Normal organ standard uptake values in carbon-11 acetate PET imaging
OBJECTIVEThe goal of this study was to determine normal standard uptake values of carbon-11 (C) acetate in healthy organs. By accurately determining the range of physiologic activity, abnormal focal or diffuse C-acetate activity can be more accurately assessed and thus improve the sensitivity and sp...
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| Veröffentlicht in: | Nuclear medicine communications 2009-06, Vol.30 (6), p.462-465 |
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| creator | Song, Won S Nielson, Brett R Banks, Kevin P Bradley, Yong C |
| description | OBJECTIVEThe goal of this study was to determine normal standard uptake values of carbon-11 (C) acetate in healthy organs. By accurately determining the range of physiologic activity, abnormal focal or diffuse C-acetate activity can be more accurately assessed and thus improve the sensitivity and specificity of this emerging diagnostic PET agent.
METHODSWe reviewed all 55 patients (mean age±SD 64.8±10.8, age range 35–88 years) who underwent C-acetate PET/computed tomography at our institution from 2005 to 2007. Regions of interest were drawn in organs that were devoid of clinical or imaging evidence of disease. The maximum standard uptake value for each region was calculated and analyzed for mean, standard deviation, and 95% confidence intervals.
RESULTSThe results are presented as average maximum standard uptake value±1 SD with the pancreas, liver, spleen and salivary glands showing the greatest C-acetate avidity. A review of the literature shows our results to be similar to those published earlier.
CONCLUSIONAccurate knowledge of normal biodistribution and standardized uptake values will provide the foundation for assessing focal or diffuse organ disease while using this PET agent. |
| doi_str_mv | 10.1097/MNM.0b013e32832aa7ce |
| format | Article |
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METHODSWe reviewed all 55 patients (mean age±SD 64.8±10.8, age range 35–88 years) who underwent C-acetate PET/computed tomography at our institution from 2005 to 2007. Regions of interest were drawn in organs that were devoid of clinical or imaging evidence of disease. The maximum standard uptake value for each region was calculated and analyzed for mean, standard deviation, and 95% confidence intervals.
RESULTSThe results are presented as average maximum standard uptake value±1 SD with the pancreas, liver, spleen and salivary glands showing the greatest C-acetate avidity. A review of the literature shows our results to be similar to those published earlier.
CONCLUSIONAccurate knowledge of normal biodistribution and standardized uptake values will provide the foundation for assessing focal or diffuse organ disease while using this PET agent.</description><identifier>ISSN: 0143-3636</identifier><identifier>EISSN: 1473-5628</identifier><identifier>DOI: 10.1097/MNM.0b013e32832aa7ce</identifier><identifier>PMID: 19357549</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Acetates - chemistry ; Acetates - pharmacokinetics ; Adult ; Aged ; Aged, 80 and over ; Carbon Radioisotopes - pharmacokinetics ; Carcinoma, Hepatocellular - diagnostic imaging ; Carcinoma, Hepatocellular - metabolism ; Diffusion ; Female ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography - standards ; Radiopharmaceuticals - chemistry ; Radiopharmaceuticals - pharmacokinetics ; Reference Values ; Sensitivity and Specificity ; Tomography, X-Ray Computed</subject><ispartof>Nuclear medicine communications, 2009-06, Vol.30 (6), p.462-465</ispartof><rights>2009 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354e-ba651dd3e3f6ee5f7f7779c2377b078ffb2d5fd6088f0edabc39b4f1959d214e3</citedby><cites>FETCH-LOGICAL-c354e-ba651dd3e3f6ee5f7f7779c2377b078ffb2d5fd6088f0edabc39b4f1959d214e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19357549$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Won S</creatorcontrib><creatorcontrib>Nielson, Brett R</creatorcontrib><creatorcontrib>Banks, Kevin P</creatorcontrib><creatorcontrib>Bradley, Yong C</creatorcontrib><title>Normal organ standard uptake values in carbon-11 acetate PET imaging</title><title>Nuclear medicine communications</title><addtitle>Nucl Med Commun</addtitle><description>OBJECTIVEThe goal of this study was to determine normal standard uptake values of carbon-11 (C) acetate in healthy organs. By accurately determining the range of physiologic activity, abnormal focal or diffuse C-acetate activity can be more accurately assessed and thus improve the sensitivity and specificity of this emerging diagnostic PET agent.
METHODSWe reviewed all 55 patients (mean age±SD 64.8±10.8, age range 35–88 years) who underwent C-acetate PET/computed tomography at our institution from 2005 to 2007. Regions of interest were drawn in organs that were devoid of clinical or imaging evidence of disease. The maximum standard uptake value for each region was calculated and analyzed for mean, standard deviation, and 95% confidence intervals.
RESULTSThe results are presented as average maximum standard uptake value±1 SD with the pancreas, liver, spleen and salivary glands showing the greatest C-acetate avidity. A review of the literature shows our results to be similar to those published earlier.
