Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor—Part II
Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of t...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2009-05, Vol.19 (10), p.2627-2629 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Kamath, Vivekanand P. Xue, Jie Juarez-Brambila, Jesus J. |
| description | Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (
2–
4).
Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (
2–
4). |
| doi_str_mv | 10.1016/j.bmcl.2009.04.018 |
| format | Article |
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2–
4).
Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (
2–
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2–
4).
Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (
2–
4).</description><subject>Biological and medical sciences</subject><subject>Cell Proliferation</subject><subject>Enzyme Inhibitors - chemical synthesis</subject><subject>Enzyme Inhibitors - chemistry</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Medical sciences</subject><subject>Pharmacology. 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During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (
2–
4).
Forodesine HCl is being investigated as a potential therapeutic target for the control of T-cell proliferation. During the filing process for a New Drug Application (NDA) it became evident that there was a need to synthesize some stereo-isomers of forodesine HCl. Herein we present the synthesis of these three novel compounds (
2–
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| fulltext | fulltext |
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| ispartof | Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (10), p.2627-2629 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Cell Proliferation Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Immunomodulators Medical sciences Pharmacology. Drug treatments PNP inhibitor Purine Nucleosides - chemical synthesis Purine Nucleosides - chemistry Purine Nucleosides - pharmacology Purine-Nucleoside Phosphorylase - antagonists & inhibitors Purine-Nucleoside Phosphorylase - metabolism Pyrimidinones - chemical synthesis Pyrimidinones - chemistry Pyrimidinones - pharmacology T-cell proliferation T-Lymphocytes - immunology T-Lymphocytes - metabolism |
| title | Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor—Part II |
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