Is the etiology of eosinophilic esophagitis in adults a response to allergy or reflux injury? Study of cellular proliferation markers

SUMMARY Recent research suggests that allergy may be the key factor in the etiology of eosinophilic esophagitis (EE); however, historically, the condition was hypothesized as related to reflux injury to the esophageal mucosa. We studied this hypothesis by comparing markers of inflammation and cellul...

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Veröffentlicht in:	Diseases of the esophagus 2009-05, Vol.22 (3), p.249-255
Hauptverfasser:	Lewis, C. J., Lamb, C. A., Kanakala, V., Pritchard, S., Armstrong, G. R., Attwood, S. E. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged allergy Antibodies, Monoclonal Apoptosis Biomarkers - metabolism Biopsy Case-Control Studies Cell Proliferation Cyclooxygenase 2 - metabolism Eosinophilia - etiology Eosinophilia - metabolism eosinophils esophagitis Esophagitis - etiology Esophagitis - metabolism Esophagus - pathology Female Gastroesophageal Reflux - metabolism Humans Immunohistochemistry inflammation Ki-67 Antigen - immunology Ki-67 Antigen - metabolism Male Middle Aged Mucous Membrane - metabolism Proto-Oncogene Proteins c-bcl-2 - immunology Proto-Oncogene Proteins c-bcl-2 - metabolism reflux
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