Intracoronary Angiotensin II causes inotropic and vascular effects via different paracrine mechanisms

We hypothesized that Angiotensin II (Ang II), like other circulating hormones, acts exclusively intravascularly. To activate or block solely intravascular Ang II receptors, Ang II and its peptide receptor blocker saralasin (Sar) were covalently coupled to a inert polymer (POL, MW >4000 kD) formin...

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Veröffentlicht in:	Vascular pharmacology 2004-05, Vol.41 (4), p.147-158
Hauptverfasser:	Castillo-Hernandez, Jesus R., Rubio-Gayosso, Ivan, Sada-Ovalle, Isabel, Garcia-Vazquez, Alicia, Ceballos, Guillermo, Rubio, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - administration & dosage Animals ATP and thromboxane release Cardiotonic Agents - administration & dosage Coronary vascular endothelial heterogeneity Coronary Vessels - drug effects Coronary Vessels - physiology Dose-Response Relationship, Drug In Vitro Techniques Intravascular Angiotensin II receptors Male Myocardial Contraction - drug effects Myocardial Contraction - physiology Paracrine Communication - drug effects Paracrine Communication - physiology Rats
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