CONCLUSIONAccurate knowledge of normal biodistribution and standardized uptake values will provide the foundation for assessing focal or diffuse organ disease while using this PET agent.</description><subject>Acetates - chemistry</subject><subject>Acetates - pharmacokinetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carbon Radioisotopes - pharmacokinetics</subject><subject>Carcinoma, Hepatocellular - diagnostic imaging</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Diffusion</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography - standards</subject><subject>Radiopharmaceuticals - chemistry</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, X-Ray Computed</subject><issn>0143-3636</issn><issn>1473-5628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAURS0EoqXwDxDyxJZix3GcjKiUD4kWhjJHz_ZzG5omxU6o-PcEtRISA9Ndzr26OoRccjbmLFc3s_lszDTjAkWciRhAGTwiQ54oEck0zo7JkPFERCIV6YCchfDOGMtEqk7JgOdCKpnkQ3I3b_wGKtr4JdQ0tFBb8JZ22xbWSD-h6jDQsqYGvG7qiHMKBltokb5OF7TcwLKsl-fkxEEV8OKQI_J2P11MHqPnl4enye1zZIRMMNKQSm5tf9iliNIpp5TKTSyU0kxlzunYSmdTlmWOoQVtRK4Tx3OZ25gnKEbker-79c1Hf6wtNmUwWFVQY9OFIlUxY4rLHkz2oPFNCB5dsfX9V_9VcFb82Ct6e8Vfe33t6rDf6Q3a39JBVw9ke2DXVC36sK66HfpihVC1q_-3vwE0wX7i</recordid><startdate>200906</startdate><enddate>200906</enddate><creator>Song, Won S</creator><creator>Nielson, Brett R</creator><creator>Banks, Kevin P</creator><creator>Bradley, Yong C</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200906</creationdate><title>Normal organ standard uptake values in carbon-11 acetate PET imaging</title><author>Song, Won S ; Nielson, Brett R ; Banks, Kevin P ; Bradley, Yong C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354e-ba651dd3e3f6ee5f7f7779c2377b078ffb2d5fd6088f0edabc39b4f1959d214e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetates - chemistry</topic><topic>Acetates - pharmacokinetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carbon Radioisotopes - pharmacokinetics</topic><topic>Carcinoma, Hepatocellular - diagnostic imaging</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Diffusion</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography - standards</topic><topic>Radiopharmaceuticals - chemistry</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Won S</creatorcontrib><creatorcontrib>Nielson, Brett R</creatorcontrib><creatorcontrib>Banks, Kevin P</creatorcontrib><creatorcontrib>Bradley, Yong C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Won S</au><au>Nielson, Brett R</au><au>Banks, Kevin P</au><au>Bradley, Yong C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Normal organ standard uptake values in carbon-11 acetate PET imaging</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>2009-06</date><risdate>2009</risdate><volume>30</volume><issue>6</issue><spage>462</spage><epage>465</epage><pages>462-465</pages><issn>0143-3636</issn><eissn>1473-5628</eissn><abstract>OBJECTIVEThe goal of this study was to determine normal standard uptake values of carbon-11 (C) acetate in healthy organs. By accurately determining the range of physiologic activity, abnormal focal or diffuse C-acetate activity can be more accurately assessed and thus improve the sensitivity and specificity of this emerging diagnostic PET agent.
METHODSWe reviewed all 55 patients (mean age±SD 64.8±10.8, age range 35–88 years) who underwent C-acetate PET/computed tomography at our institution from 2005 to 2007. Regions of interest were drawn in organs that were devoid of clinical or imaging evidence of disease. The maximum standard uptake value for each region was calculated and analyzed for mean, standard deviation, and 95% confidence intervals.
RESULTSThe results are presented as average maximum standard uptake value±1 SD with the pancreas, liver, spleen and salivary glands showing the greatest C-acetate avidity. A review of the literature shows our results to be similar to those published earlier.
CONCLUSIONAccurate knowledge of normal biodistribution and standardized uptake values will provide the foundation for assessing focal or diffuse organ disease while using this PET agent.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>19357549</pmid><doi>10.1097/MNM.0b013e32832aa7ce</doi><tpages>4</tpages></addata></record> |
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| ispartof | Nuclear medicine communications, 2009-06, Vol.30 (6), p.462-465 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acetates - chemistry Acetates - pharmacokinetics Adult Aged Aged, 80 and over Carbon Radioisotopes - pharmacokinetics Carcinoma, Hepatocellular - diagnostic imaging Carcinoma, Hepatocellular - metabolism Diffusion Female Humans Male Middle Aged Positron-Emission Tomography - standards Radiopharmaceuticals - chemistry Radiopharmaceuticals - pharmacokinetics Reference Values Sensitivity and Specificity Tomography, X-Ray Computed |
| title | Normal organ standard uptake values in carbon-11 acetate PET imaging |
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