Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging
A dual-wavelength laser speckle contrast imaging technique (DW-LSCI) is presented for simultaneous imaging of cerebral blood flow and hemoglobin oxygenation changes at high spatiotemporal resolutions. Experimental validation was performed using a rat transient forebrain ischemia model. The results s...
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| Veröffentlicht in: | Optics letters 2009-05, Vol.34 (9), p.1480-1482 |
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| container_title | Optics letters |
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| creator | Luo, Zhongchi Yuan, Zhijia Pan, Yingtian Du, Congwu |
| description | A dual-wavelength laser speckle contrast imaging technique (DW-LSCI) is presented for simultaneous imaging of cerebral blood flow and hemoglobin oxygenation changes at high spatiotemporal resolutions. Experimental validation was performed using a rat transient forebrain ischemia model. The results showed that DW-LSCI was able to track detailed hemodynamic and metabolic changes induced by ischemia, i.e., decreased oxy- and total hemoglobin concentrations and blood flow as well as increased deoxy-hemoglobin concentration in the downstream regions, thus allowing us to distinguish cerebral arterial and venous flows. Simultaneous cerebral blood flow and oxygenation imaging at high spatiotemporal resolutions is crucial to the understanding of neural process and brain functions. |
| doi_str_mv | 10.1364/ol.34.001480 |
| format | Article |
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Experimental validation was performed using a rat transient forebrain ischemia model. The results showed that DW-LSCI was able to track detailed hemodynamic and metabolic changes induced by ischemia, i.e., decreased oxy- and total hemoglobin concentrations and blood flow as well as increased deoxy-hemoglobin concentration in the downstream regions, thus allowing us to distinguish cerebral arterial and venous flows. Simultaneous cerebral blood flow and oxygenation imaging at high spatiotemporal resolutions is crucial to the understanding of neural process and brain functions.</description><identifier>ISSN: 0146-9592</identifier><identifier>EISSN: 1539-4794</identifier><identifier>DOI: 10.1364/ol.34.001480</identifier><identifier>PMID: 19412312</identifier><identifier>CODEN: OPLEDP</identifier><language>eng</language><publisher>Washington, DC: Optical Society of America</publisher><subject>Animals ; Biological and medical sciences ; Blood Volume ; Brain Ischemia - blood ; Brain Ischemia - physiopathology ; Cerebral Cortex - blood supply ; Cerebral Cortex - physiopathology ; Cerebrovascular Circulation ; Diagnostic Imaging ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; Fundamental areas of phenomenology (including applications) ; General aspects, investigation technics, apparatus ; Hemodynamics ; Imaging and optical processing ; Infrared Rays ; Lasers ; Optics ; Oxygen - blood ; Oxyhemoglobins - metabolism ; Physics ; Rats ; Speckle and moire patterns ; Time Factors ; Tissues, organs and organisms biophysics</subject><ispartof>Optics letters, 2009-05, Vol.34 (9), p.1480-1482</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-e202dba897d124bf8118e0155f619af722458cc58402acfb1de4141848ceb2b3</citedby><cites>FETCH-LOGICAL-c428t-e202dba897d124bf8118e0155f619af722458cc58402acfb1de4141848ceb2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,3247,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21506809$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19412312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Zhongchi</creatorcontrib><creatorcontrib>Yuan, Zhijia</creatorcontrib><creatorcontrib>Pan, Yingtian</creatorcontrib><creatorcontrib>Du, Congwu</creatorcontrib><title>Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging</title><title>Optics letters</title><addtitle>Opt Lett</addtitle><description>A dual-wavelength laser speckle contrast imaging technique (DW-LSCI) is presented for simultaneous imaging of cerebral blood flow and hemoglobin oxygenation changes at high spatiotemporal resolutions. Experimental validation was performed using a rat transient forebrain ischemia model. The results showed that DW-LSCI was able to track detailed hemodynamic and metabolic changes induced by ischemia, i.e., decreased oxy- and total hemoglobin concentrations and blood flow as well as increased deoxy-hemoglobin concentration in the downstream regions, thus allowing us to distinguish cerebral arterial and venous flows. Simultaneous cerebral blood flow and oxygenation imaging at high spatiotemporal resolutions is crucial to the understanding of neural process and brain functions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Volume</subject><subject>Brain Ischemia - blood</subject><subject>Brain Ischemia - physiopathology</subject><subject>Cerebral Cortex - blood supply</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cerebrovascular Circulation</subject><subject>Diagnostic Imaging</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental areas of phenomenology (including