alfano, Massimo, Poli, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4 Antigens - biosynthesis CD4 Antigens - immunology Cell Differentiation - immunology Cytokines - biosynthesis Cytokines - immunology Enzyme-Linked Immunosorbent Assay Flow Cytometry HIV Infections - immunology HIV Infections - virology HIV-1 - physiology Humans Interferon-gamma - immunology Macrophage Activation - immunology Macrophages - cytology Macrophages - immunology Macrophages - virology Receptors, CCR5 - biosynthesis Receptors, CCR5 - immunology Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - immunology Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha - immunology Virus Replication - physiology
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