applications)</subject><subject>General aspects, investigation technics, apparatus</subject><subject>Hemodynamics</subject><subject>Imaging and optical processing</subject><subject>Infrared Rays</subject><subject>Lasers</subject><subject>Optics</subject><subject>Oxygen - blood</subject><subject>Oxyhemoglobins - metabolism</subject><subject>Physics</subject><subject>Rats</subject><subject>Speckle and moire patterns</subject><subject>Time Factors</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0146-9592</issn><issn>1539-4794</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUuP1DAQhC0EYoeFG2fkC5w2g19JnCNa8ZJG2gN7jzp2J2Nw7MFOdpl_ws_Foxng1FLrq-5SFSGvOdty2aj30W-l2jLGlWZPyIbXsqtU26mnZFN2TdXVnbgiL3L-zhhrWimfkyveKS4kFxvy-5ubV79AwLhm6maYXJhoHKmJaXEGPN3jHO0xwOxMphAsHXyMlsZfxwkDLC4GavYQJqR2TSexwYRDKkqXTRE7oGs-7e0KvnqEB_QYpmVPPWRMNB_Q_PBY_oUlQV7-enhJno3gM766zGty_-nj_e2Xanf3-evth11llNBLhYIJO4DuWsuFGkbNuUbG63pseAdjK4SqtTG1VkyAGQduUXHFtdIGBzHIa_LufPaQ4s8V89LPxTZ6f06kb1rBuG5kAW_OoEkx54Rjf0jFajr2nPWnIvq7XS9Vfy6i4G8ud9dhRvsfviRfgLcXAHKJeUwQjMv_OMFr1mjWyT8JfZRU</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Luo, Zhongchi</creator><creator>Yuan, Zhijia</creator><creator>Pan, Yingtian</creator><creator>Du, Congwu</creator><general>Optical Society of America</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090501</creationdate><title>Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging</title><author>Luo, Zhongchi ; Yuan, Zhijia ; Pan, Yingtian ; Du, Congwu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-e202dba897d124bf8118e0155f619af722458cc58402acfb1de4141848ceb2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Volume</topic><topic>Brain Ischemia - blood</topic><topic>Brain Ischemia - physiopathology</topic><topic>Cerebral Cortex - blood supply</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cerebrovascular Circulation</topic><topic>Diagnostic Imaging</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental areas of phenomenology (including applications)</topic><topic>General aspects, investigation technics, apparatus</topic><topic>Hemodynamics</topic><topic>Imaging and optical processing</topic><topic>Infrared Rays</topic><topic>Lasers</topic><topic>Optics</topic><topic>Oxygen - blood</topic><topic>Oxyhemoglobins - metabolism</topic><topic>Physics</topic><topic>Rats</topic><topic>Speckle and moire patterns</topic><topic>Time Factors</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Zhongchi</creatorcontrib><creatorcontrib>Yuan, Zhijia</creatorcontrib><creatorcontrib>Pan, Yingtian</creatorcontrib><creatorcontrib>Du, Congwu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Optics letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Zhongchi</au><au>Yuan, Zhijia</au><au>Pan, Yingtian</au><au>Du, Congwu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging</atitle><jtitle>Optics letters</jtitle><addtitle>Opt Lett</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>34</volume><issue>9</issue><spage>1480</spage><epage>1482</epage><pages>1480-1482</pages><issn>0146-9592</issn><eissn>1539-4794</eissn><coden>OPLEDP</coden><abstract>A dual-wavelength laser speckle contrast imaging technique (DW-LSCI) is presented for simultaneous imaging of cerebral blood flow and hemoglobin oxygenation changes at high spatiotemporal resolutions. Experimental validation was performed using a rat transient forebrain ischemia model. The results showed that DW-LSCI was able to track detailed hemodynamic and metabolic changes induced by ischemia, i.e., decreased oxy- and total hemoglobin concentrations and blood flow as well as increased deoxy-hemoglobin concentration in the downstream regions, thus allowing us to distinguish cerebral arterial and venous flows. Simultaneous cerebral blood flow and oxygenation imaging at high spatiotemporal resolutions is crucial to the understanding of neural process and brain functions.</abstract><cop>Washington, DC</cop><pub>Optical Society of America</pub><pmid>19412312</pmid><doi>10.1364/ol.34.001480</doi><tpages>3</tpages></addata></record> |
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| ispartof | Optics letters, 2009-05, Vol.34 (9), p.1480-1482 |
| issn | 0146-9592 1539-4794 |
| language | eng |
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| source | MEDLINE; Optica Publishing Group Journals |
| subjects | Animals Biological and medical sciences Blood Volume Brain Ischemia - blood Brain Ischemia - physiopathology Cerebral Cortex - blood supply Cerebral Cortex - physiopathology Cerebrovascular Circulation Diagnostic Imaging Exact sciences and technology Fundamental and applied biological sciences. Psychology Fundamental areas of phenomenology (including applications) General aspects, investigation technics, apparatus Hemodynamics Imaging and optical processing Infrared Rays Lasers Optics Oxygen - blood Oxyhemoglobins - metabolism Physics Rats Speckle and moire patterns Time Factors Tissues, organs and organisms biophysics |
| title | Simultaneous imaging of cortical hemodynamics and blood oxygenation change during cerebral ischemia using dual-wavelength laser speckle contrast imaging |
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